IP Library Granted Patent US 12,594,091
Granted Patent B2
US 12,594,091 · App. 17/571,101 · Granted Apr 7, 2026

Ultrasonic surgical instrument with probe at angle to handpiece

Inventors: Dan Voic (Cedar Grove, NJ); Alexander Darian (Brightwaters, NY); Scott Isola (Deer Park, NY); Lawrence Agtuca (Holbrook, NY)
Assignee: Misonix, LLC
A61B17/320068A61B2017/320082
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Quick Facts
Patent No.
US 12,594,091
App. No.
17/571,101
Granted
Apr 7, 2026
Kind
B2
Abstract

An ultrasonic surgical instrument includes a handpiece casing and an electromechanical transducer assembly disposed inside the handpiece casing, where the transducer assembly includes a front driver and the transducer assembly has a longitudinal axis. A probe is operatively connected to the front driver at an acute angle to the longitudinal axis of the transducer assembly. A sheath surrounds the probe and is connected at a proximal end to the handpiece casing. The sheath is attached to the casing by a twist quick release coupling. A diaphragm seal inside the proximal end of the sheath blocks liquid irrigant in a cylindrical space between the sheath and the probe from penetrating proximally of a port feeding irrigant to the space. The front driver is geometrically configured to enable an angled connection of probe to handpiece proximate a nodal plane.

Claims (39)

1 . An ultrasonic surgical instrument comprising:

a handpiece;

an electromechanical transducer assembly disposed inside the handpiece, the transducer assembly including a front driver, the transducer assembly having a longitudinal axis;

a probe operatively connected to the front driver at an angle to the longitudinal axis, the probe having a distal end provided with an end effector;

a sheath surrounding the probe and connected at a proximal end to the handpiece, the end effector configured to extend distal to a distal tip of the sheath; and

an annular sealing member configured to engage a portion of a distal surface of the handpiece and be clamped between a proximal surface of the sheath and the distal surface of the handpiece.

2 . The ultrasonic surgical instrument defined in claim 1 , wherein the probe is connected to the front driver in close proximity to a nodal plane.

3 . The ultrasonic surgical instrument defined in claim 1 , further including:

at least two first closure elements on a distal surface of the handpiece and a corresponding number of second closure elements on the proximal end of the sheath.

4 . The ultrasonic surgical instrument defined in claim 3 , wherein the at least two first closure elements include a projection extending in a radial direction, the second closure elements each taking the form of an annular open channel having one tapered end defined by a camming surface.

5 . The ultrasonic surgical instrument defined in claim 4 , wherein the projections are annular ribs extending in a plane transverse to an axis of the sheath.

6 . The ultrasonic surgical instrument defined in claim 4 , wherein the camming surface is located along a distal side of the annular open channel and faces in a proximal direction towards the handpiece.

7 . The ultrasonic surgical instrument defined in claim 3 , wherein the annular sealing member is made of a resiliently compressible material, the at least two first closure elements and the second closure elements being configured to frictionally lock the sheath to the handpiece by compression of the annular sealing member.

8 . The ultrasonic surgical instrument defined in claim 7 , wherein the handpiece is fastened to the sheath by only one locking mechanism, the only one locking mechanism comprising the annular sealing member, the at least two first closure elements, and the second closure elements.

9 . The ultrasonic surgical instrument defined in claim 1 , wherein the annular sealing member is radially spaced from a portion of the handpiece and the probe.

10 . The ultrasonic surgical instrument defined in claim 1 , wherein the ultrasonic transducer assembly is configured to generate ultrasonic vibratory energy at a predetermined frequency that can cause reciprocating movements of the end effector,

the handpiece having a length of a quarter wavelength of the predetermined frequency and the probe having a length of three-quarter wavelengths of the predetermined frequency to facilitate the reciprocating movements of the end effector.

11 . The ultrasonic surgical instrument defined in claim 1 , wherein the probe includes an externally threaded proximal end, and the front driver includes an internally threaded receptacle at a distal end thereof and configured to receive the externally threaded proximal end of the probe, the internally threaded receptacle having a proximal end surface disposed at an angle relative to the longitudinal axis.

