IP Library › Granted Patent US 11,673,881

Granted Patent B2

US 11,673,881 · App. 17/495,281 · Granted Jun 13, 2023

Isoquinolin-3-yl carboxamides and preparation and use thereof

Inventors: Sunil Kumar KC (San Diego, CA); Gopi Kumar Mittapalli (San Diego, CA); Brian Joseph Hofilena (San Diego, CA); Joseph Timothy Marakovits (Encinitas, CA); Chandramouli Chiruta (San Diego, CA); Chi Ching Mak (San Diego, CA); Jianguo Cao (San Diego, CA)

Assignee: BioSplice Therapeutics, Inc.

C07D401/14 C07D401/04 C07D405/14 C07D413/14 C07D417/14 C07D455/02 C07D487/04 C07D487/08 C07D491/08

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Quick Facts

Patent No.: US 11,673,881
App. No.: 17/495,281
Granted: Jun 13, 2023
Kind: B2

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Abstract

Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an isoquinoline compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, inflammation, auto-immune diseases and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

Claims (1377)

1. A method of treating diabetes in a patient, the method comprising administering to the patient a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof:

wherein:

R 1 , R 2 , R 4 , and R 5 are independently selected from the group consisting of H, halide, unsubstituted —(C 1-3 haloalkyl), and unsubstituted —(C 1-3 alkyl);

R 3 is a 5-membered heteroaryl optionally substituted with 1-4 R 45 ;

with the proviso that R 3 is not

R 6 is selected from the group consisting of —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 36 , —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 37 , —(C 1-4 alkylene)N(R 46 )(R 47 ), —N(R 48 )(R 49 ), —CF(C 1-9 alkyl) 2 , —(C 1-4 alkylene) p O(C 3-9 alkyl), and —(C 2-9 alkynyl) optionally substituted with one or more halides; wherein each alkyl of —CF(C 1-9 alkyl) 2 is, independently, optionally substituted with one or more halides; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

with the proviso that R 6 is not unsubstituted —(CH 2 )tetrahydropyranyl;

each R 36 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 43 , —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 , —C(═O)(R 50 ), —(C 1-4 alkylene)C(═O)OR 51 , —(C 1-4 alkylene)aryl optionally substituted with one or more halides, —(C 1-4 alkylene) p heteroaryl optionally substituted with one or more halides, and —SO 2 (R 52 ); wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, two R 36 attached to the same carbon atom can together represent ═O to form a carbonyl group;

each R 37 is independently selected from the group consisting of halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene) p OR 42 , —N(R 53 ) 2 , —C(═O)(R 50 ), —C(═O)OR 51 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 43 , and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

each R 38 independently is selected from the group consisting of halide, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), —CN, and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

each R 39 is independently selected from the group consisting of halide, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), —CN, and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

each R 40 is independently selected from the group consisting of halide, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), —CN, and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

each R 41 is independently selected from the group consisting of halide, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), and —CN;

each R 42 is independently selected from the group consisting of H, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

each R 43 is independently selected from the group consisting of halide, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), —CN, and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

each R 44 is independently selected from the group consisting of halide, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), and —CN;

each R 45 is independently selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, two adjacent R 45 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R 46 is attached to the nitrogen and is selected from the group consisting of H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

R 47 is attached to the nitrogen and is selected from the group consisting of unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

R 48 is attached to the nitrogen and selected from the group consisting of H, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), and unsubstituted —(C 1-5 haloalkyl);

R 49 is attached to the nitrogen and is selected from the group consisting of —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

R 50 is selected from the group consisting of H, unsubstituted —(C 3-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), —(C 1-4 alkylene) p aryl optionally substituted with one or more halides or unsubstituted —(C 1-5 alkyl), —(C 1-4 alkylene) p heteroaryl optionally substituted with one or more halides or unsubstituted —(C 1-5 alkyl), and —(C 1-4 alkylene) p heterocyclyl optionally substituted with one or more halides or one or more unsubstituted —(C 1-5 alkyl); wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

R 51 is selected from the group consisting of H, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), —(C 1-4 alkylene) p aryl optionally substituted with one or more halides or unsubstituted —(C 1-5 alkyl), —(C 1-4 alkylene) p heteroaryl optionally substituted with one or more halides or unsubstituted —(C 1-5 alkyl), and —(C 1-4 alkylene) p heterocyclyl optionally substituted with one or more halides or one or more unsubstituted —(C 1-5 alkyl); wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

R 52 is selected from the group consisting of unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), —(C 1-4 alkylene) p aryl optionally substituted with one or more halides or unsubstituted —(C 1-5 alkyl), —(C 1-4 alkylene) p heteroaryl optionally substituted with one or more halides or unsubstituted —(C 1-5 alkyl), and —(C 1-4 alkylene) p heterocyclyl optionally substituted with one or more halides or one or more unsubstituted —(C 1-5 alkyl); wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

each R 53 is independently selected from the group consisting of H, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), and unsubstituted —(C 2-5 alkynyl);

each p is independently 0 or 1;

with the proviso that Formula I is not a structure selected from the group consisting of:

and

wherein each heterocyclyl is independently a nonaromatic cyclic ring system comprising at least one heteroatom in the ring system backbone.

2. The method of claim 1 , wherein R 1 , R 2 , R 4 , and R 5 are H.

3. The method of claim 2 , wherein R 3 is a pyrazolyl optionally substituted with 1-4 R 45 .

4. The method of claim 3 , wherein R 3 is a pyrazolyl substituted with one —(C 1-3 alkyl).

5. The method of claim 2 , wherein R 3 is an imidazolyl optionally substituted with 1-4 R 45 .

6. The method of claim 5 , wherein R 3 is a imidazolyl substituted with one —(C 1-3 alkyl).

7. The method of claim 2 , wherein R 3 is a triazolyl optionally substituted with 1-4 R 45 .

8. The method of claim 7 , wherein R 3 is a triazolyl substituted with one —(C 1-3 alkyl).

9. A method of treating diabetes in a patient, the method comprising administering to the patient a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof:

wherein:

R 1 , R 2 , R 4 , and R 5 are independently selected from the group consisting of H, halide, unsubstituted —(C 1-3 haloalkyl), and unsubstituted —(C 1-3 alkyl);

R 3 is selected from the group consisting of:

wherein each of R 7 -R 35 is, independently, a substituent as defined anywhere herein or a single bond connecting R 3 to the isoquinoline ring; wherein only one of R 7 -R 10 (when present) is a bond, only one of R 11 -R 14 (when present) is a bond, only one of R 15 -R 17 (when present) is a bond, only one of R 18 -R 20 (when present) is a bond, only one of R 21 -R 23 (when present) is a bond, only one of R 24 -R 26 (when present) is a bond, only one of R 27 -R 29 (when present) is a bond, only one of R 30 -R 31 (when present) is a bond, only one of R 32 -R 33 (when present) is a bond, and only one of R 34 -R 35 (when present) is a bond; wherein any one of the nitrogen atoms attached to R 7 , R 11 , R 15 , R 18 , or R 21 can serve as the point of attachment of R 3 to the isoquinoline ring; wherein any one of the carbon atoms attached to R 8 , R 9 , R 10 , R 12 , R 13 , R 14 , R 16 , R 17 , R 19 , R 20 , R 22 , R 23 , R 24 , R 25 , R 26 , R 27 , R 28 , R 29 , R 30 , R 31 , R 32 , R 33 , R 34 , or R 35 can serve as the point of attachment of R 3 to the isoquinoline ring; so that:

when the nitrogen atom to which R 7 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 7 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 8 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 8 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 9 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 9 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 10 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 10 is a single bond connecting R 3 to the isoquinoline ring;

when the nitrogen atom to which R 1 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 11 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 12 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 12 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 13 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 13 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 14 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 14 is a single bond connecting R 3 to the isoquinoline ring;

when the nitrogen atom to which R 15 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 15 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 16 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 16 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 17 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 17 is a single bond connecting R 3 to the isoquinoline ring;

when the nitrogen atom to which R 18 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 18 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 19 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 19 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 20 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 20 is a single bond connecting R 3 to the isoquinoline ring;

when the nitrogen atom to which R 21 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 21 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 22 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 22 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 23 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 23 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 24 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 24 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 25 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 25 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 26 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 26 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 27 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 27 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 28 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 28 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 29 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 29 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 30 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 30 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 31 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 31 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 32 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 32 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 33 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 33 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 34 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 34 is a single bond connecting R 3 to the isoquinoline ring;

when the carbon atom to which R 35 is attached serves as the point of attachment of R 3 to the isoquinoline ring, then R 35 is a single bond connecting R 3 to the isoquinoline ring;

with the proviso that R 6 is not unsubstituted —(CH 2 )tetrahydropyranyl;

