RAPID DELIVERY AND/OR WITHDRAWAL OF FLUIDS
The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.
1 - 148 . (canceled)
149 . A device for withdrawing blood from the skin and/or from beneath the skin of a subject, the device comprising:
an actuator;
a flexible concave member, wherein the flexible concave member is moveable between a first configuration and a second configuration upon actuation of the actuator;
a needle, wherein the needle is in a first position before actuation of the actuator and in a second position after actuation of the actuator,
wherein the actuator is able to move the needle from the first position to the second position at a speed of at least 1 cm/s.
150 . The device of claim 149 , wherein the actuator is able to move the needle from the first position to the second position at a speed of at least 10 cm/s.
151 . The device of claim 149 , wherein the actuator is able to move the needle from the first position to the second position at a speed of an acceleration of at least 100,000 meters/second 2 .
152 . The device of claim 149 , wherein the first position and the second position of the needle are separated by a distance of no more than 5 mm.
153 . The device of claim 149 , wherein the actuator is able to move the needle from the first position to the second position in a period of time of less than 0.002 seconds.
154 . The device of claim 149 , wherein the actuator is able to move the needle from the first position to the second position with a force sufficient to insert the needle into the skin to a depth of at least 60% of the length of the needle.
155 . The device of claim 149 , wherein the needle is a microneedle.
156 . The device of claim 149 , wherein the device is configured such that movement of the flexible concave member from the first configuration to the second configuration inserts the needle into the subject's skin.
157 . The device of claim 149 , wherein the device is configured such that movement of the flexible concave member from the first configuration to the second configuration and moves the needle from the first position to the second position.
158 . The device of claim 149 , wherein the device further comprises a retraction mechanism able to move the needle towards the first position after the needle reaches the second position.
159 . A device for withdrawing blood from the skin and/or from beneath the skin of a subject, the device comprising:
an actuator;
a flexible concave member, wherein the flexible concave member is moveable between a first configuration and a second configuration upon actuation of the actuator;
a needle, wherein the needle is in a first position before actuation of the actuator and in a second position after actuation of the actuator,
wherein the actuator is able to move the needle from the first position to the second position at an acceleration of at least 100,000 meters/second.
160 . The device of claim 159 , wherein the actuator is able to move the needle from the first position to the second position at a speed of at least 1 cm/s.
161 . The device of claim 159 , wherein the actuator is able to move the needle from the first position to the second position at a speed of at least 10 cm/s.
162 . The device of claim 159 , wherein the first position and the second position of the needle are separated by a distance of no more than 5 mm.
163 . The device of claim 159 , wherein the actuator is able to move the needle from the first position to the second position in a period of time of less than 0.002 seconds.
164 . The device of claim 159 , wherein the actuator is able to move the needle from the first position to the second position with a force sufficient to insert the needle into the skin to a depth of at least 60% of the length of the needle.
165 . The device of claim 159 , wherein the needle is a microneedle.
166 . The device of claim 159 , wherein the device is configured such that movement of the flexible concave member from the first configuration to the second configuration inserts the needle into the subject's skin.
167 . The device of claim 159 , wherein the device is configured such that movement of the flexible concave member from the first configuration to the second configuration and moves the needle from the first position to the second position.
168 . The device of claim 159 , wherein the device further comprises a retraction mechanism able to move the needle towards the first position after the needle reaches the second position.