12 . An ultrasonic surgical instrument comprising:

a handpiece defining a longitudinal axis;

an electromechanical transducer assembly disposed inside the handpiece, the electromechanical transducer assembly including a front driver;

a probe operatively connected to the front driver at an acute angle to the longitudinal axis, the probe having a distal end provided with an end effector, the electromechanical transducer assembly configured to generate ultrasonic vibratory energy that can be delivered to the probe;

a sheath surrounding the probe and connected at a proximal end to the handpiece, the end effector extending distally of a distal tip of the sheath, the sheath being provided proximate the proximal end with a port connectable to a source of pressurized liquid coolant for flowing the pressurized liquid coolant into a tubular space between the probe and an inner surface of the sheath;

a diaphragm seal disposed near the proximal end of the sheath, the diaphragm seal having an annular outer surface that contacts and forms a liquid-tight seal with the inner surface of the sheath and an annular inwardly extending flange that contacts and forms a liquid-tight seal with the probe, the diaphragm seal configured to reduce sensations experienced by a user grasping a proximal portion of the sheath when the ultrasonic transducer assembly is generating the ultrasonic vibratory energy.

13 . The ultrasonic surgical instrument defined in claim 12 , wherein the diaphragm is provided at a proximal end with an annular sealing member clamped between a proximal end surface of the sheath and a distal end surface of the handpiece.

14 . The ultrasonic surgical instrument defined in claim 12 , wherein the diaphragm is spaced from the probe except at the annular inwardly extending flange.

15 . The ultrasonic surgical instrument defined in claim 12 , wherein the sheath has a main body at a proximal end made of rigid material, the sheath further comprising a distal end portion made of silicone polymer.

16 . The ultrasonic surgical instrument defined in claim 12 , wherein the front driver has two mutually parallel planar outer surfaces extending parallel to the longitudinal axis of the transducer assembly, each of the two mutually parallel planar outer surfaces being contiguous with a first cylindrical outer surface and a second cylindrical outer surface.

17 . The ultrasonic surgical instrument defined in claim 12 , wherein the handpiece is formed at a distal end with a cylindrical first internal surface coaxial with the longitudinal axis of the transducer assembly and further formed with a cylindrical second internal surface coaxial with the longitudinal axis of the probe.

18 . The ultrasonic surgical instrument defined in claim 12 , wherein the probe is connected to the front driver in close proximity to a nodal plane.

19 . The ultrasonic surgical instrument defined in claim 12 , wherein the ultrasonic transducer assembly is configured to generate ultrasonic vibratory energy at a predetermined frequency that can cause reciprocating movements of the end effector,

the handpiece having a length of a quarter wavelength of the predetermined frequency and the probe having a length of three-quarter wavelengths of the predetermined frequency to facilitate the reciprocating movements of the end effector.

20 . The ultrasonic surgical instrument defined in claim 12 , wherein the probe includes an externally threaded proximal end, and the front driver includes an internally threaded receptacle at a distal end thereof and configured to receive the externally threaded proximal end of the probe, the internally threaded receptacle having a proximal end surface disposed at an angle relative to the longitudinal axis.

21 . An apparatus, comprising:

a handpiece defining a longitudinal axis;

a sheath coupled to a distal end of the handpiece, the sheath defining a lumen;

a probe disposed within the lumen, the probe and the sheath extending from the distal end of the handpiece at an angle relative to the longitudinal axis, the probe including an end effector that is configured to be disposed distal to the sheath when the probe is disposed in the lumen; and

an ultrasonic transducer assembly disposed within the handpiece and coupled to the probe, the ultrasonic transducer assembly configured to generate ultrasonic vibratory energy at a predetermined frequency that can cause reciprocating movements of the end effector,

the handpiece having a length of a quarter wavelength of the predetermined frequency and the probe having a length of three-quarter wavelengths of the predetermined frequency to facilitate the reciprocating movements of the end effector.

