IP Library Granted Patent US 11,740,309
Granted Patent B2
US 11,740,309 · App. 17/582,738 · Granted Aug 29, 2023

Systems and methods for dynamically extending magnetic resonance imaging of a subject

Inventors: Laura Sacolick (Guilford, CT); Carole Lazarus (Paris, FR); Rafael O'Halloran (Guilford, CT); Hadrien A. Dyvorne (New York, NY)
Assignee: Hyperfine Operations, Inc.
G01R33/543G01R33/4826G01R33/5608G01R33/56518
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Quick Facts
Patent No.
US 11,740,309
App. No.
17/582,738
Granted
Aug 29, 2023
Kind
B2
Abstract

Systems and methods are provided herein for determining whether to extend scanning performed by a magnetic resonance imaging (MRI) system. According to some embodiments, there is provided a method for imaging a subject using an MRI system, comprising: obtaining data for generating at least one magnetic resonance image of the subject by operating the MRI system in accordance with a first pulse sequence; prior to completing the obtaining the data in accordance with the first pulse sequence, determining to collect additional data to augment and/or replace at least some of the obtained data; determining a second pulse sequence to use for obtaining the additional data; and after completing the obtaining the data in accordance with the first pulse sequence, obtaining the additional data by operating the MRI system in accordance with the second pulse sequence.

Claims (50)

1. A method for imaging a subject using a magnetic resonance imaging (MRI) system, the MRI system comprising a plurality of magnetics components including at least one gradient coil and at least one radio-frequency (RF) coil, the method comprising:

obtaining data for generating at least one magnetic resonance image of the subject by operating the MRI system in accordance with a first pulse sequence;

prior to completing the obtaining the data in accordance with the first pulse sequence, determining to collect additional data to augment and/or replace at least some of the obtained data;

determining a second pulse sequence to use for obtaining the additional data, wherein determining the second pulse sequence comprises determining parameters for the second pulse sequence based on a state of the MRI system subsequent to operating the MRI system in accordance with the first pulse sequence; and

after completing the obtaining the data in accordance with the first pulse sequence, obtaining the additional data by operating the MRI system in accordance with the second pulse sequence.

2. The method of claim 1 , wherein the first pulse sequence comprises a pre-programmed number of pulse repetition periods, and

wherein completing obtaining data in accordance with the first pulse sequence comprises completing operating the MRI system for the pre-programmed number of pulse repetition periods in accordance with parameters of the first pulse sequence.

3. The method of claim 1 , wherein the first pulse sequence is one of a diffusion weighted imaging (DWI) pulse sequence or a spin echo pulse sequence.

4. The method of claim 1 , wherein:

determining to collect the additional data is performed by determining that a first subset of the data obtained in accordance with the first pulse sequence was affected by one or more artefacts; and

determining the parameters for the second pulse sequence is based on parameters of the first pulse sequence used to obtain the first subset of the data.

5. The method of claim 4 , wherein determining that the first subset of data was affected by the one or more artefacts is performed using information indicating that the subject moved during collection of the first subset of data.

6. The method of claim 5 , further comprising obtaining the information indicating that the subject moved during collection of the first subset of data, wherein obtaining the information indicating that the subject moved is performed using at least one sensor configured to detect motion of the subject.

7. The method of claim 5 , further comprising obtaining the information indicating that the subject moved during collection of the first subset of data, wherein obtaining the information indicating that the subject moved during collection of the first subset of data comprises determining that the subject moved by processing the data collected in accordance with the first pulse sequence.

8. The method of claim 4 , wherein determining that the first subset of data was affected by the one or more artefacts is performed using information indicating the presence of one or more of: external RF interference generated by one or more devices external to the MRI system, internal RF interference generated by one or more components of the MRI system outside of its imaging region, and/or noise generated by receive circuitry of the MRI system.

9. The method of claim 8 , further comprising obtaining, using one or more sensors, information indicating that the first subset of data was affected by external RF interference generated by one or more devices external to the MRI system wherein the one or more sensors include at least one RF coil positioned outside of the imaging region of the MRI system and configured to detect external RF interference.

10. The method of claim 1 , wherein determining to collect the additional data comprises:

calculating a measure of MR image quality using data collected in accordance with the first pulse sequence; and

determining to collect the additional data when the measure of MR image quality is below a specified threshold and/or outside a specified range.

11. The method of claim 1 , wherein determining to collect the additional data comprises determining to collect additional data corresponding to one or more k-space coordinates not sampled by the first pulse sequence.

