IP Library Granted Patent US 12,564,678
Granted Patent B2
US 12,564,678 · App. 17/537,660 · Granted Mar 3, 2026

Systems and methods for optimizing medicament dosing

Inventors: Yuxiang Zhong (Arcadia, CA); Anirban Roy (Agoura Hills, CA); Pratik J. Agrawal (Porter Ranch, CA); Ali Dianaty (Porter Ranch, CA); Arthur Mikhno (Princeton, NJ); Shruti Rastogi (Northridge, CA); Taly G. Engel (Los Angeles, CA); Michael P. Stone (Long Beach, CA); Boyi Jiang (Pasadena, CA); Sinu Bessy Abraham (Gallatin, TN); Dae Y. Kang (Los Angeles, CA)
Assignee: MEDTRONIC MINIMED, INC.
A61M5/1723A61M5/16877A61M2205/3327A61M2205/50A61M2205/502A61M2230/201A61M2230/63
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Quick Facts
Patent No.
US 12,564,678
App. No.
17/537,660
Granted
Mar 3, 2026
Kind
B2
Abstract

A system for monitoring a patient, wherein the system includes one or more processors and a sensor device implemented in circuitry. The system is configured to measure, using the sensor device, a blood glucose status of the patient, and determine, using the one or more processors, an initial insulin dose for the patient based on the blood glucose status of the patient. The system is further configured to optimize the initial insulin dose for the patient, based at least in part on a correction factor, to create an optimized insulin dose for the patient. The system is configured to facilitate therapy, using the one or more processors, based on the optimized insulin dose.

Claims (34)

1 . A system for monitoring a patient to optimize medicament dosing, the system comprising one or more processors and a patient device implemented in circuitry, the system being configured to:

receive, using the patient device, an input, the input being indicative of a blood glucose status of the patient;

determine, using the one or more processors, an initial insulin dose for the patient based on the input;

optimize, using the one or more processors, the initial insulin dose for the patient, based at least in part on a correction factor received by the one or more processors to create an optimized insulin dose for the patient, wherein the correction factor is determined based at least in part on a rate of change of a glucose level of the patient that is bounded using stored historical compensation data of the patient; and

facilitate therapy, using the one or more processors, based on the optimized insulin dose.

2 . The system of claim 1 , wherein the input comprises a patient input to the patient device.

3 . The system of claim 2 , wherein the patient input comprises a gesture recognized by a gesture recognition program resident on at least one of the one or more processors and the circuitry of the patient device.

4 . The system of claim 2 , wherein the patient input comprises an indication of at least one of a type and an amount of food or beverage consumed by the patient.

5 . The system of claim 1 , wherein the input comprises a target blood glucose level for the patient.

6 . The system of claim 1 , further comprising a sensor device implemented in circuitry in communication with the patient device and wherein the input comprises the blood glucose status of the patient.

7 . The system of claim 6 , wherein the blood glucose status comprises a continuous rate of change of the glucose level of the patient as measured by the sensor device.

8 . The system of claim 6 , wherein the blood glucose status comprises a glucose measurement of the patient as measured by the sensor device.

9 . The system of claim 1 , further comprising:

an insulin pump in communication with the one or more processors; and

an infusion set coupled to the insulin pump through tubing, wherein the insulin pump is configured to provide the optimized insulin dose to the patient using the infusion set.

10 . The system of claim 1 , further comprising an injection device in communication with the one or more processors, wherein the injection device is configured to provide the optimized insulin dose to the patient.

11 . A system for monitoring a patient to optimize medicament dosing, the system comprising one or more processors and a sensor device implemented in circuitry, the system being configured to:

measure, using the sensor device, a blood glucose status of the patient;

determine, using the one or more processors, an initial insulin dose for the patient based on the blood glucose status of the patient;

optimize, using the one or more processors, the initial insulin dose for the patient, based at least in part on a correction factor received by the one or more processors to create an optimized insulin dose for the patient, wherein the correction factor is determined based at least in part on a rate of change of a glucose level of the patient that is bounded using stored historical compensation data of the patient; and

facilitate therapy, using the one or more processors, based on the optimized insulin dose.

12 . The system of claim 11 , wherein the correction factor comprises a patient input received from a patient device in communication with the one or more processors.

13 . The system of claim 12 , wherein the patient input comprises an indication of at least one of a type and an amount of food or beverage consumed by the patient as detected by the patient device.

14 . The system of claim 12 , wherein the patient input comprises an indication of at least one of a type and a duration of exercise performed by the patient as detected by the patient device.

15 . The system of claim 11 , wherein the correction factor comprises a gesture recognized by a gesture recognition program resident on at least one of the one or more processors.

16 . The system of claim 11 , wherein the correction factor comprises a target blood glucose level for the patient.

17 . The system of claim 11 , wherein the blood glucose status comprises a glucose measurement of the patient as measured by the sensor device.

18 . The system of claim 11 , wherein the blood glucose status comprises a continuous rate of change of the glucose level of the patient as measured by the sensor device.

19 . A method for monitoring a patient to optimize medicament dosing, the method comprising:

measuring, using a sensor device implemented in circuitry, a blood glucose status of the patient;

determining, using one or more processors, an initial insulin dose for the patient based on the blood glucose status of the patient;

optimizing, using the one or more processors, the initial insulin dose for the patient, based at least in part on a correction factor received by the one or more processors to create an optimized insulin dose for the patient, wherein the correction factor is determined based at least in part on a rate of change of a glucose level of the patient that is bounded using stored historical compensation data of the patient; and

facilitating therapy, using the one or more processors, based on the optimized insulin dose.

20 . The method of claim 19 , wherein the blood glucose status comprises a continuous rate of change of the glucose level of the patient as measured by the sensor device.

Assignments (2)
SECURITY INTEREST Recorded Jan 16, 2026
From: MEDTRONIC MINIMED, INC.; COMPANION MEDICAL, INC.
To: CITIBANK, N.A.
Reel/Frame 074394/0237 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 30, 2021
From: ZHONG, YUXIANG; ROY, ANIRBAN; AGRAWAL, PRATIK J.; DIANATY, ALI; MIKHNO, ARTHUR; RASTOGI, SHRUTI; ENGEL, TALY G.; STONE, MICHAEL P.; JIANG, BOYI; ABRAHAM, SINU BESSY; KANG, DAE Y.
To: MEDTRONIC MINIMED, INC.
Reel/Frame 058238/0800 →