Assignments (3)
SECURITY INTEREST Recorded Aug 1, 2025
From: MISONIX, LLC
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 072298/0866 →
MERGER AND CHANGE OF NAME Recorded Apr 22, 2024
From: MISONIX, INC.; OYSTER MERGER SUB II, LLC
To: MISONIX, LLC
Reel/Frame 067185/0495 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 20, 2022
From: VOIC, DAN; DARIAN, ALEXANDER; ISOLA, SCOTT; AGTUCA, LAWRENCE
To: MISONIX INCORPORATED
Reel/Frame 058705/0126 →
Continuity (2)
Provisional Application 63296073 · Jan 3, 2022
Related Publication 20230210549A1 · Jul 6, 2023
References Cited (240)
US 2349959A · Edward · 1944 [cited by applicant]
US 2753666A · Sasse · 1956 [cited by applicant]
US 3368280A · Friedman et al. · 1968 [cited by applicant]
US 3680610A · Lindgren · 1972 [cited by applicant]
US 3805787A · Banko · 1974 [cited by applicant]
US 4188952A · Loschilov et al. · 1980 [cited by applicant]
US 4425115A · Wuchinich · 1984 [cited by applicant]
US 4804364A · Dieras et al. · 1989 [cited by applicant]
US 4988334A · Hornlein et al. · 1991 [cited by applicant]
US 5163433A · Kagawa et al. · 1992 [cited by applicant]
US 5176677A · Wuchinich · 1993 [cited by applicant]
US 5180363A · Idemoto et al. · 1993 [cited by applicant]
US 5222937A · Kagawa · 1993 [cited by applicant]
US 5261922A · Hood · 1993 [cited by applicant]
US 5312329A · Beaty et al. · 1994 [cited by applicant]
US 5342380A · Hood · 1994 [cited by applicant]
US 5465468A · Manna · 1995 [cited by applicant]
US 5484398A · Stoddard · 1996 [cited by applicant]
US 5517889A · Logan · 1996 [cited by applicant]
US 5527273A · Manna et al. · 1996 [cited by applicant]
US 5531597A · Foulkes et al. · 1996 [cited by applicant]
US 5695510A · Hood · 1997 [cited by applicant]
US 5769211A · Manna et al. · 1998 [cited by applicant]
US 5906595A · Powell et al. · 1999 [cited by applicant]
US 5935142A · Hood · 1999 [cited by applicant]
US 5935143A · Hood · 1999 [cited by applicant]
US 5976105A · Marcove et al. · 1999 [cited by applicant]
US 6033375A · Brumbach · 2000 [cited by applicant]
US 6036667A · Manna et al. · 2000 [cited by applicant]
US 6256859B1 · Stoddard et al. · 2001 [cited by applicant]
US 6270471B1 · Hechel et al. · 2001 [cited by applicant]
US 6352532B1 · Kramer et al. · 2002 [cited by applicant]
US 6375648B1 · Edelman et al. · 2002 [cited by applicant]
US 6379371B1 · Novak et al. · 2002 [cited by applicant]
US 6436114B1 · Novak et al. · 2002 [cited by applicant]
US 6443969B1 · Novak et al. · 2002 [cited by applicant]
US 6454730B1 · Hechel et al. · 2002 [cited by applicant]
US 6461314B1 · Pant et al. · 2002 [cited by applicant]
US 6492762B1 · Pant et al. · 2002 [cited by applicant]
US 6494714B1 · Copeland · 2002 [cited by applicant]
US 6582440B1 · Brumbach · 2003 [cited by applicant]
US 6602248B1 · Sharps et al. · 2003 [cited by applicant]
US 6613056B1 · Brumbach et al. · 2003 [cited by applicant]
US 6648839B2 · Manna et al. · 2003 [cited by applicant]
US 6736814B2 · Manna et al. · 2004 [cited by applicant]
US 6787974B2 · Fjield et al. · 2004 [cited by applicant]
US 6799729B1 · Voic · 2004 [cited by applicant]
US 6869439B2 · White et al. · 2005 [cited by applicant]
US 6902536B2 · Manna et al. · 2005 [cited by applicant]
US 7025735B2 · Soring et al. · 2006 [cited by applicant]
US 7223267B2 · Isola et al. · 2007 [cited by applicant]
US 7431704B2 · Babaev · 2008 [cited by applicant]
US 7442168B2 · Novak et al. · 2008 [cited by applicant]
US 7494488B2 · Weber · 2009 [cited by applicant]
US 7522955B2 · Rontal · 2009 [cited by applicant]
