MrgX2 antagonists

1. A compound according to Formula (I)

or a pharmaceutically acceptable salt thereof,

wherein:

W is N or CH;

each X 1 is independently N or CR 10 ;

each X 2 is independently N or CR 11 ;

Y 1 is N or CR 12 ;

Y 2 is N CR 12 ;

Z is

n is 0 or 1;

R 1 is hydrogen, halogen, (C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-NH 2 , -(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, -(C 1 -C 6 )alkyl-aryl, 5- or 6-membered heteroaryl(C 1 -C 4 )alkyl-, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, -(C 2 -C 6 )alkenyl-(C 3 -C 8 )cycloalkyl, —OH, (C 1 -C 4 )alkoxy, —O—(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, —O—(C 1 -C 6 )alkyl-aryl, —O—(C 1 -C 6 )alkyl-5-6 membered heteroaryl, —O—(C 2 -C 6 )alkenyl, —O—(C 3 -C 8 )cycloalkyl, —O-aryl, —O-heteroaryl, —C(O)-aryl, -CO 2 H, -CO 2 (C 1 -C 6 )alkyl, -CO 2 (C 3 -C 8 )cycloalkyl, -CO 2 C(C 1 -C 6 )alkyl, -O 2 C(C 3 -C 8 )cycloalkyl, -NH 2 , —NH(C 1 -C 6 )alkyl, -N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), aryl, or 5-6 membered heteroaryl, wherein any said (C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, -(C 1 -C 6 )alkyl-aryl, (C 1 -C 4 )alkoxy, -0-(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, —O—(C 3 -C 8 )cycloalkyl, —O-aryl, —O—5-6-membered heteroaryl, —C(O)-aryl, aryl, or 5-6 membered heteroaryl is optionally substituted one, two, or three times by R 14 ;

R 2 is hydrogen, halogen, (C 1 -C 6 )alkyl, or —OH, wherein any said (C 1 -C 6 )alkyl is optionally substituted one, two, or three times by halogen;

R 3 is hydrogen, halogen, (C 1 -C 6 )alkyl, or —OH, wherein any said (C 1 -C 6 )alkyl is optionally substituted one, two, or three times by halogen;

R 4 is hydrogen, halogen, or (C 1 -C 6 )alkyl;

R 5 is hydrogen, halogen, or (C 1 -C 6 )alkyl;

R 6 is hydrogen, halogen, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, (C 1 -C 4 )alkoxy, -(C 1 -C 6 )alkyl-OH, -(C 1 -C 6 )alkyl-O—(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-NH 2 , -(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-N-((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl)-OH, -(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl)-O—(C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-N-((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl)-OH, -(C 1 -C 6 )alkyl-N-((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl)-O—(C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-NH-(C 3 -C 8 )cycloalkyl, -(C 1 -C 6 )alkyl-NH-4- to 6-membered heterocycloalkyl, -(C 1 -C 6 )alkyl-4- to 6-membered heterocycloalkyl, -(C 1 -C 6 )alkyl-NHC(O)-((C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-SO 2 -(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-SO 2 —NH-(C 1 -C 6 )alkyl, —CN, —C(O)NH 2 , -C(O)NH(C 1 -C 6 )alkyl), —C(O)N(C 1 -C 6 )alkyl) (C 1 -C 6 )alkyl), —NH 2 , —NH(C 1 -C 6 )alkyl, -N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), -SO 2 ((C 1 -C 6 )alkyl), -SO 2 —NH((C 1 -C 6 )alkyl), or aryl, wherein any said (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, -(C 1 -C 6 )alkyl-OH, -(C 1 -C 6 )alkyl-NH 2 , -(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-NH-(C 3 -C 8 )cycloalkyl, -(C 1 -C 6 )alkyl-NH-4- to 6-membered heterocycloalkyl, or -(C 1 -C 6 )alkyl-4- to 6-membered heterocycloalkyl is optionally substituted one, two, or three times by halogen;

R 7 is hydrogen, (C 1 -C 6 )alkyl, or —OH;

R 8 is hydrogen, (C 1 -C 6 )alkyl, or (C 1 -C 4 )alkoxy;

