TEXTURED SURFACES FOR IMPLANTS
An implant material having an implant surface comprising a plurality of tissue-contacting members arranged in a regular or irregular two-dimensional array, each tissue-contacting member having a convex curved tissue-contacting surface. Methods of preparing and using such implant materials.
1 - 21 . (canceled)
22 . A prosthetic implant comprising a biocompatible material, the implant having an implant surface with a biomimetic topography comprising a plurality of tissue-contacting members, each tissue-contacting member having a convex curved surface, wherein the mean average height value of the plurality of tissue-contacting members is in the range of 5 μm to 150 μm.
23 . The implant of claim 22 , wherein the mean average height value of the plurality of tissue-contacting members is in the range of 15 μm to 90 μm.
24 . The implant of claim 22 , wherein the implant is a breast implant.
25 . The implant of claim 22 , wherein the tissue-contacting members are hemispherical in shape.
26 . The implant of claim 22 , wherein the height of at least 30% of the population of the tissue-contacting members fall within a range of 15 μm to 90 μm.
27 . The implant of claim 22 , wherein the mean average diameter of the plurality of tissue-contacting members is in the range of 1 μm to 120 μm.
28 . The implant of claim 22 , wherein the implant surface has at least 500 tissue-contacting members per cm 2 .
29 . The implant of claim 22 , wherein the tissue-contacting surfaces of the plurality of tissue-contacting members comprise nano-scale features having a height in the range of 200 nm to 800 nm.
30 . The implant of claim 22 , wherein the plurality of tissue-contacting members cover at least 20% of the implant surface.
31 . The implant of claim 22 , wherein each tissue-contacting member has at least four neighboring tissue-contacting members.
32 . The implant of claim 22 , wherein the tissue-contacting members are discrete members spaced from each other, or members that are merged or fused together.
33 . The implant of claim 22 , wherein the implant surface is a closed surface substantially free of pores or other open structures.
34 . A prosthetic implant comprising a biocompatible material, the implant having an implant surface comprising a plurality of tissue-contacting members, each tissue-contacting member having a convex curved surface, wherein the mean average height value of the plurality of tissue-contacting members is in the range of 15 μm to 90 μm, and wherein the implant surface is a closed surface substantially free of pores or other open structures.
35 . The implant of claim 34 , wherein the implant is a breast implant.
36 . The implant of claim 34 , wherein the implant surface has at least 500 tissue-contacting members per cm 2 .
37 . The implant of claim 34 , wherein each tissue-contacting member has at least four neighboring tissue-contacting members within a distance of 2× the width of the tissue-contacting member.
38 . A prosthetic implant comprising a biocompatible material, the implant having an implant surface with a biomimetic topography comprising a plurality of tissue-contacting members, each tissue-contacting member having a convex curved surface, wherein the mean average height value of the plurality of tissue-contacting members is in the range of 5 μm to 150 μm and the mean average diameter of the plurality of tissue-contacting members is from 1 μm to 120 μm, and wherein implant surface comprises an organosilicon polymer.
39 . The implant of claim 38 , wherein the implant surface has 1000 to 50000 tissue-contacting members per cm 2 .
40 . The implant of claim 38 , wherein the implant is a breast implant.
41 . The implant of claim 38 , wherein the plurality of tissue-contacting members is a plurality of truncated hemispheres arranged to form a two-dimensional array of fused hemispheres.