Crystalline forms of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate
This invention relates to a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, and to pharmaceutical compositions thereof, to intermediates and methods for the production and isolation of such crystalline forms and compositions, and to methods of using such crystalline forms and compositions in the treatment of abnormal cell growth in mammals, especially humans.
1. A crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea imidazole complex (1:1), having the structure:
2. A process for preparing a crystalline form of 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate, having the structure:
and having a powder X-ray diffraction pattern comprising peaks at 2θ values of: 11.6, 12.1 and 19.6 °2θ±0.2 °2θ, said process comprising treating 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea imidazole complex (1:1) with maleic acid.
3. The process of claim 2 , wherein the reaction is conducted in a solvent, which solvent is isopropanol.
4. The process of claim 2 , wherein the maleic acid is added as a solution in isopropanol.
5. The crystalline form of claim 1 , having a powder X-ray diffraction pattern comprising peaks at 2⊖ values essentially the same as shown in FIG. 4 .
6. The crystalline form of claim 1 , having a powder X-ray diffraction pattern consisting of peaks at 2⊖ values essentially the same as shown in FIG. 4 .
7. The crystalline form of claim 1 , having a powder X-ray diffraction pattern consisting essentially of peaks at 2⊖ values essentially the same as shown in FIG. 4 .