12. The method of claim 1 , wherein determining parameters for the second pulse sequence comprises:

determining an initial set of parameters for one or more RF pulses and/or gradient waveforms to be generated as part of the second pulse sequence using the parameters of the first pulse sequence used to obtain the first subset of the data; and

adjusting the initial set of parameters to compensate for a presence of eddy currents during operation of the MRI system.

13. The method of claim 12 , wherein adjusting the initial set of parameters to compensate for the presence of eddy currents during operation of the MRI system comprises:

correcting a gradient waveform generated in accordance with the second pulse sequence and associated with a target gradient field using a non-linear function of a characteristic of the gradient waveform to obtain a corrected gradient waveform; and

operating the MRI system in accordance with the second pulse sequence comprises operating the MRI system in accordance with the corrected gradient waveform to generate the target gradient field.

14. The method of claim 1 , wherein determining parameters for the second pulse sequence comprises:

determining an initial set of parameters for one or more RF pulses and/or gradient waveforms to be generated as part of the second pulse sequence using the parameters of the first pulse sequence used to obtain the first subset of the data; and

adjusting the initial set of parameters to compensate for effects of hysteresis in the MRI system.

15. The method of claim 14 , wherein adjusting the initial set of parameters to compensate for effects of hysteresis in the MRI system comprises:

determining a corrected pulse sequence to control the at least one gradient coil based on the first pulse sequence and a hysteresis model of induced magnetization of the MRI system caused by operation of the at least one gradient coil; and

operating the MRI system in accordance with the second pulse sequence comprises controlling, using the corrected pulse sequence, the at least one gradient coil to generate one or more gradient pulses for imaging a patient.

16. The method of claim 1 , wherein the determining to collect additional data to augment and/or replace the at least some of the obtained data is repeated at least once during the obtaining the data in accordance with the first pulse sequence.

17. The method of claim 1 , further comprising:

prior to completing the obtaining the additional data in accordance with the second pulse sequence, determining to collect additional data to augment and/or replace at least some of the obtained additional data in accordance with the second pulse sequence;

determining a third pulse sequence to use for obtaining the additional data to augment and/or replace the at least some of the obtained additional data in accordance with the second pulse sequence; and

after completing the obtaining the additional data in accordance with the second pulse sequence, obtaining the additional data by operating the MRI system in accordance with the third pulse sequence.

18. The method of claim 1 , wherein the determining to collect additional data to augment and/or replace at least some of the obtained data is further based on a difference between a time spent obtaining the data in accordance with the first pulse sequence and an allotted time for performing imaging.

19. A magnetic resonance imaging (MRI) system for imaging a subject, the MRI system comprising:

a plurality of magnetics components including at least one gradient coil and at least one radio-frequency (RF) coil; and

at least one controller configured to:

obtain data for generating at least one magnetic resonance image of the subject by operating the MRI system in accordance with a first pulse sequence;

prior to completing the obtaining the data in accordance with the first pulse sequence, determine to collect additional data to augment and/or replace at least some of the obtained data;

determine a second pulse sequence to use for obtaining the additional data, wherein determining the second pulse sequence comprises determining parameters for the second pulse sequence based on a state of the MRI system subsequent to operating the MRI system in accordance with the first pulse sequence; and

after completing the obtaining the data in accordance with the first pulse sequence, obtaining the additional data by operating the MRI system in accordance with the second pulse sequence.

20. At least one non-transitory computer-readable storage medium having encoded thereon executable instructions that, when executed by at least one computer hardware processor, cause the at least one computer hardware processor to perform a method for imaging a subject using a magnetic resonance imaging (MRI) system, the MRI system comprising a plurality of magnetics components including at least one gradient coil and at least one radio-frequency (RF) coil, the method comprising:

obtaining data for generating at least one magnetic resonance image of the subject by operating the MRI system in accordance with a first pulse sequence;

prior to completing the obtaining the data in accordance with the first pulse sequence, determining to collect additional data to augment and/or replace at least some of the obtained data;

determining a second pulse sequence to use for obtaining the additional data, wherein determining the second pulse sequence comprises determining parameters for the second pulse sequence based on a state of the MRI system subsequent to operating the MRI system in accordance with the first pulse sequence; and

after completing the obtaining the data in accordance with the first pulse sequence, obtaining the additional data by operating the MRI system in accordance with the second pulse sequence.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 1, 2022
From: SACOLICK, LAURA; LAZARUS, CAROLE; O'HALLORAN, RAFAEL; DYVORNE, HADRIEN A.
To: HYPERFINE OPERATIONS, INC.
Reel/Frame 060068/0282 →
Continuity (2)
Provisional Application 63144727 · Feb 2, 2021
Related Publication 20220244334A1 · Aug 4, 2022