Treatment of hematological disorders
The invention relates to compositions and methods for treating patients with hematological proliferative disorders with CPX-351, a liposomal composition of daunorubicin and cytarabine, and venetoclax.
1. A method to treat a hematologic proliferative disorder in a subject, which method comprises administering to said subject a pharmaceutical composition comprising CPX-351 that supplies daunorubicin and cytarabine in a treatment cycle in combination with venetoclax, wherein the subject is receiving either a strong or moderate CYP3A inhibitor.
2. The method of claim 1 , CPX-351 is administered intravenously on days 1, 3, and 5 and venetoclax is administered orally on days 2-21 on a 28 day cycle.
3. The method of claim 1 , CPX-351 is administered intravenously on days 1 and 3 and venetoclax is administered orally on days 2-21 on a 28 day cycle.
4. The method of claim 1 , wherein the hematologic proliferative disorder is acute lymphocytic leukemia, acute myeloid leukemia, chronic myelogenous leukemia, chronic lymphocytic leukemia or acute promyelocytic leukemia, myelodysplastic syndrome or myeloproliferative neoplasm.