Granted Patent B2

US 12,266,111 · App. 17/534,503 · Granted Apr 1, 2025

Inventors: Benj Thomas (Eden Prairie, MN); Samuel Peterson (Topanga, CA); John D. Newell, Jr. (Port Townsend, WA)

Assignee: Vida Diagnostics, Inc.

G06T7/0016A61B6/50G06F18/2413G06T7/50G06T2207/20081G06T2207/20092G06T2207/30061

Abstract

Claims (51)

1. A method for visualizing sub-pleural regions of an anatomical structure of interest from a set of volumetric data comprising:

receiving the set of volumetric data representative of the anatomical structure of interest, wherein:

the volumetric data representative of the anatomical structure of interest comprises:

volumetric data representative of an outer surface of the anatomical structure of interest; and

volumetric data representative of each of a plurality of sub-pleural regions of the anatomical structure of interest, the volumetric data representative of each of the plurality of sub-pleural regions being a region of the volumetric data representative of the anatomical structure of interest which is distant from the outer surface by a corresponding sub-pleural depth;

determining a first sub-pleural depth;

determining a first sub-pleural region of the plurality of sub-pleural regions of the anatomical structure of interest based on the determined first sub-pleural depth, the first sub-pleural region being distant from the outer surface of the anatomical structure of interest by the first sub-pleural depth;

based on the determined first sub-pleural region, extracting, from the set of volumetric data, the volumetric data representative of the first sub-pleural region; and

rendering a display image based upon the extracted volumetric data representative of the first sub-pleural region.

2. The method of claim 1 , wherein determining the first sub-pleural depth region-comprises receiving a first depth value.

3. The method of claim 2 , wherein receiving the first depth value comprises receiving a selection of the first depth value from a physician via a user interface.

4. The method of claim 2 , wherein the first depth value is selectable from a plurality of depth values.

5. The method of claim 1 , further comprising presenting the display image to a physician via a display.

6. The method of claim 5 , further comprising:

determining one or more additional features; and

presenting the one or more additional features along with the display image.

7. The method of claim 6 , wherein the one or more additional features comprises

one or more of disease phenotype and disease severity for one or more locations of the

displayed portions of the anatomical structure of interest.

8. The method of claim 6 , further comprising:

receiving a plurality of datasets, each of the plurality of datasets comprising volumetric images with known disease phenotypes and/or disease severity; and

determining the one or more additional features comprises:

comparing the volumetric data representative of the first sub-pleural region to the received plurality of datasets; and

classifying disease phenotypes and/or disease severity in the first sub-pleural region based on the comparisons with the received plurality of datasets.

9. The method of claim 8 , wherein comparing the volumetric data representative of the first sub-pleural region to the received plurality of datasets comprises using a training algorithm.

10. The method of claim 9 , wherein the training algorithm is configured to recognize characteristics present in the volumetric data representative of the first sub-pleural region based on characteristics present in the plurality of datasets.

11. A non-transitory computer readable medium programmed with instructions to cause one or more processors to:

receive a set of volumetric data representative of an anatomical structure of interest comprising volumetric data representative of an outer surface of the anatomical structure of interest and volumetric data representative of each of a plurality of sub-pleural regions of the anatomical structure of interest, the volumetric data representative of each of the plurality of sub-pleural regions being a region of the volumetric data representative of the anatomical structure of interest which is distant from the outer surface by a corresponding sub-pleural depth;

determine a first sub-pleural depth;

determine a first sub-pleural region of the plurality of sub-pleural regions of the anatomical structure of interest based on the determined first sub-pleural depth, the first sub-pleural region being distant from the outer surface of the anatomical structure of interest by the first sub-pleural depth;

based on the determined first sub-pleural region, extract, from the set of volumetric data, the volumetric data representative of the first sub-pleural region; and

render a display image based upon the extracted volumetric data representative of the first sub-pleural region.

12. The non-transitory computer readable medium of claim 11 , wherein the one or more processors are further caused to render a plurality of display images.

13. The non-transitory computer readable medium of claim 12 ,

wherein the set of volumetric data includes volumetric data taken at different points in time, and wherein the plurality of display images comprises display images of the anatomical structure of interest taken at the different points in time.

14. The non-transitory computer readable medium of claim 12 ,

wherein the plurality of display images comprises display images based upon extracted volumetric data representative of a plurality of different sub-pleural regions of the anatomical structure of interest.

15. The non-transitory computer readable medium of claim 12 ,

wherein the plurality of display images comprises display images rendered at a plurality of viewing directions from the set of volumetric data.

16. A system, for visualizing sub-pleural regions of an anatomical structure, the system comprising:

a memory, the memory configured to store volumetric data; and

a processor, the processor configured to:

receive a set of volumetric data representative of an anatomical structure of interest, wherein the anatomical structure of interest comprises an outer surface and a plurality of sub-pleural regions, each of the plurality of sub-pleural regions being a region of the anatomical structure of interest which is distant from the outer surface by a corresponding sub-pleural depth and wherein the volumetric data representative of the anatomical structure of interest comprises volumetric data representative of the outer surface and volumetric data representative of each of the plurality of sub-pleural regions;

determine a first subpleural depth;

determine a first sub-pleural region of the plurality of sub-pleural regions of the anatomical structure of interest, the first sub-pleural region being distant from the outer surface of the anatomical structure of interest by the first sub-pleural depth;

based on the determined first sub-pleural region, extract, from the set of volumetric data, the volumetric data representative of the first sub-pleural region; and

render a display image based upon the extracted volumetric data representative of the first sub-pleural region.

17. The system of claim 16 , wherein rendering the display image further comprises projecting the volumetric data representative of the first sub-pleural region onto the display image.

18. The system of claim 16 , wherein the anatomical structure of interest comprises at least one lung.

19. The system of claim 18 , wherein the outer surface comprises at least one of a lung pleurae or a visceral pleura.

20. The system of claim 16 , wherein each of the plurality of sub-pleural regions is a region which is offset from the surface of the anatomical structure of interest by the corresponding sub-pleural depth in an offset direction normal to the surface of the anatomical structure based on a three-dimensional model of the anatomical structure of interest.

Assignments (5)

Continuity (2)

References Cited (122)