Acellular soft tissue-derived matrices and methods for using same
Methods are provided for treatment of several conditions of one or more body features, where the method comprises implanting an acellular soft tissue-derived matrix in, on, proximate to, or a combination thereof, the body feature, wherein the acellular soft tissue-derived matrix comprises a delipidated, decellularized adipose matrix. The delipidated, decellularized adipose tissue matrix is produced by delipidating an adipose tissue sample, followed by decellularizing the delipidated adipose tissue sample. The resulting matrix contains a proportion of lipids which is less than the proportion of lipids contained in a matrix produced by decellularizing an adipose tissue sample prior to delipidating. The delipidated, decellularized adipose matrix may be provided as particles, a slurry, a paste, a gel, an injectable form, or in some other form.
1. A method for treatment of a condition of a body feature, the method comprising implanting an acellular soft tissue-derived matrix in, on, proximate to, or a combination thereof, the body feature, wherein the acellular soft tissue-derived matrix comprises a delipidated, decellularized adipose tissue matrix derived from a first sample of adipose tissue which has been delipidated prior to decellularizing, wherein the delipidated, decellularized adipose tissue matrix contains a first proportion of lipids which is less than a second proportion of lipids contained in a processed adipose tissue derived from a second sample of adipose tissue which has been decellularized prior to delipidating.
2. The method of claim 1 , wherein the treatment comprises one or more of:
volume restoration or replacement,
volume augmentation,
increasing, enhancing, or improving volume retention,
deficit management,
cushioning or padding areas where tissue is missing or has been removed;
healing, repair or reconstruction of a wound,
providing a stimulus to host tissue,
reconstructing or reshaping at least a portion of a body feature,
reduction or elimination of undesirable defects or attributes, and
restoration of damaged or atrophied tissue.
3. The method of claim 2 , wherein the treatment is selected from: filling, cushioning, padding, reshaping, or augmenting a facial defect or attribute, rejuvenating a facial defect or attribute, and repairing or regenerating tissue of a facial defect or attribute.
4. The method of claim 3 , wherein the treatment is selected from: rejuvenation of facial skin, a lip, an eyelid, a cheek, a chin, or a temple; reshaping or recontouring a lip, a check, a temple, a jawline, or a temple; reducing or eliminating wrinkles, nasolabial folds, a dimple, a dip, a divot, a scar, or a combination thereof; augmentation of a lip, a cheek, a chin, or a temple; craniofacial repair or reconstruction.
5. The method of claim 2 , wherein the treatment is selected from: face volumization, hand volumization, fat pad volumization, temple volumization, breast volumization, and volumization of an atrophied, diseased, or cosmetically undesirable body feature.
6. The method of claim 2 , wherein the treatment is breast reconstruction, breast reshaping, breast augmentation, or a combination thereof.
7. The method of claim 1 , wherein the condition comprises one or more of:
atrophy,
diseased tissue,
a congenital defect,
weak or strained body feature,
a tunneling wound,
a chronic or acute wound,
a void, cavity, space, or pocket in a tissue or body feature resulting from disease, trauma or a therapeutic treatment,
lipoatrophy,
age-related defects or attributes,
and aesthetically undesirable attributes.
8. The method of claim 7 , wherein the condition is one or more of: fat pad atrophy; temple atrophy, cheek atrophy, a void, pocket or other defect in a breast created during a surgical procedure, cleft lip, cleft palate, cleft chin, HIV lipoatrophy, radiation fibrosis syndrome, a superficial burn, wrinkles, a dimple, a dip, a divet, drooping eyelid, nasolabial folds, jowls, insufficiently cushioned bony prominence, asymmetry, weakened or strained vocal chords, and other undesirable attributes.
9. The method of claim 1 , wherein the body feature is one or more of: a face or portion thereof, a craniofacial feature, an extremity, a joint, a buttock, a torso or portion thereof, a back or portion thereof, dermis, muscle, and nerve.
10. The method of claim 9 , wherein the body feature is one or more of: a mouth, a forehead, a cheek, a chin, pre-jowls, a temple, an eyelid, a nose, an arm, a shoulder, a wrist, a hand, a finger, a chest, a breast, an abdomen, a leg, a hip, a knee, a calf, a shin, a foot, a toe, a joint, a fat pad, dermis, a muscle, a nerve, a blood vessel, a bone, a tendon, a ligament, a heart, and a lung.
11. The method of claim 1 , wherein the delipidated, decellularized adipose tissue matrix has a particulate form, an injectable form, or a combination thereof.
12. The method of claim 1 , wherein the delipidated, decellularized adipose tissue matrix is dehydrated, partially dehydrated, or not dehydrated.
13. The method of claim 1 , wherein the delipidated, decellularized adipose tissue matrix is a component of an implant and the method comprises implanting the implant.
14. The method of claim 13 , wherein the implant is a particulate form, an injectable form, or a combination thereof.
15. The method of claim 13 , wherein the implant is dehydrated, partially dehydrated, or not dehydrated.
16. The method of claim 13 , wherein the implant further comprises a carrier.
17. The method of claim 13 , wherein the implant is a slurry, paste or gel.
18. The method of claim 13 , wherein the implant further comprises tissuegenic cells exogenous to the first sample of adipose tissue, growth factors exogenous to the first sample of adipose tissue, or a combination thereof.
19. The method of claim 1 , wherein the treatment comprises at least one of a cosmetic surgical procedure and a reconstructive surgical procedure.