IP Library › Granted Patent US 11,981,717
Granted Patent B2
US 11,981,717 · App. 17/578,265 · Granted May 14, 2024

Engineered IL-2 Fc fusion proteins

Inventors: Matthew Bernett (Monrovia, CA); John Desjarlais (Pasadena, CA); Rajat Varma (Monrovia, CA); Rumana Rashid (Temple City, CA)
Assignee: Xencor, Inc.
C07K14/55C07K14/70535C12N15/85A61K38/00C07K2319/30
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Quick Facts
Patent No.
US 11,981,717
App. No.
17/578,265
Granted
May 14, 2024
Kind
B2
Abstract

The present invention provides IL-2-Fc fusion proteins comprising IL-2 variants.

Claims (5)

1. A polypeptide composition comprising a variant human IL-2 protein, wherein said variant human IL-2 protein comprises amino acid substitution(s) as compared to SEQ ID NO:2 selected from the group of T3A/D20N/T37R and T3A/D20N/N71K.

2. The polypeptide composition according to claim 1 , wherein said variant human IL-2 protein further comprises a C125S variant.

3. The polypeptide composition according to claim 1 , wherein said variant human IL-2 protein further comprises a C125A variant.

4. The polypeptide composition according to claim 1 , wherein said polypeptide composition is a heterodimeric protein complex comprising two protein monomers, wherein each protein monomer comprises said variant human IL-2 protein covalently attached to an Fc domain.

5. The polypeptide composition according to claim 4 , wherein said polypeptide composition is selected from the group consisting of XENP27564 (SEQ ID NOs:297 and 298), XENP27563 (SEQ ID NOs:295 and 296), XENP26105 (SEQ ID NOs:245 and 246), and XENP26109 (SEQ ID NOs:249 and 250).

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 30, 2026
From: LIU, KE
To: XENCOR, INC.
Reel/Frame 075475/0297 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 19, 2023
From: BERNETT, MATTHEW; DESJARLAIS, JOHN; VARMA, RAJAT; RASHID, RUMANA; SCHUBBERT, SUZANNE
To: XENCOR, INC.
Reel/Frame 065279/0409 →
Continuity (4)
Continuation 16206849 · Nov 30, 2018
Provisional Application 62675070 · May 22, 2018
Provisional Application 62607850 · Dec 19, 2017
Related Publication 20220213162A1 · Jul 7, 2022