Borate ester complexes of α-hydroxy carboxylic acids and their conjugate base buffers
A composition is provided for use as a buffer in personal care and pharmaceutical formulations. The composition comprises complex esters of boric acid and simple α-hydroxy carboxylic acids, and the corresponding basic conjugate salts of complex esters of boric acid and simple α-hydroxy carboxylic acids. The weight of boric acid and α-hydroxy acid is up to about 1.0% by weight (w/w %) of the composition. The molar ratio of boric acid to α-hydroxy acid is between about 1:1 and about 1:2. The composition may be formulated for topical application. Formulations comprising the composition include a personal lubricant, wound cream, feminine cleansing douche, moisturizing lotion, a wipe, and a cleansing wash. A method of treating the skin is also provided, the method comprising the step of topically applying onto the skin an effective amount of the composition.
1. A composition for use as a buffer in personal care and pharmaceutical formulations, the composition comprising:
esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms; and
corresponding basic conjugate salts of esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms, wherein the molar ratio of boric acid to α-hydroxy acid is between about 1:1 and about 1:2, and
wherein the weight of boric acid and α-hydroxy acid is up to about 1.0% by weight (w/w %) of the composition.
2. A composition for use as a buffer in personal care and pharmaceutical formulations, the composition comprising:
esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms; and
corresponding basic conjugate salts of esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms, wherein the molar ratio of boric acid to α-hydroxy acid is between about 1:1 and about 1:2, and
wherein the weight of boric acid and α-hydroxy acid is up to about 0.5% by weight (w/w %) of the composition.
3. A composition for use as a buffer in personal care and pharmaceutical formulations, the composition comprising:
esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms; and
corresponding basic conjugate salts of esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms, wherein the molar ratio of boric acid to α-hydroxy acid is between about 1:1 and about 1:2, and
wherein the weight of boric acid and α-hydroxy acid is up to about 0.4% by weight (w/w %) of the composition.
4. A composition for use as a buffer in personal care and pharmaceutical formulations, the composition comprising:
esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms; and
corresponding basic conjugate salts of esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms,
wherein the molar ratio of boric acid to α-hydroxy acid is between about 1:1.2 and about 1:1.8.
5. A composition for use as a buffer in personal care and pharmaceutical formulations, the composition comprising:
esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms; and
corresponding basic conjugate salts of esters of boric acid and α-hydroxy monocarboxylic acids having 2 to 12 carbon atoms,
wherein the molar ratio of boric acid to α-hydroxy acid is between about 1:1.4 and about 1:1.6.
6. A formulation for topical application for use as a personal lubricant, the formulation comprising the composition as recited in claim 1 up to about 1% by weight of the formulation, and further comprising
sodium benzoate up to about 0.50% by weight of the formulation,
xanthan gum up to about 1.0% by weight of the formulation,
hyaluronic acid up to about 0.5% by weight of the formulation, and
aloe vera gel up to about 0.5% by weight of the formulation.
7. The personal lubricant formulation as recited in claim 6 , wherein the composition comprises a boric acid lactic acid ester buffer.
8. A formulation for use as a wound cream, the formulation comprising the composition as recited in claim 1 up to about 1% by weight of the formulation, and further comprising
glycerin up to about 5% by weight of the formulation,
dipalmitoylethyl hydroxyethylmonium methosulfate up to about 3% by weight of the formulation,
emulsifying wax up to about 3.5% by weight of the formulation,
isopropyl myristate up to about 3% by weight of the formulation,
dimethicone up to about 1.25% by weight of the formulation,
cetyl alcohol up to about 2% by weight of the formulation,
lanolin up to about 2% by weight of the formulation, and
potassium chloride up to about 0.35% by weight of the formulation.
9. The wound cream formulation as recited in claim 8 , wherein the composition comprise a boric acid lactic acid ester buffer.
10. A formulation for use as a feminine cleansing douche, the formulation comprising the composition as recited in claim 1 up to about 5% by weight of the formulation, and further comprising
sodium benzoate up to about 1% by weight of the formulation,
edetate disodium up to about 0.5% by weight of the formulation, and
vinegar up to about 0.5% by weight of the formulation.
11. The feminine cleansing douche formulation as recited in claim 10 , wherein the composition comprises a boric acid lactic acid ester buffer.
12. A formulation for use as a moisturizing lotion, the formulation comprising the composition as recited in claim 1 up to about 4% by weight of the formulation, and further comprising
acrylates up to about 0.55% by weight of the formulation,
sunflower seed oil up to about 1% by weight of the formulation,
PEG 40 HCO up to about 0.5% by weight of the formulation,
aminomethyl propanol 2000 up to about 0.9% by weight of the formulation,
sorbitol monolaurate up to about 1% by weight of the formulation,
hemisqualane up to about 2.5% by weight of the formulation, and
phenoxyethanol up to about 0.75% by weight of the formulation.
13. The moisturizing lotion formulation as recited in claim 12 , wherein the acrylates comprise C10-C30 alkyl acrylate crosspolymer.
14. The moisturizing lotion formulation as recited in claim 12 , wherein the composition comprises a boric acid lactic acid ester buffer.
15. A formulation for use as a wipe, the formulation comprising the composition as recited in claim 1 up to about 1.13% by weight of the formulation, and further comprising
decyl glucoside up to about 1% by weight of the formulation,
sodium benzoate up to about 0.5% by weight of the formulation, and
edetate disodium up to about 0.5% by weight of the formulation.
16. The wipe formulation as recited in claim 15 , wherein the composition comprises a boric acid lactic acid ester buffer.
17. A formulation for use as a cleansing wash, the formulation comprising the composition as recited in claim 1 up to about 10% by weight of the formulation, and further comprising
sodium c14-c16 olefin sulfonate up to about 20% by weight of the formulation,
cocamidopropyl hydroxy sultaine up to about 15% by weight of the formulation,
sodium methyl cocoyl taurate up to about 5% by weight of the formulation,
Guar Hydroxypropyl Trimonium Chloride up to about 0.05% by weight of the formulation,
sodium benzoate up to about 1% by weight of the formulation, and
sodium chloride up to about 1% by weight of the formulation.
18. The cleansing wash formulation as recited in claim 17 , wherein the composition comprises a boric acid lactic acid ester buffer.
19. A method of treating the skin comprising the step of topically applying onto the skin an effective amount of the composition as recited in claim 1 .
20. The composition as recited in claim 1 , wherein the composition is in the acidic range of about 3.8-5.8 and the corresponding salts are in the basic range of about 8.2-10.2.
21. The composition as recited in claim 1 , wherein the composition is in the acidic range of about 4.0-5.5 and the corresponding salts are in the basic range of about 8.4-9.9.