TONGKAT ALI EXTRACT PRODUCTION PROCESSES AND USES THEREOF
Methods for isolating bioactive components from Eurycoma longifolia (Tongkat Ali) are described. In one aspect, the methods comprise concentrating a solution comprising Eurycoma longifolia extract by a continuous-flow evaporation process. Extracts of Eurycoma longifolia and compositions comprising Eurycoma longifolia extract and uses thereof are also provided. The extracts and the compositions are useful for increasing testosterone levels and supporting natural stamina, endurance and strength.
1 - 23 . (canceled)
24 . A composition comprising 10% eurycomanone by weight.
25 . The composition of claim 24 , which is formulated for oral administration.
26 . The composition of claim 25 , wherein the composition is a component of a capsule, tablet, powder, or sachet dosage form.
27 . A method of making a eurycomanone composition, comprising:
preparing an extract of Eurycoma longifolia comprising eurycomanone in a first solvent;
concentrating the extract;
separating impurities from the eurycomanone in the extract;
purifying the extract in a second solvent; and
drying the extract to produce a powder;
wherein the powder contains at least 5% eurycomanone by weight.
28 . The method of claim 27 , wherein the first solvent comprises about 70% ethanol by volume.
29 . The method of claim 27 , wherein the Eurycoma longifolia is extracted at about 70° C. to about 75° C. for about 1.5 to about 2 hours.
30 . The method of claim 27 , wherein the first solvent comprises about 90% ethanol by volume.
31 . The method of claim 30 , wherein the Eurycoma longifolia is extracted at about 80° C. to about 90° C. for about 3.5 to about 5 hours.
32 . The method of claim 27 , wherein the Eurycoma longifolia is extracted three times.
33 . The method of claim 27 , wherein the extract is concentrated by continuous flow evaporation.
34 . The method of claim 33 , wherein the extract is concentrated at about 70° C. to about 75° C. for about 6 hours.
35 . The method of claim 33 , wherein the extract is concentrated at about 70° C. to about 85° C. for about 10 hours.
36 . The method of claim 27 , wherein the impurities are separated from the eurycomanone by column chromatography.
37 . The method of claim 27 , wherein the second solvent comprises about 70% ethanol by weight.
38 . The method of claim 37 , wherein the extract is purified at about 70° C. to about 75° C. for about 8 hours.
39 . The method of claim 27 , wherein the second solvent comprises about 60% ethanol by weight.
40 . The method of claim 39 , wherein the extract is purified at about 60° C. to about 65° C. for about 20 hours.
41 . The method of claim 27 , wherein the extract is dried by spray drying.
42 . The method of claim 27 , wherein the powder comprises at least 10% eurycomanone by weight.
43 . The method of claim 27 , further comprising, after drying, formulating the composition in a capsule, tablet, powder, or sachet for oral administration.
44 . A method of making a eurycomanone composition, comprising:
I. extracting Eurycoma longifolia by heating in a solution of 70% ethanol by volume at 70° C. to 80° C. for about 1.5 to 2 hours;
II. concentrating the resulting extract by continuous flow evaporation at 70° C. to 75° C. for about 6 hours;
III. separating impurities from the concentrated extract by column chromatography;
IV. purifying the extract by heating in a solution of 70% ethanol by weight at 70° C. to 75° C. for about 8 hours; and
V. spray drying the purified extract to produce a powder; wherein:
the Eurycoma longifolia comprises eurycomanone; and
the powder contains at least 10% eurycomanone by weight.
45 . The method of claim 44 , wherein step I is repeated three times prior to concentrating in step II.
46 . The method of claim 45 further comprising, after step V, formulating the composition in a capsule, tablet, powder, or sachet for oral administration.