R 7 is selected from the group consisting of a single bond, H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene)OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

R 8 , R 9 , and R 10 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, one of R 7 and R 8 , R 8 and R 9 , or R 9 and R 10 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R″ is selected from the group consisting of a single bond, H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene)OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

R 12 , R 13 , and R 14 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, one of R 11 and R 12 , R 12 and R 13 , or R 14 and R 11 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R 15 is selected from the group consisting of a single bond, H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene)OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

R 16 and R 17 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, one of R 15 and R 16 or R 16 and R 17 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R 18 is selected from the group consisting of a single bond, H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene)OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

R 19 and R 20 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, one of R 18 and R 19 or R 18 and R 20 are taken together to form a heterocyclyl optionally substituted with 1-10 R 40 ;

R 21 is selected from the group consisting of a single bond, H, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —(C 1-4 alkylene)OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein —(C 1-4 alkylene) is, optionally substituted with one or more substituents as defined anywhere herein;

R 22 and R 23 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, R 22 and R 23 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R 24 , R 25 , and R 26 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

with the proviso that when R 25 is a single bond connecting R 3 to the isoquinoline ring, R 24 and R 26 are not methyls;

alternatively, one of R 24 and R 25 or R 25 and R 26 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R 27 , R 28 , and R 29 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, R 27 and R 28 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R 30 and R 31 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, R 30 and R 31 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

R 32 and R 33 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

R 34 and R 35 are independently selected from the group consisting of a single bond, H, halide, unsubstituted —(C 1-9 alkyl), unsubstituted —(C 2-9 alkenyl), unsubstituted —(C 2-9 alkynyl), unsubstituted —(C 1-9 haloalkyl), —N(R 53 ) 2 , —(C 1-4 alkylene) p OR 42 , —(C 1-4 alkylene) p heterocyclyl optionally substituted with 1-10 R 38 , and -carbocyclyl optionally substituted with 1-12 R 39 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

alternatively, R 34 and R 35 are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R 40 and -carbocyclyl optionally substituted with 1-12 R 41 ;

alternatively, two R 36 attached to the same carbon atom can together represent ═O to form a carbonyl group;

each R 42 is independently selected from the group consisting of unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), unsubstituted —(C 2-5 alkynyl), unsubstituted —(C 1-5 haloalkyl), and —(C 1-4 alkylene) p carbocyclyl optionally substituted with 1-12 R 44 ; wherein each —(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein;

each R 53 is independently selected from the group consisting of H, unsubstituted —(C 1-5 alkyl), unsubstituted —(C 2-5 alkenyl), and unsubstituted —(C 2-5 alkynyl);

each X is O or S;

each p is independently 0 or 1;

with the proviso that Formula I is not a structure selected from the group consisting of:

and

wherein each heterocyclyl is independently a nonaromatic cyclic ring system comprising at least one heteroatom in the ring system backbone.

10. The method of claim 9 , wherein R 1 , R 2 , R 4 , and R 5 are H.

11. The method of claim 10 , wherein R 3 is selected from the group consisting of:

and X is O or S.

12. The method of claim 11 , wherein R 3 is selected from the group consisting of:

13. The method of claim 12 , wherein R 3 is selected from the group consisting of:

wherein R 7 , R 11 , R 14 , R 15 , R 18 , R 19 , R 28 , R 29 , and R 32 are independently selected from the group consisting of H and —(C 1-3 alkyl).

14. The method of claim 1 , wherein R 6 is a -heterocyclyl optionally substituted with 1-2 R 36 .

15. The method of claim 4 , wherein R 6 is a -heterocyclyl optionally substituted with 1-2 R 36 .

16. The method of claim 9 , wherein R 6 is a -heterocyclyl optionally substituted with 1-2 R 36 .

17. The method of claim 13 , wherein R 6 is a -heterocyclyl optionally substituted with 1-2 R 36 .

18. The method of claim 1 , wherein R 6 is a —CH 2 heterocyclyl optionally substituted with 1-2 R 36 .

19. The method of claim 4 , wherein R 6 is a —CH 2 heterocyclyl optionally substituted with 1-2 R 36 .

20. The method of claim 9 , wherein R 6 is a —CH 2 heterocyclyl optionally substituted with 1-2 R 36 .

21. The method of claim 13 , wherein R 6 is a —CH 2 heterocyclyl optionally substituted with 1-2 R 36 .

22. The method of claim 14 , wherein R 6 is a piperidinyl substituted with one —(C 1-5 alkyl).

23. The method of claim 15 , wherein R 6 is a piperidinyl substituted with one —(C 1-5 alkyl).

24. The method of claim 16 , wherein R 6 is a piperidinyl substituted with one —(C 1-5 alkyl).

25. The method of claim 17 , wherein R 6 is a piperidinyl substituted with one —(C 1-5 alkyl).

26. The method of claim 14 , wherein R 6 is a piperidinyl substituted with one —(C 1-3 haloalkyl).

27. The method of claim 15 , wherein R 6 is a piperidinyl substituted with one —(C 1-3 haloalkyl).

28. The method of claim 16 , wherein R 6 is a piperidinyl substituted with one —(C 1-3 haloalkyl).

29. The method of claim 17 , wherein R 6 is a piperidinyl substituted with one —(C 1-3 haloalkyl).

30. The method of claim 18 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-5 alkyl).

31. The method of claim 19 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-5 alkyl).

32. The method of claim 20 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-5 alkyl).

33. The method of claim 21 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-5 alkyl).

34. The method of claim 18 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-3 haloalkyl).

35. The method of claim 19 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-3 haloalkyl).

36. The method of claim 20 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-3 haloalkyl).

37. The method of claim 21 , wherein R 6 is a —CH 2 piperidinyl substituted with one —(C 1-3 haloalkyl).

38. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide [1];

N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexanecarboxamide [2];

4,4-Difluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [3];

trans-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [6];

cis-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [7];

trans-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [8];

cis-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [9];

trans-4-((3-Fluoroazetidin-1-yl)methyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [10];

cis-4-((3-Fluoroazetidin-1-yl)methyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [11];

trans-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-(morpholinomethyl)cyclohexane-1-carboxamide [12];

cis-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-(morpholinomethyl)cyclohexane-1-carboxamide [13];

trans-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [14];

cis-N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [15];

N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [16];

1-Methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [17];

1-Ethyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [18];

1-Isopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [19];

1-Cyclopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [20];

1-Isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [21];

N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-neopentylazetidine-3-carboxamide [22];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)azetidine carboxamide [23];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)azetidine carboxamide [24];

1-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [25];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)azetidine-3-carboxamide [26];

1-(2,2-difluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [27];

1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [28];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)azetidine-3-carboxamide [29];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)azetidine-3-carboxamide [30];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)azetidine-3-carboxamide [31];

1-(2-methoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [32];

1-(2-isopropoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [33];

3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [34];

3-fluoro-1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [35];

1-ethyl-3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [36];

3-fluoro-1-isopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [37];