R 9 is hydrogen, (C 1 -C 6 )alkyl, or (C 1 -C 4 )alkoxy;

each R 10 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, -(C 1 -C 6 )alkyl-NH 2 , -(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl), -(C 1 -C 6 )alkyl-N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), (C 2 -C 6 )alkenyl, —O—(C 1 -C 6 )alkyl, —NH 2 , —NH((C 1 -C 6 )alkyl), -N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), -NCH 2 , or —CHNH;

or R 1 and any R 10 taken together with the atoms to which they are attached, form a 5-, 6-, or 7-membered ring optionally containing one, two, or three heteroatoms independently selected from oxygen, nitrogen, and sulfur, wherein said ring is optionally substituted by one or two substituents independently selected from halogen, (C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, halo(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl;

each R 11 is independently hydrogen, halogen, (C 1 -C 6 )alkyl, or (C 2 -C 6 )alkenyl;

or any R 10 and any R 11 taken together with the atoms to which they are attached, form a 5-, 6-, or 7-membered ring optionally containing one, two, or three heteroatoms independently selected from oxygen, nitrogen, and sulfur; wherein said ring is optionally substituted by one or two substituents independently selected from halogen, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl;

R 12 is hydrogen, halogen, or (C 1 -C 6 )alkyl, wherein said (C 1 -C 6 )alkyl is optionally substituted one, two, or three times by halogen;

R 13 is hydrogen, (C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-SO 2 -(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-aryl, or -(C 1 -C 6 )alkyl-5-6-membered heteroaryl, wherein said (C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-SO 2 -(C 1 -C 6 )alkyl, -(C 1 -C 6 )alkyl-aryl, or -(C 1 -C 6 )alkyl-5-6-membered heteroaryl is optionally substituted one, two, or three times by halogen;

each R 14 is independently halogen, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, —CN, —(C 1 -C 6 )—OH, —(C 1 -C 6 )alkyl-NH 2 , —(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl), —(C 1 -C 6 )alkyl-N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), —OH, (C 1 -C 4 )alkoxy, -O—(C 3 -C 8 )cycloalkyl, -aryl, 5-6 membered heteroaryl, wherein (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, aryl, or 5-6 membered heteroaryl is further optionally substituted by one, two, or three substituents independently selected from halogen, (C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-OH, —(C 1 -C 6 )alkyl-O—(C 1 -C 6 )alkyl, or (C 1 -C 4 )alkoxy.

2. The compound or pharmaceutically acceptable salt thereof according to claim 1 wherein W is N.

3. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein Y 1 is CR 12 and R 12 is hydrogen or (C 1 -C 6 )alkyl optionally substituted one, two, or three times by halogen.

4. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein Y 2 is N.

5. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein Y 2 is CR 12 and R 12 is hydrogen.

6. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein Z is

and

R 13 is hydrogen, (C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-SO 2 —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-aryl, or -(C 1 -C 6 )alkyl-5-6-membered heteroaryl, wherein said (C 1 -C 6 )alkyl is optionally substituted one, two, or three times by halogen.

7. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein Z is

and

R 6 is hydrogen, (C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-OH, —(C 1 -C 6 )alkyl-NHC(O)—((C 1 -C 6 )alkyl), or —C(O)NH 2 , wherein any said (C 1 -C 6 )alkyl or —(C 1 -C 6 )alkyl-OH is optionally substituted one, two, or three times by halogen.

8. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein Z is

and

R 6 is hydrogen, —(C 1 -C 6 )alkyl-NH 2 , —(C 1 -C 6 )alkyl-4- to 6-membered heterocycloalkyl, -C(O)NH 2 , wherein any said —(C 1 -C 6 )alkyl-4- to 6-membered heterocycloalkyl is optionally substituted one, two, or three times by halogen.

9. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein n is 1.

10. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein

R 1 is halogen, (C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-NH 2 , —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, -(C 1 -C 6 )alkyl-aryl, 5- or 6-membered heteroaryl(C 1 -C 4 )alkyl-, (C 3 -C 8 )cycloalkyl, (C 2 -C 6 )alkenyl, —(C 2 -C 6 )alkenyl-(C 3 -C 8 )cycloalkyl, —OH, (C 1 -C 4 )alkoxy, —O—(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, —O—(C 1 -C 6 )alkyl-5-6 membered heteroaryl, —O—(C 3 -C 8 )cycloalkyl, —O-aryl, —O-heteroaryl, —C(O)-aryl, -CO 2 (C 3 -C 8 )cycloalkyl, —NH 2 , aryl, or 5-6 membered heteroaryl, wherein any said (C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, —(C 1 -C 6 )alkyl-aryl, (C 1 -C 4 )alkoxy, —O—(C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, —O—(C 3 -C 8 )cycloalkyl, —O-aryl, —O—5-6-membered heteroaryl, —C(O)-aryl, aryl, or 5-6 membered heteroaryl is optionally substituted one, two, or three times by R 14 ; and