US 7608054B2 · Söring et al. · 2009 [cited by applicant]
US 7717913B2 · Novak et al. · 2010 [cited by applicant]
US 7776027B2 · Manna et al. · 2010 [cited by applicant]
US 7785278B2 · Babaev · 2010 [cited by applicant]
US D627463S · Voic et al. · 2010 [cited by applicant]
US 7905854B2 · Hazut et al. · 2011 [cited by applicant]
US 7931611B2 · Novak et al. · 2011 [cited by applicant]
US D644326S · Voic et al. · 2011 [cited by applicant]
US 8025672B2 · Novak et al. · 2011 [cited by applicant]
US 8109925B2 · Voic et al. · 2012 [cited by applicant]
US 8221424B2 · Cha · 2012 [cited by applicant]
US D667117S · Darian et al. · 2012 [cited by applicant]
US 8343178B2 · Novak et al. · 2013 [cited by applicant]
US 8348880B2 · Messerly et al. · 2013 [cited by applicant]
US 8353912B2 · Darian et al. · 2013 [cited by applicant]
US D680218S · Darian et al. · 2013 [cited by applicant]
US 8430897B2 · Novak et al. · 2013 [cited by applicant]
US 8562547B2 · Babaev · 2013 [cited by applicant]
US 8659208B1 · Rose et al. · 2014 [cited by applicant]
US 8690783B2 · Sinelnikov · 2014 [cited by applicant]
US 8698377B2 · Sinelnikov · 2014 [cited by applicant]
US 8814870B2 · Paraschiv et al. · 2014 [cited by applicant]
US 8888783B2 · Young · 2014 [cited by applicant]
US 8894673B2 · Darian · 2014 [cited by applicant]
US 8961547B2 · Dietz et al. · 2015 [cited by applicant]
US 9070856B1 · Rose et al. · 2015 [cited by applicant]
US 9211137B2 · Voic · 2015 [cited by applicant]
US 9226767B2 · Stulen et al. · 2016 [cited by applicant]
US 9320528B2 · Voic et al. · 2016 [cited by applicant]
US 9387005B2 · Voic · 2016 [cited by applicant]
US 9603656B1 · Germain et al. · 2017 [cited by applicant]
US 9622766B2 · Voic · 2017 [cited by applicant]
US 9636187B2 · Voic · 2017 [cited by applicant]
US 9693792B2 · Novak et al. · 2017 [cited by applicant]
US 9763673B2 · Young · 2017 [cited by applicant]
US 9861446B2 · Lang · 2018 [cited by applicant]
US 9872697B2 · Voic · 2018 [cited by applicant]
US 9949751B2 · Voic · 2018 [cited by applicant]
US 9962182B2 · Dietz et al. · 2018 [cited by applicant]
US 10016208B2 · Gouery et al. · 2018 [cited by applicant]
US 10076349B2 · Voic · 2018 [cited by applicant]
US 10092308B2 · Mikus et al. · 2018 [cited by applicant]
US 10092741B2 · Darian · 2018 [cited by applicant]
US 10117666B2 · Voic · 2018 [cited by applicant]
US 10182837B2 · Isola et al. · 2019 [cited by applicant]
US 10206704B2 · Voic et al. · 2019 [cited by applicant]
US 10299809B2 · Mikus et al. · 2019 [cited by applicant]
US 10398463B2 · Darian et al. · 2019 [cited by applicant]
US 10398465B2 · Darian · 2019 [cited by applicant]
US 10405875B2 · Voic et al. · 2019 [cited by applicant]
US 10463381B2 · Voic et al. · 2019 [cited by applicant]
US 10470788B2 · Sinelnikov · 2019 [cited by applicant]
US 10470789B2 · Mikus et al. · 2019 [cited by applicant]
US 10471281B2 · Mikus · 2019 [cited by applicant]
US 10543012B2 · Pantano · 2020 [cited by applicant]
US 10588691B2 · Pellegrino et al. · 2020 [cited by applicant]
US 10639733B2 · Campbell et al. · 2020 [cited by applicant]
US 10687824B2 · Shiels et al. · 2020 [cited by applicant]
US 10835276B2 · Voic et al. · 2020 [cited by applicant]
US 10842587B2 · Mikus et al. · 2020 [cited by applicant]
US 11007308B2 · Payne et al. · 2021 [cited by applicant]
US 11298434B2 · Isola et al. · 2022 [cited by applicant]
US 11317936B2 · James · 2022 [cited by examiner]
US 11324531B2 · Voic et al. · 2022 [cited by applicant]
