Parenteral formulations

1. A method of preparing an aqueous parenteral formulation comprising:

(i) 0.3 mg/mL to 50 mg/mL of cannabinoids comprising cannabichromene (CBC), cannabichromenic acid (CBCV), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabigerol (CBG), cannabigerol propyl variant (CBGV), cannabicyclol (CBL), cannabinol (CBN), cannabinol propyl variant (CBNV), cannabitriol (CBO), tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), tetrahydrocannabivarinic acid (THCVA), or a combination thereof;

(ii) 5 mg/mL to 50 mg/mL of an isotonic agent comprising glucose, polyethylene glycol, or glycerol;

(iii) 0.1 mg/mL to 10 mg/mL of one or more stability enhancers comprising ascorbic acid, monothioglycerol, cysteine HCl, glutathione, disodium EDTA, calcium disodium EDTA, or a combination thereof; and

(iv) 5 mg/mL to about 500 mg/mL of a non-ionic surfactant comprising polyoxyethylene (20) sorbitan monooleate, macrogol 15hydroxystearate, or polyoxamers

wherein the aqueous parenteral formulation has an osmolality of from 100-500 mOsMol/Kg; and

wherein the aqueous parenteral formulation has a shelf-life of at least about 12 months;

the method comprising:

preparing a stock solution of the cannabinoid and the non-ionic surfactant;

preparing an aqueous solution comprising the isotonic agent and the one or more stability enhancers; and

adding the aqueous solution to the stock solution of the cannabinoid and the non-ionic surfactant.

2. The method of claim 1 , wherein the cannabinoid comprises cannabidiol (CBD), cannabidivarin (CBDV), tetrahydrocannabinol (THC), or a combination thereof.

3. The method of claim 1 , wherein the cannabinoid comprises CBD or CBDV.

4. The method of claim 1 , the cannabinoid is present in an amount ranging from about 0.5 mg/mL to about 20 mg/mL.

5. The method of claim 1 , wherein the isotonic agent is present in an amount ranging from about 10 mg/mL to about 30 mg/mL.

6. The method of claim 1 , wherein the one or more stability enhancers comprise ascorbic acid, monothioglycerol, calcium disodium EDTA, or a combination thereof.

7. The method of claim 1 , wherein the one or more stability enhancers is present in an amount ranging from 0.5 mg/mL to 10 mg/mL.

8. The method of claim 1 , wherein the cannabinoid comprises CBD or CBDV; the non-ionic surfactant comprises macrogol 15 hydroxystearate; the isotonic agent comprises glycerol; and the one or more stability enhancers comprise ascorbic acid, monothioglycerol, calcium disodium EDTA, or a combination thereof.

9. The method of claim 1 , further comprising:

heating the non-ionic surfactant;

heating the cannabinoid; and then

adding the heated cannabinoid to the heated non-ionic surfactant to form the stock solution of the cannabinoid and the non-ionic surfactant.

10. The method of claim 9 , further comprising:

preparing an aqueous solution comprising the one or more stability enhancers; and

combining the aqueous solution with the stock solution of the cannabinoid and the non-ionic surfactant.

11. The method of claim 1 , wherein the cannabinoid comprises CBD or CBDV, the non-ionic surfactant comprises macrogol 15 hydroxystearate, the isotonic agent comprises glycerol, and the one or more stability enhancers comprise ascorbic acid, monothioglycerol, or calcium disodium EDTA, or a combination thereof; and the method further comprises:

generating a solution of CBD or CBDV in macrogol 15 hydroxystearate by

heating the macrogol 15 hydroxystearate to about 40° C.; and

adding the CBD or CBDV at about 60° C. to the macrogol 15 hydroxystearate;

generating an aqueous solution by

sparging water with nitrogen;

heating the water to about 60° C.; and

adding the glycerol, monothioglycerol, EDTA and ascorbic acid to the heated water; and

adding to the solution of CBD or CBDV in Macrogol 15 hydroxystearate to the aqueous solution.

12. The method of claim 1 , wherein the aqueous parenteral formulation is sterilized by filtration.

13. The method of claim 12 , wherein the aqueous parenteral formulation is aseptically filled into a vial, ampule, syringe, or infusion bag.