each R 14 is independently halogen, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, —CN, —(C 1 -C 6 )—OH, —(C 1 -C 6 )alkyl-N((C 1 -C 6 )alkyl)((C 1 -C 6 )alkyl), —OH, (C 1 -C 4 )alkoxy, 5-6 membered heteroaryl, wherein (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, aryl, or 5-6 membered heteroaryl is further optionally substituted by one, two, or three substituents independently selected from halogen, (C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-OH, —(C 1 -C 6 )alkyl-O—(C 1 -C 6 )alkyl, or (C 1 -C 4 )alkoxy.

11. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein R 2 is hydrogen, halogen, or (C 1 -C 6 )alkyl; and/or R 3 is hydrogen, halogen, or (C 1 -C 6 )alkyl.

12. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein R 4 is hydrogen or halogen; and/or R 5 is hydrogen or halogen.

13. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein R 6 is hydrogen, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, —(C 1 -C 6 )alkyl-OH, (C 1 -C 6 )alkyl-NH 2 , —(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl), —(C 1 -C 6 )alkyl-N4C 1 -C 6 )alkyl*C 1 -C 6 )alkyl), —(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl)-OH, —(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl)-O—(C 1 -C 6 )alkyl), —(C 1 -C 6 )alkyl-NH-(C 3 -C 8 )cycloalkyl, —(C 1 -C 6 )alkyl-NH-4- to 6-membered heterocycloalkyl, —(C 1 -C 6 )alkyl-4- to 6-membered heterocycloalkyl, —(C 1 -C 6 )alkyl-NHC(O)—((C 1 -C 6 )alkyl), —(C 1 -C 6 )alkyl-SO 2 —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-SO 2 —NH 4 C 1 -C 6 )alkyl, —CN, —C(O)NH 2 , —NH 2 , -SO 2 ((C 1 -C 6 )alkyl), -SO 2 —NH((C 1 -C 6 )alkyl), or aryl, wherein any said (C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-OH, —(C 1 -C 6 )alkyl-NH 2 , —(C 1 -C 6 )alkyl-NH((C 1 -C 6 )alkyl), —(C 1 -C 6 )alkyl-NH-(C 3 -C 8 )cycloalkyl, —(C 1 -C 6 )alkyl-NH-4- to 6-membered heterocycloalkyl, or —(C 1 -C 6 )alkyl-4- to 6-membered heterocycloalkyl is optionally substituted one, two, or three times by halogen.

14. The compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein R 7 is hydrogen; and/or R 8 is (C 1 -C 6 )alkyl and R 9 is hydrogen.

15. The compound according to claim 1 which is:

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-phenoxypyridin-2-yl)propanamide;

(S)-N-(5-benzylpyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopentyloxy)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(54(E)-2-cyclopropylvinyl)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(6-benzylpyridazin-3-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(pyridin-4-ylmethyl)pyridin-2-yl)propanamide;

(S)-N-(5-cyclopentylpyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-cyclopropylpyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(m-tolyl)pyridin-2-yl)propanamide;

(S)-N-(2-cyclopropyloxazolo[4,5-b]pyridin-5-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-cyclobutylpyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(6-phenoxypyridazin-3-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(6-(o-tolyloxy)pyridazin-3-yl)propanamide;

N-(5-(2-cyclopropylethyl)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(benzyloxy)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-phenylpyridin-2-yl)propanamide;

N-(5-(cyclohexyloxy)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(6-cyclopropylquinolin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-isopropoxypyridin-2-yl)propanamide;

N-(5-(cyclohexylmethyl)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)-3-fluoropyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyrazin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-(cyclobutylmethoxy)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-(1-cyclopropylethoxy)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(6-cyclopropyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-(cyclopentylmethyl)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(isoquinolin-3-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyrimidin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)propanamide;

cyclobutyl 6-((S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamido)nicotinate;

