Ophthalmic device for drug delivery
An ophthalmic implant for drug delivery. The implant includes a primary intracapsular device coupled to a secondary device, wherein, when implanted in a patient's eye, the primary intracapsular device is held in place by the patient's capsular bag and the secondary device is held in place by the primary intracapsular device. The implant may be inserted in the eye by injecting the primary intracapsular device into the eye either before or after attaching the secondary device to the primary intracapsular device, and subsequently positioning the joined secondary device and primary intracapsular device with the primary intracapsular device held in place by the patient's capsular bag and the secondary device held in place by the primary intracapsular device. The secondary device may be designed to hold a tertiary device that can be implanted and attached at the time of surgery or anytime postoperatively.
1 . An ophthalmic implant, comprising:
a primary intracapsular device comprising an intraocular structure and at least one haptic comprising a first haptic being unitarily formed with and extending outwards from the intraocular structure at a first junction of the first haptic and the intraocular structure, the intraocular structure comprising an optical axis; and
a secondary intracapsular device comprising at least one drug delivery device comprising a first drug delivery device configured to attach to the first haptic, the first drug delivery device comprising a first pad including a first planar anterior surface that lies in a first plane that is perpendicular to the optical axis when attached to the first haptic, and
wherein the first pad comprises a first polymer material and at least a first therapeutic agent.
2 . The ophthalmic implant of claim 1 , wherein the at least one haptic further comprises a second haptic being unitarily formed with and extending outwards from the intraocular structure at a second junction of the second haptic and the intraocular structure, and wherein the at least one drug delivery device further comprises a second drug delivery device configured to attach to the second haptic, the second drug delivery device comprises a second pad comprising a second polymer material and at least a second therapeutic agent.
3 . The ophthalmic implant of claim 2 , wherein the second pad includes a second planar anterior surface.
4 . The ophthalmic implant of claim 2 , wherein the intraocular structure lies in a second plane that is parallel to the first plane, and wherein the second pad lies in the first plane.
5 . The ophthalmic implant of claim 1 , wherein the first drug delivery device is configured to release the at least first therapeutic agent for a period of at least six (6) months.
6 . The ophthalmic implant of claim 1 , wherein the first drug delivery device comprises an outer layer comprising a silicone material.
7 . The ophthalmic implant of claim 1 , wherein the intraocular structure further comprises a first surface feature at the first junction, the first drug delivery device configured to be retained in position by the first surface feature.
8 . The ophthalmic implant of claim 7 , wherein the first surface feature is a first flare.
9 . The ophthalmic implant of claim 8 , wherein the first surface feature is configured to resist outward movement of the first drug delivery device relative to the intraocular structure.
10 . The ophthalmic implant of claim 1 , wherein the at least first therapeutic agent comprises at least one prostaglandin analog.
11 . The ophthalmic implant of claim 1 , wherein the intraocular structure comprises an intraocular lens.
12 . The ophthalmic implant of claim 1 , wherein the intraocular structure comprises an intraocular scaffold devoid of a lens.
13 . A method comprising:
implanting the ophthalmic implant of claim 1 into an eye of a subject.
14 . The ophthalmic implant of claim 1 , wherein the first drug delivery device is embedded in an outer shell.
15 . The ophthalmic implant of claim 14 , wherein the outer shell comprises a polymer material.
16 . The ophthalmic implant of claim 15 , wherein the polymer material is silicone.
17 . The ophthalmic implant of claim 1 , wherein a portion of the first pad is permeable.
18 . The ophthalmic implant of claim 17 , wherein the portion of the first pad is an entirety of the first pad.
19 . The ophthalmic implant of claim 1 , wherein the first planar anterior surface extends across an entirety of an anterior-facing side of the first pad.