US 11389183B2 · Voic et al. · 2022 [cited by applicant]
US 11406413B2 · Voic et al. · 2022 [cited by applicant]
US 11540853B2 · Voic et al. · 2023 [cited by applicant]
US 11672558B2 · Voic · 2023 [cited by applicant]
US 11737775B2 · Voic et al. · 2023 [cited by applicant]
US 11950790B2 · Voic · 2024 [cited by applicant]
US 12011190B2 · Theodore et al. · 2024 [cited by applicant]
US 12279787B2 · Ellegala · 2025 [cited by applicant]
US 20010029370A1 · Hodva et al. · 2001 [cited by applicant]
US 20030212395A1 · Woloszko et al. · 2003 [cited by applicant]
US 20040265776A1 · Tipton et al. · 2004 [cited by applicant]
US 20050033292A1 · Teitelbaum et al. · 2005 [cited by applicant]
US 20060030797A1 · Zhou et al. · 2006 [cited by applicant]
US 20060235305A1 · Cotter et al. · 2006 [cited by applicant]
US 20060241533A1 · Geller · 2006 [cited by applicant]
US 20070060926A1 · Escaf · 2007 [cited by applicant]
US 20070213734A1 · Bleich et al. · 2007 [cited by applicant]
US 20080015551A1 · Feine · 2008 [cited by applicant]
US 20080057470A1 · Levy et al. · 2008 [cited by applicant]
US 20080058775A1 · Darian et al. · 2008 [cited by applicant]
US 20080108985A1 · Konesky · 2008 [cited by applicant]
US 20080183173A1 · Jozat · 2008 [cited by applicant]
US 20080234709A1 · Houser · 2008 [cited by applicant]
US 20080234710A1 · Neurohr et al. · 2008 [cited by applicant]
US 20090143678A1 · Keast et al. · 2009 [cited by applicant]
US 20090247937A1 · Rontal · 2009 [cited by applicant]
US 20100022944A1 · Wilcox · 2010 [cited by applicant]
US 20100049188A1 · Nelson et al. · 2010 [cited by applicant]
US 20100076349A1 · Babaev · 2010 [cited by applicant]
US 20110092880A1 · Gertner · 2011 [cited by applicant]
US 20110105958A1 · Babaev · 2011 [cited by applicant]
US 20110160624A1 · Babaev · 2011 [cited by applicant]
US 20110264090A1 · Shadduck et al. · 2011 [cited by applicant]
US 20120014868A1 · Roy · 2012 [cited by applicant]
US 20120053492A1 · Chang et al. · 2012 [cited by applicant]
US 20130103021A1 · Germain et al. · 2013 [cited by applicant]
US 20130123774A1 · Zadeh · 2013 [cited by applicant]
US 20130209955A1 · Moran et al. · 2013 [cited by applicant]
US 20130226042A1 · Novak et al. · 2013 [cited by applicant]
US 20130231528A1 · Voic · 2013 [cited by applicant]
US 20130245638A1 · Horton et al. · 2013 [cited by applicant]
US 20140107537A1 · Beaupre · 2014 [cited by applicant]
US 20140180002A1 · Voic · 2014 [cited by applicant]
US 20140277030A1 · Lauchner · 2014 [cited by applicant]
US 20140277034A1 · Darian · 2014 [cited by applicant]
US 20140350567A1 · Schmitz et al. · 2014 [cited by applicant]
US 20140358043A1 · Akagane · 2014 [cited by applicant]
US 20150045701A1 · Akagane · 2015 [cited by applicant]
US 20150066032A1 · Young · 2015 [cited by applicant]
US 20150088137A1 · Manna · 2015 [cited by applicant]
US 20150094723A1 · Darian · 2015 [cited by applicant]
US 20150157387A1 · OuYang et al. · 2015 [cited by applicant]
US 20150164534A1 · Felder et al. · 2015 [cited by applicant]
US 20150297246A1 · Patel et al. · 2015 [cited by applicant]
US 20160022283A1 · Wallace et al. · 2016 [cited by applicant]
US 20160135835A1 · Onuma · 2016 [cited by applicant]
US 20160166276A1 · Huang et al. · 2016 [cited by applicant]
US 20160175150A1 · Banko · 2016 [cited by applicant]
US 20160206302A1 · Eckermann · 2016 [cited by applicant]
US 20160222526A1 · Rubinsky et al. · 2016 [cited by applicant]
US 20160331439A1 · Winkelman et al. · 2016 [cited by applicant]
US 20160354559A1 · Gavini et al. · 2016 [cited by applicant]