1-cyclopropyl-3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [38];

3-fluoro-1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [39];

3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-neopentylazetidine-3-carboxamide [40];

3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)azetidine-3-carboxamide [41];

3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) azetidine-3-carboxamide [42];

3-fluoro-1-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [43];

1-(2,2-difluoroethyl)-3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [44];

3-fluoro-1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine carboxamide [45];

3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)azetidine-3-carboxamide [46];

3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)azetidine carboxamide [47];

3-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)azetidine-3-carboxamide [48];

3-fluoro-1-(2-methoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [49];

3-fluoro-1-(2-isopropoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [50];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [51];

1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [52];

1-ethyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [53];

1-isopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [54];

1-cyclopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [55];

1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [56];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-neopentylpyrrolidine-3-carboxamide [57];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)pyrrolidine-3-carboxamide [58];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)pyrrolidine-3-carboxamide [59];

1-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [60];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)pyrrolidine-3-carboxamide [61];

1-(2,2-difluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [62];

1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [63];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)pyrrolidine-3-carboxamide [64];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)pyrrolidine carboxamide [65];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)pyrrolidine-3-carboxamide [66];

1-(2-methoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [67];

1-(2-isopropoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [68];

(S)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [69];

(R)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [70];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [71];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [72];

1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [73];

1-ethyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [74];

1-isopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [75];

1-cyclopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [76];

1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [77];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [78];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)piperidine-4-carboxamide [79];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [80];

1-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [81];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [82];

1-(2,2-difluoropropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [83];

1-(2,2-difluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [84];

1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [85];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [86];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [87];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)piperidine-4-carboxamide [88];

1-(2-methoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [89];

1-(2-isopropoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [90];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [91];

4-fluoro-1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [92];

1-ethyl-4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [93];

4-fluoro-1-isopropyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [94];

1-cyclopropyl-4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [95];

4-fluoro-1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [96];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [97];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)piperidine-4-carboxamide [98];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [99];

4-fluoro-1-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [100];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [101];

1-(2,2-difluoropropyl)-4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [102];

1-(2,2-difluoroethyl)-4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [103];

4-fluoro-1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [104];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [105];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [106];

4-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)piperidine-4-carboxamide [107];

4-fluoro-1-(2-methoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [108];

4-fluoro-1-(2-isopropoxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [109];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [110];

(R)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [111];

(S)-1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [112];

(R)-1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [113];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [115];

2-(4-fluoropiperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [116];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [117];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [118];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide [119];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexanecarboxamide [120];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4,4-difluorocyclohexane-1-carboxamide [121];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-methoxycyclohexane-1-carboxamide [122];

cis-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-methoxycyclohexane-1-carboxamide [123];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [124];

cis-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [125];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [126];

cis-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [127];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-((3-fluoroazetidin-1-yl)methyl) cyclohexane-1-carboxamide [128];

cis-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-((3-fluoroazetidin-1-yl)methyl) cyclohexane-1-carboxamide [129];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-(morpholinomethyl)cyclohexane-1-carboxamide [130];

cis-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-(morpholinomethyl)cyclohexane-1-carboxamide [131];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [132];

cis-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [133];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)azetidine-3-carboxamide [134];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-methylazetidine-3-carboxamide [135];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-ethylazetidine-3-carboxamide [136];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isopropylazetidine-3-carboxamide [137];

1-cyclopropyl-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)azetidine-3-carboxamide [138];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isobutylazetidine-3-carboxamide [139];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-neopentylazetidine-3-carboxamide [140];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)azetidine-3-carboxamide [141];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) azetidine-3-carboxamide [142];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoroethyl)azetidine-3-carboxamide [143];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)azetidine-3-carboxamide [144];

1-(2,2-difluoroethyl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)azetidine-3-carboxamide [145];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoro-2-methylpropyl)azetidine-3-carboxamide [146];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)azetidine-3-carboxamide [147];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)azetidine-3-carboxamide [148];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)azetidine-3-carboxamide [149];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-methoxyethyl)azetidine-3-carboxamide [150];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-isopropoxyethyl)azetidine-3-carboxamide [151];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoroazetidine-3-carboxamide [152];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-methylazetidine-3-carboxamide [153];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-ethyl-3-fluoroazetidine-3-carboxamide [154];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-isopropylazetidine-3-carboxamide [155];

1-cyclopropyl-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoroazetidine-3-carboxamide [156];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-isobutylazetidine-3-carboxamide [157];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-neopentylazetidine-3-carboxamide [158];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-((1-methylcyclopropyl)methyl) azetidine-3-carboxamide [159];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-((1-(trifluoromethyl)cyclopropyl) methyl)azetidine-3-carboxamide [160];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-(2-fluoroethyl)azetidine-3-carboxamide [161];

1-(2,2-difluoroethyl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoroazetidine-3-carboxamide [162];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-(2-fluoro-2-methylpropyl)azetidine-3-carboxamide [163];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-(oxetan-3-yl)azetidine-3-carboxamide [164];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-((3-methyloxetan-3-yl)methyl) azetidine-3-carboxamide [165];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-(oxetan-2-ylmethyl)azetidine-3-carboxamide [166];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-(2-methoxyethyl)azetidine-3-carboxamide [167];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3-fluoro-1-(2-isopropoxyethyl)azetidine-3-carboxamide [168];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [169];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-methylpyrrolidine-3-carboxamide [170];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-ethylpyrrolidine-3-carboxamide [171];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isopropylpyrrolidine-3-carboxamide [172];

1-cyclopropyl-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [173];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isobutylpyrrolidine-3-carboxamide [174];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-neopentylpyrrolidine-3-carboxamide [175];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)pyrrolidine carboxamide [176];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) pyrrolidine-3-carboxamide [177];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoroethyl)pyrrolidine-3-carboxamide [178];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)pyrrolidine-3-carboxamide [179];

1-(2,2-difluoroethyl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [180];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoro-2-methylpropyl)pyrrolidine-3-carboxamide [181];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)pyrrolidine-3-carboxamide [182];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)pyrrolidine-3-carboxamide [183];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)pyrrolidine-3-carboxamide [184];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-methoxyethyl)pyrrolidine-3-carboxamide [185];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-isopropoxyethyl)pyrrolidine-3-carboxamide [186];

(R)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [187];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [188];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [189];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide [190];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-ethylpiperidine-4-carboxamide [191];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isopropylpiperidine-4-carboxamide [192];

1-cyclopropyl-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [193];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isobutylpiperidine-4-carboxamide [194];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [195];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((1-methylcyclopropyl)methyl)piperidine carboxamide [196];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [197];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoroethyl)piperidine-4-carboxamide [198];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine carboxamide [199];

1-(2,2-difluoropropyl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [200];

1-(2,2-difluoroethyl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [201];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoro-2-methylpropyl)piperidine-4-carboxamide [202];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [203];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [204];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxetan-2-ylmethyl)piperidine-4-carboxamide [205];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-methoxyethyl)piperidine-4-carboxamide [206];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-isopropoxyethyl)piperidine-4-carboxamide [207];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoropiperidine-4-carboxamide [208];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-methylpiperidine-4-carboxamide [209];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-ethyl-4-fluoropiperidine-4-carboxamide [210];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-isopropylpiperidine-4-carboxamide [211];

1-cyclopropyl-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoropiperidine-4-carboxamide [212];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [213];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-neopentylpiperidine-4-carboxamide [214];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-((1-methylcyclopropyl)methyl) piperidine-4-carboxamide [215];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-((1-(trifluoromethyl)cyclopropyl) methyl)piperidine-4-carboxamide [216];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-(2-fluoroethyl)piperidine-4-carboxamide [217];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [218];

1-(2,2-difluoropropyl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoropiperidine-4-carboxamide [219];

