Granted Patent
B2
US 12,622,982 · App. 17/571,168 · Granted May 12, 2026
Implants and biodegradable tissue markers
Assignee:
INCEPT, LLC
A61K49/0442A61K49/0419A61K51/1244A61L27/50A61L27/52A61L27/58A61L31/145A61L31/148A61L31/18A61K2123/00
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Abstract
Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.
Claims (31)
1 . A method for radiation therapy comprising imaging margins of a hydrogel spacer using ultrasound, wherein the hydrogel spacer is at a site between a first tissue location and a second tissue location to increase a distance between the first tissue location and the second tissue location, the site being chosen to decrease radiation at the first tissue location when the second tissue location receives a dose of therapeutic radiation, wherein the hydrogel spacer comprises a polysaccharide.
2 . The method of claim 1 , wherein the polysaccharide is hyaluronic acid.
3 . The method of claim 1 , wherein the hydrogel spacer comprises an ultrasound contrast agent.
4 . The method of claim 1 , wherein the first tissue location is associated with the rectum and the second tissue location is associated with the prostate gland.
5 . The method of claim 1 , wherein the hydrogel spacer is echolucent under ultrasound imaging.
6 . The method of claim 1 , wherein the hydrogel spacer, as placed in the tissue, has a volume between 1 and 40 ml.
7 . The method of claim 1 , wherein the polysaccharide is enzymatically biodegradable.
8 . The method of claim 1 , wherein the polysaccharide is covalently-crosslinked.
9 . The method of claim 1 , wherein the polysaccharide is a glycosaminoglycan.
10 . The method of claim 9 , wherein the glycosaminoglycan is crosslinked with a reactive precursor species having electrophilic functional groups.
11 . The method of claim 1 , wherein the polysaccharide comprises esterified hyaluronic acid.
12 . The method of claim 1 , wherein the hydrogel spacer comprises hydrogel particles.
13 . The method of claim 12 , wherein the hydrogel particles comprise a collection of covalently-crosslinked, biodegradable hydrogel particles comprising the polysaccharide.
14 . The method of claim 13 , wherein the collection of particles is completely biodegradable at a time between about 30 and about 365 days.
15 . The method of claim 12 , wherein the hydrogel particles are formed by a process comprising breaking up a hydrogel polymer matrix.
16 . The method of claim 15 , wherein the hydrogel particles are formed by a process comprising forcing the hydrogel polymer matrix through a mesh.
17 . The method of claim 12 , wherein the hydrogel particles have a size range from 1 micron to 500 microns.
18 . The method of claim 1 , wherein the hydrogel spacer further comprises a linear polymer.
19 . The method of claim 18 , wherein the hydrogel spacer exhibits shear thinning behavior.
20 . The method of claim 18 , wherein the linear polymer comprises polyethylene glycol.
21 . A method for radiation therapy comprising introducing a hydrogel spacer at a site between a first tissue location and a second tissue location using ultrasound, wherein the hydrogel spacer increases a distance between the first tissue location and the second tissue location, the site being chosen to decrease radiation at the first tissue location when the second tissue location receives a dose of therapeutic radiation, wherein the hydrogel spacer comprises a collection of covalently-crosslinked biodegradable hydrogel particles comprising a polysaccharide.
22 . The method of claim 21 , wherein the hydrogel spacer further comprises a linear polymer.
23 . The method of claim 21 , wherein the polysaccharide comprises hyaluronic acid.
24 . A method for radiation therapy comprising imaging a site of a hydrogel spacer comprising a collection of polysaccharide particles that is positioned between a first tissue location and a second tissue location using ultrasound, wherein the hydrogel spacer establishes a distance between the first tissue location and the second tissue location, the site being chosen to decrease radiation at the first tissue location when the second tissue location receives a dose of therapeutic radiation, wherein the hydrogel spacer further comprises a linear polymer in addition to the hydrogel particles.
25 . The method of claim 24 , wherein the polysaccharide particles comprise hyaluronic acid.
26 . The method of claim 24 , wherein the polysaccharide particles are covalently-crosslinked.
27 . The method of claim 24 , wherein the polysaccharide particles are biodegradable.
28 . A method for radiation therapy comprising imaging a site of a hydrogel spacer that is positioned between a first tissue location and a second tissue location using ultrasound, wherein the hydrogel spacer establishes a distance between the first tissue location and the second tissue location, wherein the hydrogel spacer comprises hydrogel particles, wherein the hydrogel particles comprise a glycosaminoglycan that is crosslinked with a reactive precursor species having electrophilic functional groups.
29 . The method of claim 28 , wherein the hydrogel spacer further comprises a linear polymer in addition to the hydrogel particles.
30 . The method of claim 28 , wherein the hydrogel particles are biodegradable.
31 . The method of claim 28 , wherein the glycosaminoglycan is hyaluronic acid.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 16, 2025
From: CAMPBELL, PATRICK; SAWHNEY, AMARPREET S.
To: INCEPT, LLC
Reel/Frame 070855/0398 →
Continuity (9)
Provisional Application
61286450
· Dec 15, 2009
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