(S)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(oxazol-2-ylmethoxy)pyridin-2-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(4,5-difluoropyridin-2-yl)propanamide;

N-(1-(cyclopropylmethyl)-1H-pyrazolo[3,4-c]pyridin-5-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-(cyclopropylmethyl)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-cyclohexylpyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(6-methoxypyridazin-3-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-methoxypyridin-2-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(pyridin-3-ylmethyl)pyridin-2-yl)propanamide;

cyclopentyl 6-((S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamido)nicotinate;

N-(5-(cyclopentylmethoxy)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-(cyclopropoxymethyl)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,2-difluoroethoxy)pyridin-2-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(thiophen-2-yl)pyridin-2-yl)propanamide;

N-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-c]pyridin-5-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(thiazol-2-ylmethyl)pyridin-2-yl)propanamide;

2((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(oxazol-2-ylmethyl)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(quinolin-2-yl)propanamide;

24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(1-methyl-1H-pyrazol-3-yl)pyridin-2-yl)propanamide;

24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(isoxazol-3-yl)pyridin-2-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(pyridin-2-ylmethyl)pyridin-2-yl)propanamide hydrochloride;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(pyridin-3-yloxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-phenoxypyrazin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(pyridin-2-yloxy)pyridin-2-yl)propanamide;

N-(6-(2-cyanophenoxy)pyridazin-3-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(6-(4-fluorophenoxy)pyridazin-3-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(pyridin-4-yloxy)pyridin-2-yl)propanamide;

(S)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(3-fluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((3,5-difluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(5-fluoropyridin-3-yl)oxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyrazin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(S) -N-(5-cyclopropylpyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(6-(cyclobutylmethoxy)pyridazin-3-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((2-oxo-1,2-dihydropyridin-3-yl)oxy)pyridin-2-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(spiro[3.3]heptan-2-yloxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(pyrimidin-4-yloxy)pyridin-2-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)-4-fluoropyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(6-cyclopropyl-1,8-naphthyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-cyclobutoxypyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N-(5-((Z)-2-cyclopropylvinyl)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-isopropylpyridin-2-yl)propanamide;

cyclopropyl 6-(2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamido)nicotinate;

(S)-N-(5-(cyclobutylmethyl)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyrazin-2-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(3-fluoro-5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)-3-fluoropyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(6-(neopentyloxy)pyridazin-3-yl)propanamide;

N-(5-((3-chloro-5-fluoropyridin-2-yl)oxy)pyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(3-fluoro-5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

N-(5-((3-cyano-5-fluoropyridin-2-yl)oxy)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(6-(spiro[3.3]heptan-2-yloxy)pyridazin-3-yl)propanamide;

N-(5-bromopyridin-2-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((6-methoxypyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4,6-trifluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4,5-trifluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2-((dimethylamino)methyl)-4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2-fluoro-4-(2-methylthiazol-4-yl)phenoxy)pyridin-2-yl)propanamide;

(S)-N-(6-cyclobutoxy pyridazin-3-yl)-24(S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(6-(cyclopentyloxy)pyridazin-3-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(difluoro(4-fluorophenyl)methyl)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((R)-4,4-difluoro-3-(5-oxo-4-(2,2,2-trifluoroethyl)-4, 5-dihydropyrazin-2-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-24(R)-3-(6-amino-5-oxo-4,5-dihydropyrazin-2-yl)-4,4-difluoropiperidin-1-yl)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)propanamide;

(S)-2-((R)-3-(6-amino-5-oxo-4,5-dihydropyrazin-2-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)propanamide;

(S)-24(R)-3-(6-amino-5-oxo-4,5-dihydropyrazin-2-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-2-((R)-3-(6-amino-5-oxo-4,5-dihydropyrazin-2-yl)-4,4-difluoropiperidin-1-yl)-N-(5-chloropyridin-2-yl)propanamide;

(S)-2-((R)-3-(6-amino-5-oxo-4,5-dihydropyrazin-2-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

4-((S)-1-((S)-1-((6-(cyclopropylmethoxy)pyridazin-3-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-(4,4-difluoro-1-(1-oxo-1-((5-phenoxypyridin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(cyclopropylmethoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-chloropyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-((5-fluoropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-((5-(4-fluorophenoxy)pyri din-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

