IP Library › Patent Application 17515473
Patent Application
App. No. 17/515,473

METHOD FOR THE CYTOLOGICAL ANALYSIS OF CERVICAL CELLS

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Patent No.
US None
App. No.
17/515,473
Abstract

The invention provides for a diagnostic test to monitor cancer-specific genetic abnormalities to diagnose cervical cell disorders and predict which patients might progress to cancer. Genetic abnormalities are detected by identification in chromosomal copy number of chromosome 3 and chromosome 5 using FISH analysis of probes targeted to 3q and/or 5p.

Claims (30)

1 - 35 . (canceled)

36 . A composition consisting of a plurality of amplification primer pairs, wherein each primer pair individually amplifies a chromosomal location selected from:

(a) at least one of LRRIQ4, LRRC31, SAMD7, LOC100128164, SEC62, GPR160, PHC3, or PRKCI; and

(b) either CEP3 or CEN7; and

(c) at least one of ADCY2, C5orf49, FASTKD3, MTRR, SEMA5A, SNORD123, TAS2R1, LOC285692, FAM173B, CCT5, CMBL, MARCH6, ROPNIL, DAP, or CTNND2; and

optionally, wherein the chromosomal location further consists of 20q13.

37 . The composition of claim 36 , wherein (a) is LRRIQ4.

38 . The composition of claim 36 , wherein (a) is LRRC31.

39 . The composition of claim 36 , wherein (a) is SAMD7.

40 . The composition of claim 36 , wherein (a) is LOC100128164.

41 . The composition of claim 36 , wherein (a) is SEC62.

42 . The composition of claim 36 , wherein (a) is GPR160.

43 . The composition of claim 36 , wherein (a) is PHC3.

44 . The composition of claim 36 , wherein (a) is PRKCI.

45 . The composition of claim 36 , wherein (a) is at least two of LRRIQ4, LRRC31, SAMD7, LOC100128164, SEC62, GPR160, PHC3, or PRKCI.

46 . The composition of claim 45 , wherein (a) is GPR160 and PHC3.

47 . The composition of claim 45 , wherein (a) is at least three of LRRIQ4, LRRC31, SAMD7, LOC100128164, SEC62, GPR160, PHC3, or PRKCI.

48 . The composition of claim 47 , wherein (a) is GPR160, PHC3, and PRKCI.

49 . The composition of claim 47 , wherein (a) is SAMD7, LOC100128164, SEC62, GPR160, and PHC3.

50 . The composition of claim 47 , wherein (a) is LRRIQ4, LRRC31, SAMD7, LOC100128164, SEC62, GPR160 and PHC3.

51 . The composition of claim 47 , wherein (a) is LRRIQ4, LRRC31, and SAMD7.

52 . The composition of claim 47 , wherein (a) is LRRIQ4, LRRC31, SAMD7, LOC100128164, and SEC62.

53 . The composition of claim 36 , wherein (c) is SEMA5A.

54 . The composition of claim 36 , wherein (c) is CTNND2.

55 . The composition of claim 36 , wherein (a) is GPR160 and PHC3, (b) is CEN7 and (c) is SEMA5A.

56 . The composition of claim 36 , wherein (a) is LRRIQ4, LRRC31, and SAMD7, (b) is CEN7 and (c) is SEMA5A.

57 . The composition of claim 36 , wherein (b) is CEN7 and (c) is CTNND2.

58 . The composition of claim 36 , wherein (b) is CEN7 and (c) is SNORD123 or TAS2R1.

59 . The composition of claim 36 , wherein the chromosome location further consists of 20q13.

60 . The composition of claim 36 , wherein each primer pair is labeled.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 27, 2023
From: ENDRESS, GREGORY ANTON; LIGHT, ELIZABETH; UPDENDER, MADHVI; CAIN, COLYN
To: NEODIAGNOSTIX, INC.
Reel/Frame 063780/0843 →