US 20170340339A1 · Madan et al. · 2017 [cited by applicant]
US 20180008138A1 · Thommen et al. · 2018 [cited by applicant]
US 20190000553A1 · Lightcap et al. · 2019 [cited by applicant]
US 20190307529A1 · Jacoby · 2019 [cited by applicant]
US 20200121374A1 · Mcgahan et al. · 2020 [cited by applicant]
US 20200178999A1 · Stabilini et al. · 2020 [cited by applicant]
US 20200205850A1 · Cao et al. · 2020 [cited by applicant]
US 20200246056A1 · Bonn · 2020 [cited by applicant]
US 20200352590A1 · Drewek · 2020 [cited by applicant]
US 20200405501A1 · Orozco Castillo · 2020 [cited by applicant]
US 20210145531A1 · Gee et al. · 2021 [cited by applicant]
US 20210228218A1 · Hauser et al. · 2021 [cited by applicant]
US 20230048993A1 · Levy et al. · 2023 [cited by applicant]
CN 101511286A · 2009 [cited by applicant]
CN 210249992U · 2020 [cited by applicant]
CN 109152577B · 2022 [cited by applicant]
EP 2745797A1 · 2014 [cited by applicant]
EP 2635192B1 · 2019 [cited by applicant]
JP H0614934A · 1994 [cited by applicant]
JP H10127682A · 1998 [cited by applicant]
JP 2019517856A · 2019 [cited by applicant]
KR 20120093654A · 2012 [cited by applicant]
WO WO2000071043A1 · 2000 [cited by applicant]
WO WO2001035812A2 · 2001 [cited by applicant]
WO WO2004060141A2 · 2004 [cited by applicant]
WO WO2007049718A1 · 2007 [cited by applicant]
WO WO2007143686A2 · 2007 [cited by applicant]
WO WO2008014258A2 · 2008 [cited by applicant]
WO WO2008017909A1 · 2008 [cited by applicant]
WO WO2008118708A2 · 2008 [cited by applicant]
WO WO2008118709A1 · 2008 [cited by applicant]
WO WO2009035508A1 · 2009 [cited by applicant]
WO WO2009098664A2 · 2009 [cited by applicant]
WO WO2009105628A2 · 2009 [cited by applicant]
WO WO2010109447A1 · 2010 [cited by applicant]
WO WO2013062118A1 · 2013 [cited by applicant]
WO WO2014024550A1 · 2014 [cited by applicant]
WO WO2014210163A1 · 2014 [cited by applicant]
WO WO2014210273A1 · 2014 [cited by applicant]
WO WO2015045198A1 · 2015 [cited by applicant]
WO WO2015046349A1 · 2015 [cited by applicant]
WO WO2015047812A1 · 2015 [cited by applicant]
WO WO2015145444A2 · 2015 [cited by applicant]
WO WO2015188735A1 · 2015 [cited by applicant]
WO WO2017180493A1 · 2017 [cited by applicant]
WO WO2017192288A1 · 2017 [cited by applicant]
WO WO2018022311A1 · 2018 [cited by applicant]
WO WO2018165004A1 · 2018 [cited by applicant]
WO WO2019095831A1 · 2019 [cited by applicant]
WO WO2019204641A1 · 2019 [cited by applicant]
WO WO2022087523A1 · 2022 [cited by applicant]
WO WO2022245499A1 · 2022 [cited by applicant]
WO WO2023018863A1 · 2023 [cited by applicant]
WO WO2023130103A1 · 2023 [cited by applicant]
International Preliminary Report on Patentability for Application No. PCT/US2023/010008, dated Jul. 18, 2024, 9 pages. [cited by applicant]
International Search Report and Written Opinion for Application No. PCT/US2023/010008, dated May 9, 2023, 12 pages. [cited by applicant]
SonicOne O.R., Ultrasonic Surgical Debridement. Brochure [online]. Misonix Ultrasonic Surgical Devices, 2012. Retrieved from the Internet: <URL: https://web.archive.org/web/20150218182717/ http://www.misonix.com:80/wp-c… [cited by applicant]
SonicOne Plus, Ultrasonic Debridement System. Brochure [online]. Misonix Ultrasonic Surgical Devices, 2013. Retrieved from the Internet: <URL: https://pdf.medicalexpo.com/pdf/misonix/sonicone-plus/79244-106567.html>, 4 … [cited by applicant]
EP Application No. 23735176.2, Extended European Search Report mailed Nov. 25, 2025; Applicant Misonix, LLC; 9 pages. [cited by applicant]