Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof
Various aspects of the present disclosure provide compositions including a water-insoluble therapeutic agent and a gallate-containing compound. Other aspects provide methods of using such compositions.
1. A composition for the treatment of a medical condition, comprising:
a topical drug preparation comprising a gallate containing compound and a water-insoluble drug, where the gallate containing compound is present in an amount by weight equal to or greater than the amount by weight of the water-insoluble drug.
2. The composition of claim 1 , where the gallate containing compound is selected from the group consisting of epi gallo catechin gallate and tannic acid.
3. The composition of claim 2 , where the topical preparation comprises a cream, paste, gel, or ointment.
4. The composition of claim 1 , where the drug is selected from paclitaxel, docetaxel, amphotericin, curcumin, retinoic acid, finasteride, and lidocaine.
5. The composition of claim 1 , where the drug is an anesthetic.
6. The composition of claim 5 , where the preparation is nonaqueous.
7. The composition of claim 5 , where the topical preparation comprises a cream, paste, gel, or ointment.
8. The composition of claim 5 , where the drug is lidocaine.
9. The composition of claim 5 , where the topical drug preparation comprises a eutectic solution.
10. The composition of claim 9 , where the solution comprises menthol.
11. The composition of claim 1 , where the drug has a molecular weight greater than 500 Daltons.
12. The composition of claim 1 , further comprising a solubilizing excipient.
13. The composition of claim 1 , where the topical drug preparation comprises a eutectic solution.
14. The composition of claim 12 , where the solution comprises menthol.
15. The composition of claim 1 , where the weight ratio of gallate containing compound:water-insoluble drug is in the range of 200:1 to 1:1, 200:1 to 5:1, 200:1 to 10:1, 200:1 to 30:1, 200:1 to 50:1, 100:1 to 1:1, 100:1 to 5:1, 100:1 to 10:1, 100:1 to 30:1, 100:1 to 50:1, 50:1 to 1:1, 50:1 to 5:1, 10:1 to 1:1, or 10:1 to 5:1.
16. The composition of claim 1 , where the topical preparation comprises a cream, paste, gel, or ointment.
17. The composition of claim 1 , where the topical preparation comprises a preblended solid or semi solid matrix of the gallate containing compound and the drug.
18. The composition of claim 1 , where the gallate containing compound and the drug are predispersed in one of a membrane, a hydrogel, an electrospun film, or a skin dressing.
19. The composition of claim 1 , where the preparation is nonaqueous.