1-(2,2-difluoroethyl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoropiperidine-4-carboxamide [220];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-(2-fluoro-2-methylpropyl)piperidine-4-carboxamide [221];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-(oxetan-3-yl)piperidine-4-carboxamide [222];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-((3-methyloxetan-3-yl)methyl) piperidine-4-carboxamide [223];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-(oxetan-2-ylmethyl)piperidine-4-carboxamide [224];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-(2-methoxyethyl)piperidine-4-carboxamide [225];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-fluoro-1-(2-isopropoxyethyl)piperidine-4-carboxamide [226];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [227];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [228];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-fluoropiperidin-1-yl)acetamide [229];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [230];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide [231];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)cyclohexanecarboxamide [232];

4,4-difluoro-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [233];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)azetidine-3-carboxamide [234];

1-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)azetidine-3-carboxamide [235];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [236];

1-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [237];

1-(2-fluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)pyrrolidine-3-carboxamide [238];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)pyrrolidine-3-carboxamide [239];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [240];

1-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [241];

1-ethyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [242];

1-isopropyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [243];

1-cyclopropyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [244];

1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [245];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [246];

1-(2-fluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [247];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [248];

1-(2,2-difluoropropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [249];

1-(2,2-difluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [250];

1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [251];

4-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [252];

4-fluoro-1-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [253];

4-fluoro-1-(2-fluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [254];

4-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine carboxamide [255];

1-(2,2-difluoropropyl)-4-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine carboxamide [256];

1-(2,2-difluoroethyl)-4-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine carboxamide [257];

4-fluoro-1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)piperidine carboxamide [258];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [259];

2-(4-fluoropiperidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)acetamide [260];

N-(6-(1-methyl-1H-1,2,3-triazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [261];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [262];

4,4-difluoro-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [263];

1-methyl-N-(6-(1-methyl-1H-pyrazol-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide [264];

N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide [265];

N-(6-(7-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)cyclopropanecarboxamide [266];

3,3-difluoro-N-(6-(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)cyclobutane-1-carboxamide [267];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-3,3-difluorocyclobutane-1-carboxamide [268];

2,2,3,3-tetramethyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclopropane-1-carboxamide [269];

N-(6-(1-methyl-1H-pyrazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [270];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [271];

2-(4-isobutylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [272];

2-(3,3-dimethylazetidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [273];

(R)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [274];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [275];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [276];

2,2,3,3-tetramethyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclopropane-1-carboxamide [277];

N-(6-(4-methyl-4H-1,2,4-triazol-3-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [278];

N-(6-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine carboxamide [279];

4-fluoro-1-isobutyl-N-(6-(4-methyl-4H-1,2,4-triazol-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide [280];

4-fluoro-1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [281];

1-ethyl-4-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [282];

4,4-difluoro-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl) cyclohexane-1-carboxamide [283];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [284];

N-(6-(1-ethyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [285];

N-(6-(1-cyclopropyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [286];

2-(pyrrolidin-1-yl)-N-(6-(5-(trifluoromethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [287];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [288];

(R)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [289];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [290];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [291];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [292];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [293];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [294];

2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [295];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [296];

N-(6-(1-cyclopropyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [297];

N-(6-(5-(azetidin-1-ylmethyl)-1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4,4-difluorocyclohexane-1-carboxamide [298];

4,4-difluoro-N-(6-(1-methyl-5-(pyrrolidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [299];

4,4-difluoro-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane carboxamide [300];

7-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-7-azaspiro[3.5]nonane carboxamide [301];

2-(cyclobutyl(methyl)amino)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [302];

2-(diethylamino)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [303];

N-(6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine carboxamide [304];

N-(6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [305];

N-(6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [306];

N-(6-(3-methylisoxazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [307];

N-(6-(oxazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [308];

4-fluoro-1-isobutyl-N-(6-(5-methyl-1,3,4-oxadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [309];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [310];

(S)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [311];

2-fluoro-2-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)propanamide [312];

(R)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [313];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)propanamide [314];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl-2,2,5,5-d4)acetamide [315];

4-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperazine-1-carboxamide [316];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [317];

(R)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [318];

2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [319];

(R)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [320];

2-fluoro-2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)propanamide [321];

1-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [322];

3,3-difluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclobutane-1-carboxamide [323];

2-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [324];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane carboxamide [325];

2-(2-fluoroethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane carboxamide [326];

trans-4-(dimethylamino)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [327];

1-benzoyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [328];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [330];

1′-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-[1,4′-bipiperidine]-4-carboxamide [331];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [332];

trans-4-(hydroxymethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [333];

methyl 2-(4-((6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [334];

1-benzyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [335];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [336];

1-fluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropane-1-carboxamide [337];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-morpholinoacetamide [338];

trans-4-formyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [339];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-2-carboxamide [340];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [341];

(R)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [342];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylmorpholino)acetamide [343];

2-((2R,6S)-2,6-dimethylmorpholino)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [344];

2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [345];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [346];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [347];

(S)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-morpholinopropanamide [348];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(morpholin-2-yl)acetamide [349];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylmorpholin-2-yl)acetamide [350];

2-(4-ethylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [351];

2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [352];

2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [353];

2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [354];

(S)-2-(2,4-dimethylpiperazin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [355];

7-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-7-azaspiro[3.5]nonane-2-carboxamide [356];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [357];

1-(2-hydroxyethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [358];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [359];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [360];

2-(3,3-dimethylazetidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [361];

(R)—N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-oxotetrahydro-1H-pyrrolo[1,2-c]imidazole-2 (3H)-carboxamide [362];

(R)-1-methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [363];

N-(4-chloro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide [364];

trans-4-amino-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [365];

N-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [366];

N-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-isobutylpiperidine-4-carboxamide [367];

N-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-fluoroethyl)piperidine-4-carboxamide [368];

N-(7-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [369];

N-(7-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-isobutylpiperidine-4-carboxamide [370];

N-(7-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-fluoroethyl)piperidine-4-carboxamide [371];

N-(7-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [372];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-fluoro-2-methylpropanamide [373];

2-(diethylamino)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [374];

2-(cyclobutyl(methyl)amino)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [375];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-fluorocyclopropane-1-carboxamide [376];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-methyl-2-azaspiro[3.3]heptane-6-carboxamide [377];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2-fluoroethyl)-2-azaspiro[3.3]heptane carboxamide [378];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [379];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-7-methyl-7-azaspiro[3.5]nonane-2-carboxamide [380];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-fluorocyclohexane-1-carboxamide [381];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-(dimethylamino)cyclohexane-1-carboxamide [382];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-formylcyclohexane-1-carboxamide [383];

trans-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-(hydroxymethyl)cyclohexane-1-carboxamide [384];

(R)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [385];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [386];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-hydroxyethyl)piperidine-4-carboxamide [387];

methyl 2-(4-((6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [388];

(R)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoropropyl)piperidine-4-carboxamide [389];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-fluoropropyl)piperidine-4-carboxamide [390];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [391];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [392];

1-benzoyl-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [393];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1′-methyl-[1,4′-bipiperidine]-4-carboxamide [394];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [395];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [396];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [397];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [398];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isobutylpiperidine-3-carboxamide [399];

(R)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-isobutylpiperidine-3-carboxamide [400];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-methylpiperazine-1-carboxamide [401];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(3,3-dimethylazetidin-1-yl)acetamide [402];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [403];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(3-fluoropyrrolidin-1-yl)acetamide [404];

(R)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(3-fluoropyrrolidin-1-yl)acetamide [405];

(R)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [406];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [407];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [408];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [409];

2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [410];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [411];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [412];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)propanamide [413];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [414];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-ethylpiperazin-1-yl)acetamide [415];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-(2-fluoroethyl)piperazin-1-yl)acetamide [416];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2,4-dimethylpiperazin-1-yl)acetamide [417];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-isopropylpiperazin-1-yl)acetamide [418];

2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [419];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-morpholinoacetamide [420];