44(S)-4,4-difluoro-1-((S)-(1-((5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-(1-((5-((3,5-difluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(2,4-difluorophenoxy)pyri din-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-((5-(4-fluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-oxo-1-((5-(2,4,6-trifluorophenoxy)pyrazin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-oxo-1-((5-(2,4,5-trifluorophenoxy)pyrazin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(2,6-difluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-oxo-1-((5-(2,3,4-trifluorophenoxy)pyrazin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-oxo-1-((5-(2,4,6-trifluorophenoxy)pyridin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-oxo-1-((5-(2,4,5-trifluorophenoxy)pyridin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-((5-((3-fluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-oxo-1-((5-(pyridin-2-yloxy)pyridin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(difluoro(4-fluorophenyl)methyl)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-145-(4-fluorobenzoyl)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

443S)-4,4-difluoro-1-(145-(4-fluorophenyl)(hydroxy)methyl)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(2,6-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-oxo-1-((5-(2,3,4-trifluorophenoxy)pyridin-2-yl)amino)propan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(2,4-difluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

(S)-N- (5-(cyclopropylmethoxy)pyridin-2-yl)-24(R)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazin-2-yl)piperidin-1-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((R)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazin-2-yl)piperidin-1-yl)propanamide;

(S)-2-((R)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazin-2-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((R)-4,4-difluoro-3-(5-oxo-4,5-dihydropyrazin-2-yl)piperidin-1-yl)propanamide;

(S)-N- (5-cyclopropylpyridin-2-yl)-2-((R)-4,4-difluoro-3-(5-oxo-4, 5-dihydropyrazin-2-yl)piperidin-1-yl)propanamide;

(S)-24(S)-3-(5-amino-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)propanamide;

2-(3-(5-amino-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-phenoxypyridin-2-yl)propanamide;

(S)-24(S)-3-(5-amino-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)propanamide;

(S)-24(S)-3-(5-amino-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-chloropyridin-2-yl)propanamide;

(S)-24(S)-3-(5-amino-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-2-((R)-3-(5-amino-6-oxo-1,6-dihydropyridazin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-2-((R)-3-(5-amino-6-oxo-1,6-dihydropyridazin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)propanamide;

(S)-N- (5-(cyclopropylmethoxy)pyridin-2-yl)-2-((R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridazin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridazin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-cyclopropylpyridin-2-yl)-24(R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridazin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridazin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N- (5-(cyclopropylmethoxy)pyridin-2-yl)-24(S)-4,4-difluoro-3-(1-methyl -6-oxo-1, 6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-5-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N - (5-(cyclopropylmethoxy)pyridin-2-yl)-2-((S)-4,4-difluoro-3-(5-(2-hydroxypropan-2-yl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-(4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-chloropyridin-2-yl)-2-(4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-24(S)-(4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-24(S)-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-2-((S)-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-2-((3S,4R)-(4-fluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-2-((3S,4S)-(4-fluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((3S,4R)-4-fluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-243S,4S)-4-fluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N-(5-fluoropyridin-2-yl)-2-((3S,5R)-3-methyl-5-(6-oxo-1,6-dihydropyridazin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-24(S)-4,4-difluoro-3-methyl-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

N-(5-(cyclopropylmethoxy)pyridin-2-yl)-2-(3,3-difluoro-4-(6-oxo-1,6-dihydropyridin-3-yl)pyrrolidin-1-yl)propanamide;

2-(3,3-difluoro-4-(6-oxo-1,6-dihydropyridin-3-yl)pyrrolidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((R)-(3-(5-oxo-4,5-dihydropyrazin-2-yl)piperidin-1-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((S)-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-3-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-chloropyridin-2-yl)propanamide;

(S)-N- (5-(cyclopropylmethoxy)pyridin-2-yl)-24(S)-3-(6-oxo-4-(trifluoromethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

((S)-2-((S)-3-(5-amino-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-chloropyridin-2-yl)propanamide;

(S)-N- (5-(cyclopropylmethoxy)pyridin-2-yl)-2-((R)-3-hydroxy-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((3S,5S)-(3-methyl-5-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((3R,5S)-(3-methyl-5-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((R)-3-(6-amino-5-oxo-4,5-dihydropyrazin-2-yl)piperidin-1-yl)-N-(5-chloropyridin-2-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-chloropyridin-2-yl)propanamide;

