Protein activity modification
A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.
1. A method of treating a cardiac disorder in a heart of a patient, comprising:
selecting a patient with a risk of progression of heart failure;
assessing a baseline value of one or more anatomical markers; and
applying a non-excitatory signal to said heart of said patient during a refractory period of said heart for a duration sufficient to reverse or reduce the progression of one or more anatomical markers;
wherein the one or more anatomical markers include one or more of interstitial fibrosis, Volume fraction of replacement fibrosis (VFRF), Volume Fraction of Interstitial Fibrosis (VFIF), cardiomyocyte cross sectional area, capillary density and oxygen diffusion distance.
2. A method according to claim 1 , wherein said anatomical markers includes interstitial fibrosis.
3. A method according to claim 2 , wherein said applying comprises applying said signal in a manner which inhibits one or more gelatinases.
4. A method according to claim 3 , wherein said one or more gelatinases include one or both of the Matrix Metalloproteinases MMP2 and MMP9.
5. A method according to claim 1 , wherein the anatomical markers include capillary density and oxygen diffusion distance and said applying normalizes one or both of capillary density and oxygen diffusion distance.
6. A method according to claim 1 , wherein the anatomical markers include said VFRF and said applying improves said VFRF (Volume fraction of replacement fibrosis) by at least 23%.
7. A method according to claim 1 , wherein the anatomical markers include said VFIF and said applying improves said VFIF (Volume Fraction of Interstitial Fibrosis) by at least 16%.
8. A method according to claim 1 , wherein said reduces cardiomyocyte cross-sectional area by at least 19%.
9. A method according to claim 1 , wherein said applying causes a reduction in myocardial oxygen consumption (MVO2) by at least 96 micromol/min.
10. A method according to claim 1 , wherein said selecting comprises selecting a patient with an aim of increasing LV diastolic compliance.
11. A method according to claim 1 , wherein said applying comprises applying said non-excitatory signal with every heart beat.
12. A method according to claim 11 , wherein said applying comprises applying said non-excitatory signal about 80 applications per minute.
13. A method according to claim 11 , wherein said applying comprises applying said non-excitatory signal between 4 and 6 phases.
14. A method according to claim 11 , wherein said applying comprises applying to a right ventricular septum to treat a damaged left ventricle.
15. A method according to claim 14 , wherein said applying comprises applying said non-excitatory signal using two electrodes about 1-2 cm apart.
16. A method according to claim 11 , wherein said applying comprises applying for about 5 hours a day.
17. A method according to claim 1 , wherein said applying of the signal lasts for a duration for at least 3 months.