(R)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [421];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [422];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2-methylmorpholino)acetamide [423];

(S)—N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-morpholinopropanamide [424];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(morpholin-2-yl)acetamide [425];

N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-methylmorpholin-2-yl)acetamide [426];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [427];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [428];

2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [429];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(1,2-dimethyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [430];

2-(diethylamino)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [431];

2-(cyclobutyl(methyl)amino)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [432];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide [433];

1-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclopropane-1-carboxamide [434];

3,3-difluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclobutane-1-carboxamide [435];

2-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [436];

2-(2-fluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [437];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [438];

7-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-7-azaspiro[3.5]nonane-2-carboxamide [439];

1-fluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [440];

4,4-difluoro-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [441];

trans-4-methoxy-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [442];

trans-4-(dimethylamino)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [443];

trans-4-formyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [444];

trans-4-(hydroxymethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)cyclohexane carboxamide [445];

trans-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [446];

trans-44 (3-fluoroazetidin-1-yl)methyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl) cyclohexane-1-carboxamide [447];

trans-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)cyclohexane-1-carboxamide [448];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [449];

(R)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [450];

(R)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [451];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [452];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [453];

1-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [454];

4-fluoro-1-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [455];

1-(2-fluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [456];

4-fluoro-1-(2-fluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [457];

1-(2,2-difluoroethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [458];

1-(2-hydroxyethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [459];

1-(2-methoxyethyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [460];

methyl 2-(4-((6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [461];

1-isopropyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [462];

1-cyclopropyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [463];

(R)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [464];

(S)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [465];

1-(2,2-difluoropropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [466];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [467];

1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [468];

1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine carboxamide [469];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [470];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [471];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [472];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [473];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [474];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [475];

1-benzoyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [476];

1′-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-[1,4′-bipiperidine]-4-carboxamide [477];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [478];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [579];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [480];

(R)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [481];

1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [482];

(R)-1-isobutyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [483];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [484];

4-methyl-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperazine-1-carboxamide [485];

2-(3,3-dimethylazetidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [486];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [487];

(S)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [488];

(R)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [489];

(R)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [490];

(S)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [491];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [492];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [493];

2-(4-fluoropiperidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [494];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [495];

2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [496];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [497];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [498];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)propanamide [499]; and

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [500]; or a pharmaceutically acceptable salt thereof.

39. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

2-(4-ethylpiperazin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [501];

2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [502];

(S)-2-(2,4-dimethylpiperazin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [503];

2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [504];

2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [505];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-morpholinoacetamide [506];

(R)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [507];

(S)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [508];

(S)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(2-methylmorpholino)acetamide [509];

(S)—N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-morpholinopropanamide [510];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(morpholin-2-yl)acetamide [511];

N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)-2-(4-methylmorpholin-2-yl)acetamide [512];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [513];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin yl)acetamide [514];

2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [515];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)acetamide [516];

2-fluoro-2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)propanamide [517];

2-(diethylamino)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [518];

2-(cyclobutyl(methyl)amino)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [519];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide [520];

1-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclopropane-1-carboxamide [521];

3,3-difluoro-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclobutane-1-carboxamide [522];

2-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [523];

2-(2-fluoroethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [524];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [525];

7-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-7-azaspiro[3.5]nonane-2-carboxamide [526];

1-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [527];

trans-4-methoxy-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [528];

trans-4-(dimethylamino)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [529];

trans-4-formyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [530];

trans-4-(hydroxymethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [531];

trans-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [532];

trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [533];

trans-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)cyclohexane-1-carboxamide [534];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)azetidine-3-carboxamide [535];

(R)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [536];

(R)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [537];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [538];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [539];

1-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [540];

4-fluoro-1-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [541];

1-ethyl-4-fluoro-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [542];

1-(2-fluoroethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [543];

4-fluoro-1-(2-fluoroethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [544];

1-(2,2-difluoroethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [545];

1-(2-hydroxyethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [546];

1-(2-methoxyethyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [547];

methyl 2-(4-((6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [548];

1-isopropyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [549];

1-cyclopropyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [550];

(R)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [551];

(S)-1-(2-fluoropropyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [552];

1-(2,2-difluoropropyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [553];

1-isobutyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [554];

4-fluoro-1-isobutyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [555];

1-(2-fluoro-2-methylpropyl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine carboxamide [556];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [557];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [558];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine carboxamide [559];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [560];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [561];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [562];

1-benzoyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [563];

1′-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-[1,4′-bipiperidine]-4-carboxamide [564];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [565];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [566];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [567];

(S)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [568];

1-isobutyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [569];

(R)-1-isobutyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [570];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [571];

4-methyl-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)piperazine-1-carboxamide [572];

2-(3,3-dimethylazetidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [573];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [574];

(S)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [575];

(R)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [576];

(R)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [577];

(S)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [578];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [579];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [580];

2-(4-fluoropiperidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [581];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [582];

2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [583];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [584];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [585];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)propanamide [586];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [587];

2-(4-ethylpiperazin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [588];

2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [589];

(S)-2-(2,4-dimethylpiperazin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [590];

2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [591];

2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [592];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-morpholinoacetamide [593];

(R)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [594];

(S)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [595];

(S)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(2-methylmorpholino)acetamide [596];

(S)—N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-morpholinopropanamide [597];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(morpholin-2-yl)acetamide [598];

N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)-2-(4-methylmorpholin-2-yl)acetamide [599];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [600];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl) acetamide [601];

2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl) acetamide [602];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [603];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-fluoro-2-methylpropanamide [604];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(diethylamino)acetamide [605];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(cyclobutyl(methyl)amino)acetamide [606];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide [607];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-fluorocyclopropane-1-carboxamide [608];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-3,3-difluorocyclobutane-1-carboxamide [609];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-methyl-2-azaspiro[3.3]heptane-6-carboxamide [610];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-fluoroethyl)-2-azaspiro[3.3]heptane-6-carboxamide [611];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [612];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-7-methyl-7-azaspiro[3.5]nonane-2-carboxamide [613];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-fluorocyclohexane-1-carboxamide [614];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4,4-difluorocyclohexane-1-carboxamide [615];

trans-N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-(dimethylamino)cyclohexane-1-carboxamide [617];

trans-N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-formylcyclohexane-1-carboxamide [618];

trans-N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-(hydroxymethyl)cyclohexane-1-carboxamide [619];

trans-N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [620];

trans-N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-((3-fluoroazetidin-1-yl)methyl)cyclohexane-1-carboxamide [621];

trans-N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)cyclohexane-1-carboxamide [622];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [623];

(R)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [624];

(R)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [625];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [626];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [627];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide [628];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-fluoro-1-methylpiperidine-4-carboxamide [629];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-ethyl-4-fluoropiperidine-4-carboxamide [630];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-fluoroethyl)piperidine-4-carboxamide [631];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-fluoro-1-(2-fluoroethyl)piperidine-4-carboxamide [632];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2,2-difluoroethyl)piperidine-4-carboxamide [633];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-hydroxyethyl)piperidine-4-carboxamide [634];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-methoxyethyl)piperidine-4-carboxamide [635];

methyl 2-(4-((6-(1H-pyrazol-4-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [636];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-isopropylpiperidine-4-carboxamide [637];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-cyclopropylpiperidine-4-carboxamide [638];

(R)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-fluoropropyl)piperidine-4-carboxamide [639];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-fluoropropyl)piperidine-4-carboxamide [640];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2,2-difluoropropyl)piperidine-4-carboxamide [641];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [642];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-isobutylpiperidine-4-carboxamide [643];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [644];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-fluoro-2-methylpropyl)piperidine-4-carboxamide [645];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine carboxamide [646];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [647];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [648];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [649];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [650];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [651];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-benzoylpiperidine-4-carboxamide [652];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1′-methyl-[1,4′-bipiperidine]-4-carboxamide [653];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [654];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [655];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [656];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [657];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-isobutylpiperidine-3-carboxamide [658];