(S)-N- (5-chloropyridin-2-yl)-2-((S)-3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N- (5-chloropyridin-2-yl)-2-((S)-3-(5-(hydroxymethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N- (5-chloropyridin-2-yl)-2-((S)-3-(6-oxo-5-phenyl-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((S)-3-(5-cyclopropyl-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

4-((S)-1-((S)-1-((5-chloropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(2,4-difluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-2-(4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-2-methylpropanamide;

(S)-N-(5-chloropyridin-2-yl)-2-((S)-3-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(cyclopropylmethoxy)pyridin-2-yl)-2-((R)-3-(6-oxo-1,6-dihydropyridazin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-chloropyridin-2-yl)-24(R)-3-(6-oxo-1,6-dihydropyridazin-3-yl)piperidin-1-yl)propanamide;

(2S)-2-(3-(5-amino-6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(2S)-2-(3-(1-ethyl-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((S)-(3-(1-ethyl-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)propanamide;

(2S)-2-(4,4-difluoro-3-(1-(2-(methylsulfonyl)ethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(2 S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-(4,4-difluoro-3-(1-(2-(methylsulfonyl)ethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-(4,4-difluoro-3-(1-(2-(methylsulfonyl)ethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-24(S)-(3-(1-(2,2-difluoroethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(2S)-2-(4,4-difluoro-3-(1-isopropyl-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(5)-24(S)-(3-(1-benzyl-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(6-oxo-1-(pyridin-2-ylmethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(6-oxo-1-(pyridin-4-ylmethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(1-(oxazol-2-ylmethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(2S)-2-(4,4-difluoro-3-(5-(hydroxymethyl)-6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(2S)-2-(4,4-difluoro-3-(5-methyl-6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

2-(3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-phenoxypyridin-2-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyrazin-2-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-phenoxypyrazin-2-yl)propanamide;

(S)-24(S)-3-(5-(aminomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-54(S)-2,2,2-trifluoro-1-hydroxyethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-24(S)-4,4-difluoro-3-(6-oxo-5-((S)-2,2,2-trifluoro-1-hydroxyethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((S)-4,4-difluoro-3-(6-oxo-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(2S)-2-(4,4-difluoro-3-(6-oxo-5-(2,2,2-trifluoro-1-hydroxyethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(2S)-2-(4,4-difluoro-3-(6-oxo-5-(2,2,2-trifluoro-1-hydroxyethyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(5-((methylsulfonyl)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-((methylsulfonyl)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-((methylsulfonyl)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyrazin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-((methylsulfonyl)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

4-(4,4-difluoro-14(S)-1-(5-fluoropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-methylpyridine 1-oxide;

44(R)-4,4-difluoro-1-((R)-1-((5-(4-fluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-methylpyridine 1-oxide;

4-((S)-4,4-difluoro-1-((S)-1-((5-(4-fluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-methylpyridine 1-oxide;

4-((S)-4,4-difluoro-14(S)-1-(5-fluoropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-(2,2,2-trifluoroethyl)pyridine 1-oxide;

4-((S)-14(S)-146-(cyclopropylmethoxy)pyridazin-3-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)-2-(2,2,2-trifluoroethyl)pyridine 1-oxide;

(2S)-2-(3-(5-bromo-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)propanamide;

(2S)-2-(3-(5-(1-aminoethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)propanamide;

(2S)-2-(3-(5-cyano-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)propanamide;

(2S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-(4,4-difluoro-3-(pyridin-4-yl)piperidin-1-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((S)-4,4-difluoro-3-(5-(morpholinomethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

2-(4,4-difluoro-3-(5-(morpholinomethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-(morpholinomethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-(morpholinomethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((3,5-difluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-(morpholinomethyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyrazin-2-yl)propanamide;

2-(3-(5-((dimethylamino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-2-((S)-3-(5-((dimethylamino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)propanamide;

(2S)-2-(3-(5-(1-amino-2,2,2-trifluoroethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(S)-2-((S)-3-(5-((S)-1-amino-2,2,2-trifluoroethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-(S)-3-(5-((R)-1-amino-2,2,2-trifluoroethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-3-(5-((S)-1-amino-2,2,2-trifluoroethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-24(S)-3-(5-((R)-1-amino-2,2,2-trifluoroethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(5-((methylamino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(5-(((2-hydroxyethyl)amino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(5-(((2-methoxyethyl)amino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-N - (5-(2,4-difluorophenoxy)pyridin-2-yl)-2-((S)-3-(5,4,4-difluoropiperidin-1-yl)methyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)propanamide;

