Compositions for therapy and health containing amino acids with bitter taste

1. A dry blended preparation comprising at least three amino acids entities and an excipient formulation, wherein the dry blended preparation is suitable for oral administration, wherein at least one amino acid entity has a bitter taste and the dry blended preparation has an acceptable taste, wherein the excipient formulation has fewer than eleven (11) ingredients, wherein the amino acid entities are not part of a peptide longer than 20 amino acids long, wherein the bitter tasting amino acid is arginine, valine, leucine, isoleucine, tryptophan, or phenylalanine; and one or both of:

the excipient formulation comprises acesulfame, and acesulfame is present in the dry blended preparation at a level less than 1% (w/w); or

the excipient formulation comprises sucralose, and sucralose is present in the dry blended preparation at a level less than 1.0% (w/w).

2. The dry blended preparation of claim 1 , wherein sucralose is present in the dry blended preparation at a level less than 0.5% (w/w).

3. The dry blended preparation of claim 2 , wherein sucralose is present in the dry blended preparation at a level less than 0.3% (w/w).

4. The dry blended preparation of claim 3 , wherein sucralose is present in the dry blended preparation at a level less than 0.25% (w/w).

5. The dry blended preparation of claim 1 , wherein the bitter tasting amino acid entity is arginine.

6. The dry blended preparation of claim 5 , wherein the arginine is arginine-HCl.

7. The dry blended preparation of claim 1 , wherein the amino acid entity comprises amino acids selected from the groups consisting of:

(i) leucine, isoleucine, valine, lysine, histidine, threonine, and L-ornithine-L-aspartate;

(ii) leucine, isoleucine, valine, acetylcysteine (NAC), and acetyl-L-carnitine (ALCAR);

(iii) leucine, isoleucine, valine, arginine, histidine, and phenylanine; and

(iv) leucine, isoleucine, valine, and arginine.

8. The dry blended preparation of claim 1 , which: i) is free of lecithin, ii) free of a bitterness masking agent, or iii) free of a rapid onset sweetener.

9. The dry blended preparation of claim 1 , wherein the excipient formulation comprises Xanthan Gum.

10. The dry blended preparation of claim 1 , wherein the excipient formulation comprises a pH modifying agent comprising citric acid.

11. The dry blended preparation of claim 1 , wherein the excipient formulation comprises a single flavor agent comprising an orange citrus flavor.

12. The dry blended preparation of claim 1 , wherein the excipient formulation comprises a vanilla custard flavor agent.

13. The dry blended preparation of claim 1 , wherein the excipient formulation comprises an orange coloring agent.

14. The dry blended preparation of claim 1 , wherein the excipient formulation comprises a sweetener, a thickening agent, a pH modifying agent, a single flavor agent, an aroma flavor agent, and a coloring agent.

15. The dry blended preparation of claim 1 , wherein the excipient formulation consists of a sweetener, a thickening agent, a pH modifying agent, a single flavor agent, an aroma flavor agent, and a coloring agent.

16. The dry blended preparation of claim 14 , wherein the sweetener is sucralose, wherein the thickening agent is Xanthan Gum, the pH modifying agent is citric acid, the flavor agent is an orange citrus flavor, the aroma flavor agent is vanilla custard, and the coloring agent is orange.

17. The dry blended preparation of claim 1 , wherein the excipient formulation comprises sucralose, Xanthan Gum, citric acid for modifying pH, an orange citrus flavor agent, a vanilla custard aroma flavor agent, and an orange coloring agent.

18. The dry blended preparation of claim 1 , wherein the excipient formulation consists of sucralose, Xanthan Gum, citric acid for modifying pH, an orange citrus flavor agent, a vanilla custard aroma flavor agent, and an orange coloring agent.

19. The dry blended preparation of claim 14 , which is: i) free of lecithin, ii) free of a bitterness masking agent, or iii) free of a rapid onset sweetener.

20. The dry blended preparation of claim 1 , wherein the excipient formulation is less than about 30% of the dry blended preparation by weight.

21. The dry blended preparation of claim 1 , which comprises at least four amino acid entities.

22. The dry blended preparation of claim 1 , wherein the pH of the dry blended preparation when dissolved in water is less than or equal to.

23. The dry blended preparation of claim 1 , wherein the excipient formulation has fewer than ten (10), nine (9), eight (8), seven (7), six (6), or five (5) ingredients.

24. The dry blended preparation of claim 1 , wherein the taste of the dry blended preparation is less bitter than the taste of the at least one amino acid entity having a bitter taste.

25. The dry blended preparation of claim 1 , wherein the dry blended preparation comprises less than or equal to 1% water by weight (w/w).

26. The dry blended preparation of claim 1 , wherein the excipient formulation comprises acesulfame, and acesulfame is present in the composition at a level less than 1% (w/w).

27. The dry blended preparation of claim 1 , wherein the excipient formulation comprises sucralose, and sucralose is present in the composition at a level less than 1.0% (w/w).

28. The dry blended preparation of claim 1 , wherein: the excipient formulation comprises acesulfame, and acesulfame is present in the composition at a level less than 1% (w/w); and the excipient formulation comprises sucralose, and sucralose is present in the composition at a level less than 1.0% (w/w).

29. The dry blended preparation of claim 28 , wherein the excipient formulation is less than about 20% of the dry blended composition by weight.

30. The dry blended preparation of claim 1 , wherein the dry blended preparation is formulated into a unit dosage of between about 4 g and about 80 g total amino acids.

31. The dry blended preparation of claim 22 , wherein the pH of the dry blended preparation when dissolved in water is from 3 to 4.6.

32. The dry blended preparation of claim 22 , wherein the pH of the dry blended preparation when dissolved in water is from 3.5 to 6.

33. The dry blended preparation of claim 22 , wherein the pH of the dry blended preparation when dissolved in water is from 3 to 5.