(R)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-1-isobutylpiperidine-3-carboxamide [659];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-4-methylpiperazine-1-carboxamide [661];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3,3-dimethylazetidin-1-yl)acetamide [662];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [663];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-fluoropyrrolidin-1-yl)acetamide [664];

(R)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-fluoropyrrolidin-1-yl)acetamide [665];

(R)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [666];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [667];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [668];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-azabicyclo[3.1.0]hexan-3-yl)acetamide [669];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [670];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-fluoropiperidin-1-yl)acetamide [671];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [672];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-(difluoromethyl)piperidin-1-yl)acetamide [673];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [674];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [675];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)propanamide [676];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [677];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-ethylpiperazin-1-yl)acetamide [678];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-(2-fluoroethyl)piperazin-1-yl)acetamide [679];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2,4-dimethylpiperazin-1-yl)acetamide [680];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-isopropylpiperazin-1-yl)acetamide [681];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-cyclopropylpiperazin-1-yl)acetamide [682];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-morpholinoacetamide [683];

(R)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [684];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [685];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylmorpholino)acetamide [686];

(S)—N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-morpholinopropanamide [687];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(morpholin-2-yl)acetamide [688];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylmorpholin-2-yl)acetamide [689];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(7-azabicyclo[2.2.1]heptan-7-yl)acetamide [690];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-41R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)acetamide [691];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-41S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)acetamide [692];

N-(6-(1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)acetamide [693];

2-fluoro-2-methyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)propanamide [694];

2-(diethylamino)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [695];

2-(cyclobutyl(methyl)amino)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [696];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide [697];

1-fluoro-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclopropane-1-carboxamide [698];

3,3-difluoro-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclobutane-1-carboxamide [699];

2-methyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [700];

2-(2-fluoroethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [701];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [702];

7-methyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)-7-azaspiro[3.5]nonane-2-carboxamide [703];

1-fluoro-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [704];

4,4-difluoro-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [705];

trans-4-methoxy-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [706];

trans-4-(dimethylamino)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [707];

trans-4-formyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [708];

trans-4-(hydroxymethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [709];

trans-4-morpholino-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [710];

trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [711];

trans-4-((4-methylpiperazin-1-yl)methyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [712];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)azetidine-3-carboxamide [713];

(R)—N-(6-(thiazol-5-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [714];

(R)—N-(6-(thiazol-5-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [715];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [716];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [717];

1-methyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [718];

4-fluoro-1-methyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [719];

1-ethyl-4-fluoro-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [720];

1-(2-fluoroethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [721];

4-fluoro-1-(2-fluoroethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [722];

1-(2,2-difluoroethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [723];

1-(2-hydroxyethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [724];

1-(2-methoxyethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [725];

methyl 2-(4-((6-(thiazol-5-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [726];

1-isopropyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [727];

1-cyclopropyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [728];

(R)-1-(2-fluoropropyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [729];

(S)-1-(2-fluoropropyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [730];

1-(2,2-difluoropropyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [731];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [732];

1-isobutyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [733];

4-fluoro-1-isobutyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [734];

1-(2-fluoro-2-methylpropyl)-N-(64 thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [735];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [736];

1-(oxetan-3-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [737];

14 (3-methyloxetan-3-yl)methyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [738];

1-neopentyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [739];

1-(methylsulfonyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [740];

1-(2-(pyrrolidin-1-yl)acetyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [741];

1-benzoyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [742];

1′-methyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)-[1,4′-bipiperidine]-4-carboxamide [743];

1-(tetrahydro-2H-pyran-4-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [744];

1-(oxazol-2-ylmethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [745];

1-(pyridin-2-ylmethyl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [746];

(S)—N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [747];

1-isobutyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [748];

(R)-1-isobutyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [749];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [750];

4-methyl-N-(6-(thiazol-5-yl)isoquinolin-3-yl)piperazine-1-carboxamide [751];

2-(3,3-dimethylazetidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [752];

2-(pyrrolidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [753];

(S)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [754];

(R)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [755];

(R)-2-(2-methylpyrrolidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [756];

(S)-2-(2-methylpyrrolidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [757];

2-(pyrrolidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)propanamide [758];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [759];

2-(piperidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [760];

2-(4-fluoropiperidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [761];

2-(4-methylpiperidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [762];

2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [763];

N-(6-(thiazol-5-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl)acetamide [764];

2-(6-azaspiro[2.5]octan-6-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [765];

2-(piperidin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)propanamide [766];

2-(4-methylpiperazin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [767];

2-(4-ethylpiperazin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [768];

2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [769];

(S)-2-(2,4-dimethylpiperazin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [770];

2-(4-isopropylpiperazin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [771];

2-(4-cyclopropylpiperazin-1-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [772];

2-morpholino-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [773];

(R)-2-(3-methylmorpholino)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [774];

(S)-2-(3-methylmorpholino)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [775];

(S)-2-(2-methylmorpholino)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [776];

(S)-2-morpholino-N-(6-(thiazol-5-yl)isoquinolin-3-yl)propanamide [777];

2-(morpholin-2-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [778];

2-(4-methylmorpholin-2-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [779];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [780];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [781];

2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [782];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(thiazol-5-yl)isoquinolin-3-yl)acetamide [783];

2-fluoro-2-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) propanamide [784];

2-(diethylamino)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [785];

2-(cyclobutyl(methyl)amino)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) acetamide [786];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide [787];

1-fluoro-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropane carboxamide [788];

3,3-difluoro-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclobutane carboxamide [789];

2-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [790];

2-(2-fluoroethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-azaspiro [3.3]heptane-6-carboxamide [791];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [792];

7-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-7-azaspiro[3.5]nonane-2-carboxamide [793];

1-fluoro-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [794];

trans-4-methoxy-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [795];

trans-4-(dimethylamino)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) cyclohexane-1-carboxamide [796];

trans-4-formyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [797];

trans-4-(hydroxymethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) cyclohexane-1-carboxamide [798];

trans-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [799];

trans-44 (3-fluoroazetidin-1-yl)methyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl) isoquinolin-3-yl)cyclohexane-1-carboxamide [800];

trans-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl)cyclohexane-1-carboxamide [801];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)azetidine-3-carboxamide [802];

(R)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [803];

(R)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)tetrahydrofuran carboxamide [804];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [805];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [806];

1-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine carboxamide [807];

4-fluoro-1-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [808];

1-ethyl-4-fluoro-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [809];

1-(2-fluoroethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [810];

4-fluoro-1-(2-fluoroethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [811];

1-(2,2-difluoroethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [812];

1-(2-hydroxyethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [813];

1-(2-methoxyethyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [814];

methyl 2-(4-((6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) carbamoyl)piperidin-1-yl)acetate [815];

1-isopropyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [816];

1-cyclopropyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [817];

(R)-1-(2-fluoropropyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [818];

(S)-1-(2-fluoropropyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [819];

1-(2,2-difluoropropyl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [820];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [821];

1-isobutyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine carboxamide [822];

4-fluoro-1-isobutyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [823];

1-(2-fluoro-2-methylpropyl)-N-(6 (1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [824];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [825];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [826];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl) methyl)piperidine-4-carboxamide [827];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [828];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [829];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl) piperidine-4-carboxamide [830];

1-benzoyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [831];

1′-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-[1,4′-bipiperidine]-4-carboxamide [832];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl) piperidine-4-carboxamide [833];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(oxazol-2-ylmethyl) piperidine-4-carboxamide [834];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(pyridin-2-ylmethyl) piperidine-4-carboxamide [835];

(R)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-3-carboxamide [836];

1-isobutyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine carboxamide [837];

(R)-1-isobutyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine carboxamide [838];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)tetrahydro-2H-pyran carboxamide [839];