(S)-24(S)-3-(5-4(3,3-difluorocyclobutyl)amino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-54(2,2,2-trifluoroethyl)amino)methyl)-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(5-((methylamino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

S)-2-((S)-4,4-difluoro-3-(5-((methylamino)methyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyrazin-2-yl)propanamide;

(S)-24(S)-3-(5-(acetamidomethyl)-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(S)-N-(5-(4-fluorophenoxy)pyridin-2-yl)-24(S)-3-(5-(methylsulfonyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide (R)-N -(5-(4-fluorophenoxy)pyridin-2-yl)-24(R)-3-(5-(methylsulfonyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-N-(5-(4-fluorophenoxy)pyridin-2-yl)-2-((S)-3-(5-(N-methylsulfamoyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(R)-N -(5-(4-fluorophenoxy)pyridin-2-yl)-2-((R)-3-(5-(N-methylsulfamoyl)-6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)propanamide;

(S)-2-((S)-3,3-difluoro-5-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

(R)-24(R)-3,3-difluoro-5-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

2-(3-(5-cyano-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-fluoropyridin-2-yl)propanamide;

2-(3-(5-cyano-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyrazin-2-yl)propanamide;

(S)-2-((S)-3-(5-cyano-6-oxo-1,6-dihydropyridin-3-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

5-((S)-4,4-difluoro-1-((S)-1-(5-(4-fluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide;

5-(4,4-difluoro-1-(1-(5-fluoropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide;

4-((S)-4,4-difluoro-1-((S)-145-(4-fluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-(hydroxymethyl)pyridine 1-oxide;

4-((S)-1-((S)-1-((5-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)-2-(hydroxymethyl)pyridine 1-oxide;

4-(4,4-difluoro-1-(1-((5-fluoropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridine 1-oxide;

4-(4,4-difluoro-1-(1-((5-(4-fluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)-2-(2,2,2-trifluoro-1-hydroxyethyl)pyridine 1-oxide;

2-carbamoyl-4-((S)-1-((S)-1-((5-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

2-carbamoyl-44(S)-4,4-difluoro-1-((S)-1-((5-fluoropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

2-carbamoyl-4-(1-(1-((5-(2,4-difluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

4-(1-((S)-1-((5-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)picolinamide;

2-(acetamidomethyl)-4-(1-(1-((5-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide;

2-(acetamidomethyl)-4-(4,4-difluoro-1-(1-((5-fluoropyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

2-(3-(2-(aminomethyl)pyridin-4-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(2S)-2-(4,4-difluoro-3-(5-(2,2,2-trifluoro-1-hydroxyethyl)pyri din-3-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

3-(1-(1-45-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)-5-(2,2,2-trifluoro-1-hydroxyethyl)pyridine 1-oxide;

2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-((6-oxo-1,6-dihydropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(3,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluoro-2-methoxyphenoxy)pyridin-2-yl)propanamide;

(2S)-2-(3-(2-((3,3-difluoroazetidin-1-yl)methyl)pyridin-4-yl)-4,4-difluoropiperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluoro-2-(hydroxymethyl)phenoxy)pyridin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(4-fluoro-2-(hydroxymethyl)phenoxy)pyrazin-2-yl)propanamide;

4-((S)-4,4-difluoro-1-((S)-1-(5-(4-fluoro-2-(hydroxymethyl)phenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

4-((3S)-4,4-difluoro-1-(1-45-(4-fluoro-2-(hydroxymethyl)phenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)piperidin-3-yl)pyridine 1-oxide;

(R)-N -(5-(cyclopropylmethoxy)pyridin-2-yl)-241S,3R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)propanamide;

(R)-N-(6-(cyclopropylmethoxy)pyridazin-3-yl)-24/S,3R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)propanamide;

(R)-2-((1S,3R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)-N-(5-fluoropyridin-2-yl)propanamide;

2-(4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)-N-(5-(4-fluorophenoxy)pyridin-2-yl)propanamide;