4-methyl-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperazine-1-carboxamide [840];

2-(3,3-dimethylazetidin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) acetamide [841];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [842];

(S)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [843];

(R)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [844];

(R)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [845];

(S)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [846];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl) propanamide [847];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [848];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [849];

2-(4-fluoropiperidin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) acetamide [850];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl) acetamide [851];

2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl) isoquinolin-3-yl)acetamide [852];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl) piperidin-1-yl)acetamide [853];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl) acetamide [854];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl) propanamide [855];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl) acetamide [856];

2-(4-ethylpiperazin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) acetamide [857];

2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl) isoquinolin-3-yl)acetamide [858];

(S)-2-(2,4-dimethylpiperazin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [859];

2-(4-isopropylpiperazin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl) acetamide [860];

2-(4-cyclopropylpiperazin-1-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [861];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-morpholinoacetamide [862];

(R)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino) acetamide [863];

(S)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(3-methylmorpholino) acetamide [864];

(S)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(2-methylmorpholino)acetamide [865];

(S)—N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-morpholinopropanamide [866];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(morpholin-2-yl)acetamide [867];

N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylmorpholin-2-yl) acetamide [868];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [869];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [870];

2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [871];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(1-methyl-5-(piperidin-1-ylmethyl)-1H-pyrazol-4-yl) isoquinolin-3-yl)acetamide [872];

2-fluoro-2-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)propanamide [873];

2-(diethylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [874];

2-(cyclobutyl(methyl)amino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [875];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide [876];

1-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclopropane-1-carboxamide [877];

3,3-difluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclobutane-1-carboxamide [878];

2-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [879];

2-(2-fluoroethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [880];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane-6-carboxamide [881];

7-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-7-azaspiro[3.5]nonane-2-carboxamide [882];

1-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [883];

4,4-difluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [884];

trans-4-methoxy-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [885];

trans-4-(dimethylamino)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [886];

trans-4-formyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [887];

trans-4-(hydroxymethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclohexane carboxamide [888];

trans-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [889];

trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl) cyclohexane-1-carboxamide [890];

trans-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-4-((4-methylpiperazin-1-yl)methyl) cyclohexane-1-carboxamide [891];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)azetidine-3-carboxamide [892];

(R)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [893];

(R)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [894];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [895];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [896];

1-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [897];

4-fluoro-1-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [898];

1-ethyl-4-fluoro-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [899];

1-(2-fluoroethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [900];

4-fluoro-1-(2-fluoroethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [901];

1-(2,2-difluoroethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [902];

1-(2-hydroxyethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [903];

1-(2-methoxyethyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [904];

methyl 2-(4-((6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [905];

1-isopropyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [906];

1-cyclopropyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [907];

(R)-1-(2-fluoropropyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [908];

(S)-1-(2-fluoropropyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [909];

1-(2,2-difluoropropyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [910];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [911];

1-isobutyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [912];

4-fluoro-1-isobutyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [913];

1-(2-fluoro-2-methylpropyl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [914];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [915];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-(oxetan-3-yl)piperidine-4-carboxamide [916];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-((3-methyloxetan-3-yl)methyl)piperidine-4-carboxamide [917];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-neopentylpiperidine-4-carboxamide [918];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-(methylsulfonyl)piperidine-4-carboxamide [919];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [920];

1-benzoyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [921];

1′-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-[1,4′-bipiperidine]-4-carboxamide [922];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)piperidine-4-carboxamide [923];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-(oxazol-2-ylmethyl)piperidine-4-carboxamide [924];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-(pyridin-2-ylmethyl)piperidine-4-carboxamide [925];

(S)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-3-carboxamide [926];

1-isobutyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-3-carboxamide [927];

(R)-1-isobutyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperidine-3-carboxamide [928];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [929];

4-methyl-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)piperazine-1-carboxamide [930];

2-(3,3-dimethylazetidin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [931];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [932];

(S)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [933];

(R)-2-(3-fluoropyrrolidin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [934];

(R)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [935];

(S)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(2-methylpyrrolidin-1-yl)acetamide [936];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [937];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl) acetamide [938];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [939];

2-(4-fluoropiperidin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [940];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(4-methylpiperidin-1-yl)acetamide [941];

2-(4-(difluoromethyl)piperidin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl) acetamide [942];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(4-(trifluoromethyl)piperidin-1-yl) acetamide [943];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [944];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)propanamide [945];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [946];

2-(4-ethylpiperazin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [947];

2-(4-(2-fluoroethyl)piperazin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl) acetamide [948];

(S)-2-(2,4-dimethylpiperazin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl) acetamide [949];

2-(4-isopropylpiperazin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [950];

2-(4-cyclopropylpiperazin-1-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [951];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-morpholinoacetamide [952];

(R)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [953];

(S)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(3-methylmorpholino)acetamide [954];

(S)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(2-methylmorpholino)acetamide [955];

(S)—N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-morpholinopropanamide [956];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(morpholin-2-yl)acetamide [957];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(4-methylmorpholin-2-yl)acetamide [958];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl) acetamide [959];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl) isoquinolin yl)acetamide [960];

2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl) isoquinolin-3-yl)acetamide [961];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl) acetamide [962];

N-(8-fluoro-6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-morpholinoacetamide [963];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(phenylsulfonyl)piperidine-4-carboxamide [964];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-(methyl-d3)piperazin-1-yl)acetamide [965];

N-(7-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide [966];

1-ethyl-N-(7-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [967];

N-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [968];

N-(6-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexanecarboxamide [969];

N-(6-(isothiazol-4-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide [970];

(S)—N-(6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [971];

1-isobutyl-N-(6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [972];

N-(6-(oxazol-5-yl)isoquinolin-3-yl)cyclopropanecarboxamide [973];

(R)—N-(6-(oxazol-5-yl)isoquinolin-3-yl)tetrahydrofuran-2-carboxamide [974];

(R)—N-(6-(oxazol-5-yl)isoquinolin-3-yl)piperidine-3-carboxamide [975];

N-(6-(oxazol-5-yl)isoquinolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [976];

N-(6-(oxazol-5-yl)isoquinolin-3-yl)-1-(2-(pyrrolidin-1-yl)acetyl)piperidine-4-carboxamide [977];

1′-methyl-N-(6-(oxazol-5-yl)isoquinolin-3-yl)-[1,4′-bipiperidine]-4-carboxamide [978];

cis-4-morpholino-N-(6-(oxazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [979];

2-(cyclobutyl(methyl)amino)-N-(6-(oxazol-5-yl)isoquinolin-3-yl)acetamide [980];

N-(6-(oxazol-5-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [981];

(R)-2-(2-methylpyrrolidin-1-yl)-N-(6-(oxazol-5-yl)isoquinolin-3-yl)acetamide [982];

2-(4-methylpiperazin-1-yl)-N-(6-(oxazol-5-yl)isoquinolin-3-yl)acetamide [983];

N-(6-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)tetrahydro-2H-pyran carboxamide [984];

N-(6-(5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide 3,3-difluoro-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)cyclobutane carboxamide [986];

(R)—N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)pyrrolidine-2-carboxamide [987];

(R)—N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)piperidine-3-carboxamide [988];

1-methyl-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide [989];

N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [990];

1-benzoyl-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide [991];

N-(6-(2-methylthiazol-5-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [993];

N-(6-(2-methylthiazol-5-yl)isoquinolin-3-yl)-2-morpholinoacetamide [994];

2-(4-methylpiperazin-1-yl)-N-(6-(2-methylthiazol-5-yl)isoquinolin-3-yl)acetamide [995];

2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(2-methylthiazol-5-yl)isoquinolin-3-yl) acetamide [996];

N-(6-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [997];

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)-1-((1-(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [998];

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide [999];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)acetamide [1000];

cis-4-methoxy-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [1001];

(R)—N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl) isobutylpiperidine-3-carboxamide [1002];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(pyrimidin-2-ylmethyl)piperidine-4-carboxamide [1003];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(pyrazin-2-ylmethyl)piperidine-4-carboxamide [1004];

1-((5-methyl-1,2,4-oxadiazol-3-yl)methyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl) piperidine-4-carboxamide [1005];

1-(2-hydroxy-2-methylpropyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1006];

trans-4-((4-methylpiperazin-1-yl)methyl)-N-(6-(oxazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [1007];

2-isopropoxy-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)acetamide [1008];

3-isopropoxy-N-(6-(1-methyl-1H-imidazol-5-yl)isoquinolin-3-yl)propanamide [1009];

tert-butyl 2-(4-((6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetate [1010];

2-(4-((6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)carbamoyl)piperidin-1-yl)acetic acid [1011];

2-(4-methyl-1,4-diazepan-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [1012];

N-(7-chloro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1013];

N-(6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [1014];

N-(7-fluoro-6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [1015];

N-(8-fluoro-6-(1-(methyl-d3)-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [1016];

trans-4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [1017];

trans-4-((3-fluoroazetidin-1-yl)methyl)-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [1018];

N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [1019];

1-isobutyl-N-(6-(5-methyl-1,3,4-oxadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1020];

4-fluoro-1-isobutyl-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1021];

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1022];

4-fluoro-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)-1-isobutylpiperidine-4-carboxamide [1023];

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [1024];

tert-butyl (6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)carbamate [1025];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)but-2-ynamide [1026];

N-(7-chloro-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide [1027];

N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [1028];

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)acetamide [1029];

(R)-2-(2-methylpyrrolidin-1-yl)-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)acetamide [1030];

2-(cyclobutyl(methyl)amino)-N-(6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)isoquinolin-3-yl)acetamide [1031];

trans-4-((6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)carbamoyl)cyclohexane-1-carboxylic acid [1032];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide-2,2-d2 [1033];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-3-morpholinopropanamide [1034];

trans-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-3-morpholinocyclobutane-1-carboxamide [1035];

1-(1-isobutylpiperidin-4-yl)-3-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)urea [1036];

1-methyl-3-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(1-methylpiperidin-4-yl)urea [1037];

1-isobutyl-N-(6-(4-methyl-4H-1,2,4-triazol-3-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1038];

1-isobutyl-N-(6-(1-methyl-1H-tetrazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1039];

N-(6-(2-(methylamino)thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1040];

1-methyl-N-(6-(2-(methylamino)thiazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1041];

N-(6-(2-(dimethylamino)thiazol-5-yl)isoquinolin-3-yl)quinuclidine-4-carboxamide [1042];

N-(6-(2-(dimethylamino)thiazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [1043];

N-(6-(2-(dimethylamino)thiazol-5-yl)isoquinolin-3-yl)-2-(4-fluoropiperidin-1-yl)acetamide [1044];

N-(6-(2-(dimethylamino)thiazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [1045];

N-(6-(2-(diethylamino)thiazol-5-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide [1046];

N-(6-(2-(diethylamino)thiazol-5-yl)isoquinolin-3-yl)-2-(4-fluoropiperidin-1-yl)acetamide [1047];

N-(6-(2-(diethylamino)thiazol-5-yl)isoquinolin-3-yl)-2-(4-methylpiperazin-1-yl)acetamide [1048];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(1,4-oxazepan-4-yl)acetamide [1049];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(piperidin-1-yl)acetamide-2,2-d2 [1050];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-morpholinoacetamide-2,2-d2 [1051];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(morpholino-d8)acetamide [1052];

N-(7-fluoro-6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-morpholinoacetamide [1053];

N-(6-(5-(dimethylamino)-1,3,4-thiadiazol-2-yl) isoquinolin-3-yl)piperidine-4-carboxamide [1054];

N-(6-(5-(dimethylamino)-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide [1055];

N-(6-(5-(dimethylamino)-1,3,4-thiadiazol-2-yl) isoquinolin-3-yl)quinuclidine-4-carboxamide [1056];

1-(2,2-difluoropropyl)-N-(6-(oxazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1057];

14 (3-methyloxetan-3-yl)methyl)-N-(6-(oxazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1058];

4-methyl-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)piperazine-1-carboxamide [1059];

trans-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-3-(4-methylpiperazin-1-yl)cyclobutane-1-carboxamide [1060];

trans-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-3-morpholinocyclobutane-1-carboxamide [1061];

trans-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-3-(morpholinomethyl)bicyclo[1.1.1]pentane-1-carboxamide [1062];

trans-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-3-((4-methylpiperazin-1-yl)methyl)bicycle [1.1.1]pentane-1-carboxamide [1063];

trans-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-4-morpholinocyclohexane-1-carboxamide [1064];

trans-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-4-(4-methylpiperazin-1-yl)cyclohexane-1-carboxamide [1065];

(S)—N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)propanamide [1066];

N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-2-morpholinoacetamide [1067];

N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-3-morpholinopropanamide [1068];

N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)-3-(4-methylpiperazin-1-yl)propanamide [1069];

1-(2-hydroxy-2-methylpropyl)-N-(6-(5-methyl-1,3,4-oxadiazol-2-yl) isoquinolin-3-yl)piperidine-4-carboxamide [1070];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)quinuclidine-4-carboxamide [1071];

1-(2-hydroxy-2-methylpropyl)-N-(6-(1-methyl-1H-1,2,3-triazol-4-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1072];

N-(6-(2H-1,2,3-triazol-2-yl)isoquinolin-3-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [1073];

N-(6-(1H-1,2,3-triazol-1-yl)isoquinolin-3-yl)-4-fluoro-1-isobutylpiperidine-4-carboxamide [1074];

N-(6-(5-(Dimethylamino)-1,3,4-oxadiazol-2-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1075];

N-(6-(5-(Dimethylamino)-1,3,4-oxadiazol-2-yl)isoquinolin-3-yl)-1-methylpiperidine-4-carboxamide [1076];

2-(4-Methoxypiperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [1077];

2-(4-Hydroxypiperidin-1-yl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)acetamide [1078];

1-Isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azepane-4-carboxamide [1079];

1-Methyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)azepane-4-carboxamide [1080];

cis-4-(Dimethylamino)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [1081];

cis-4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [1082];

3-(hydroxymethyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)bicyclo[1.1.1]pentane-1-carboxamide [1083];

methyl trans-4-((6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)carbamoyl)cyclohexane-1-carboxylate [1084];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl-1-d)piperidine-4-carboxamide [1085];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-1-(2-(methyl-d 3 )propyl-1, 1,2,3,3,3-d))piperidine-4-carboxamide [1086];

1-isobutyl-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl-1-d)piperidine-4-carboxamide [1087];

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-3-((4-methylpiperazin-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide [1088];

N-(6-(5-methyl-1,3,4-thiadiazol-2-yl)isoquinolin-3-yl)-2-(pyrrolidin-1-yl)acetamide-2,2-d 2 [1089];

1-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-3-(1-methylpiperidin-4-yl)urea [1090];

trans-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)-4-(4-methylpiperazine-1-carbonyl) cyclohexane-1-carboxamide [1091];

1-isobutyl-N-(6-(1-methyl-1H-tetrazol-5-yl)isoquinolin-3-yl)piperidine-4-carboxamide [1092]; and

N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl-1-d)-2-(pyrrolidin-1-yl)acetamide [1093]; or a pharmaceutically acceptable salt thereof.

40. The method of claim 1 , wherein the compound of Formula I is selected from the group consisting of:

N-(6-(1-Methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclopropanecarboxamide [1];

4,4-Difluoro-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane-1-carboxamide [3];

trans-4-((3-Fluoroazetidin-1-yl)methyl)-N-(6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-yl)cyclohexane carboxamide [10];