(R)-2-((1S,3R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)-N-(5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(R)-2-((1S,3R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)propanamide;

(R)-2-((1S,3R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)-N-(5-((3,5-difluoropyridin-2-yl)oxy)pyridin-2-yl)propanamide;

(R)-N-(5-(2,4-difluorophenoxy)pyridin-2-yl)-241S,3R)-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)propanamide;

(R)-N-(5((5fluoropyridin-2yl)oxy)pyridin-2-yl)-241S,3R)-3-(6-oxo-1,6-dihydropyridin-3yl)cyclohexyl)propanamide;

N-(5-(4-fluorophenoxy)pyrazin-2-yl)-2-((3R)-3-(6-oxo-1,6dihydropyridin-3-yl)cyclohexyl)propanamide;

(R)-N -(5-(3,5-difluoropyridin-2-yl)oxy)pyridin-2-yl)-2-41S,3R)-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)propanamide;

(R)-N -(5-(2,4-difluorophenoxy)pyrazin-2-yl)-2-41S,3R)-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)propanamide;

4-(1R,3S)-3-(R)-1((5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)cyclohexyl)pyridine 1-oxide;

4-((1R,3S)-3-((R)-1-((5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)cyclohexyl)pyridine 1-oxide;

4-(1R,35)-3-((R)-1-((5-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)cyclohexyl)pyridine 1-oxide;

4-(1R,3S)-3-((S)-1-45-((3,5-difluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)cyclohexyl)pyridine 1-oxide;

4-((1R,5S)-5-((R)-1-((5-(2,4-difluorophenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-2,2-difluorocyclohexyl)pyridine 1-oxide;

4-((1R,5S)-2,2-difluoro-5-((R)-1-((5-(4-fluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)cyclohexyl)pyridine 1-oxide;

4-((1R,5S)-5-((R)-1-((5-((3,5-difluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-2,2-difluorocyclohexyl)pyridine 1-oxide;

4-((1R,5S)-2,2-difluoro-5-((R)-1-(5-((5-fluoropyridin-2-yl)oxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)cyclohexyl)pyridine 1-oxide; and

4-((1R,5S)-5-((R)-1-((5-(2,4-difluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)-2,2-difluorocyclohexyl)pyridine 1-oxide;

(R)-2-((1S,3R)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)cyclohexyl)-N-(5-(2,4-difluorophenoxy)pyrazin-2-yl)propenamide;

(S)-2-((S)-4,4-difluoro-3-(pyridin-4-yl)piperidin-1-yl)-N-(5-(2,4-difluorophenoxy)pyrazin-2-yl)propanamide;

4-((S)-1-((S)-1-45-(2,4-difluoro-6-(hydroxymethyl)phenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide 4-((S)-1-((S)-1-((5-(2,4-difluoro-6-(hydroxymethyl)phenoxy)pyridin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide (S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluoro-6-(hydroxymethyl)phenoxy)pyrazin-2-yl)propanamide;

(S)-2-((S)-4,4-difluoro-3-(6-oxo-1,6-dihydropyridin-3-yl)piperidin-1-yl)-N-(5-(2,4-difluoro-6-(hydroxymethyl)phenoxy)pyridin-2-yl)propanamide;

or pharmaceutically acceptable salts thereof.

16. The compound according to claim 1 which is 4-((S)-1-((S)-1-((5-(2,4-difluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide as represented by the below formula

or a pharmaceutically acceptable salt thereof.

17. The compound according to claim 16 , wherein the compound is a hydrochloride salt of 4-((S)-14(S)-1-45-(2,4-difluorophenoxy)pyrazin-2-yl)amino)-1-oxopropan-2-yl)-4,4-difluoropiperidin-3-yl)pyridine 1-oxide.

18. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt thereof according to claim 1 and a pharmaceutically acceptable excipient.

19. A method of treating an MrgX2-mediated disease or disorder in a human in need thereof comprising administering to the human a therapeutically effective amount of the compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the MrgX2-mediated disease or disorder is selected from the group consisting of chronic spontaneous urticaria, cold urticaria, atopic dermatitis, ulcerative colitis, inflammatory pain, asthma, chronic inducible urticaria, pseudo anaphylaxis, and contact urticaria.

20. The method according to claim 19 , wherein the MrgX2-mediated disease or disorder is chronic spontaneous urticaria.