Nogapendekin Alfa-Inbakicept For Immune Stimulant Therapies And Treatment Of Viral Infections
Pharmaceutical compositions comprising an IL-15 agonist or derivative thereof, such as nogapendekin alfa-inbakicept (NAI), are provided herein for enhancing immunity and for inhibiting viral infections. The IL-15 agonist or derivative thereof may be used to increase proliferative capacity and/or cytotoxicity of various immune competent cells, and especially NK and cytotoxic T cells in healthy individuals. The IL-15 agonist or derivative thereof may be used alone or in combination with one or more other therapeutic agents, such as in conjunction with a vaccine.
1 . A method for preventing, reducing the occurrence of, or treating a viral infection in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an IL-15 agonist, wherein the viral infection is not an HIV infection or an HPV infection.
2 . The method of claim 1 , wherein the IL-15 agonist is nogapendekin alfa-imbakicept (NAI).
3 . The method of any one of the previous claims, wherein the IL-15 agonist is administered at least once per week.
4 . The method of claim 3 , wherein the IL-15 agonist is administered once per week.
5 . The method of claim 3 , wherein the IL-15 agonist is administered twice per fortnight.
6 . The method of claim 3 , wherein the IL-15 agonist is administered once every three weeks.
7 . The method of any one of the previous claims, wherein the therapeutically effective amount of the IL-15 agonist is between about 10 μg and about 500 μg per dose.
8 . The method of claim 7 , wherein the therapeutically effective amount of the IL-15 agonist is about 50 μg per dose.
9 . The method of any one of the previous claims, wherein the IL-15 agonist is administered subcutaneously or intravenously.
10 . The method of any one of the previous claims, wherein the subject is human.
11 . The method of any one of the previous claims, wherein the viral infection is caused by a DNA virus.
12 . The method of claim 11 , wherein the DNA virus is selected from the group consisting of papillomaviridae, herpesviridae, adenoviridae, polyomavididae, and poxviridae.
13 . The method of claim 12 , wherein the DNA virus is selected from the group consisting of human papilloma virus, human herpesvirus, and varicella zoster virus.
14 . The method of any one of claims 1 - 10 , wherein the viral infection is caused by an RNA virus.
15 . The method of claim 14 , wherein the RNA virus is selected from the group consisting of reoviridae, coronaviridae, picornaviridae, flaviviridae, hepeviridae, togaviridae, filoviridae, paramyxoviridae, pneumoviridae, retroviridae, rhabdoviridae, hantaviridae, and orthomyxoviridae.
16 . The method of claim 15 , wherein the RNA virus is selected from the group consisting of rotavirus, coronavirus, SARS virus, poliovirus, rhinovirus, hepatitis A virus, yellow fever virus, west nile virus, hepatitis C virus, dengue fever virus, zika virus, rubella virus, sindbis virus, Chikungunya virus, Ebola virus, Marburg virus, measles virus, mumps virus, respiratory syncytial virus, rabies virus, human immunodeficiency virus, influenza virus A, influenza virus B, influenza virus C, and influenza virus D.
17 . The method of claim 16 , wherein the RNA virus is coronavirus, human immunodeficiency virus, influenza virus A, influenza virus B, influenza virus C, or influenza virus D.
18 . The method of any one of the previous claims further comprising administering to the subject a therapeutically effective amount of one or more of an interleukin; a TNF-α antagonist; a type 1 interferon (IFN); chloroquine and/or chloroquine phosphate; an anti-viral agent; an antibiotic; and/or a corticosteroid such as prednisone and prednisolone.
19 . The method of claim 18 , wherein the interleukin is IL-1 and/or IL-6.
20 . The method of claim 18 , wherein the TNF-α antagonist is infliximab, adalimumab, certolizumab pegol, golimumab and/or etanercept.
21 . The method of claim 18 , wherein the type 1 interferon (IFN) is IFN-α and/or IFN-β.
22 . The method of claim 17 , wherein the coronavirus is coronavirus disease 2019 (COVID-19) virus and/or or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
23 . The method of claim 22 , further comprising administering to the subject a therapeutically effective amount of one or more of chloroquine; chloroquine phosphate; an anti-viral agent; an antibiotic; a corticosteroid, and/or oxygen to the subject in need thereof.
24 . The method of any one of the previous claims, wherein activation of the virus is suppressed.
25 . A method for enhancing an immune response or preventing or reducing the likelihood of cancer in a healthy individual, the method comprising administering to the individual a composition comprising an IL-15 agonist at a dose that increases the proliferative capacity and/or cytotoxicity of a NK cell or a T cell.
26 . The method of claim 25 , wherein the IL-15 agonist is NAI.
27 . The method of any one of claims 25 - 26 , wherein the individual is at least 50 years of age, at least 55 years of age, or at least 60 years of age.
28 . The method of any one of claims 25 - 27 , wherein the individual has one or more of the following:
a. a total T cell count that is at or below a bottom quartile for a reference range for the total T cell count;
b. a total NK cell count that is at or below a bottom quartile for a reference range for the total NK cell count; and/or
c. a total memory cell count that is at or below a bottom quartile for a reference range for the total memory cell count.
29 . The method of any one of claims 25 - 28 , wherein the individual is a healthcare professional or a teacher.
30 . The method of any one of claims 25 - 29 , wherein the individual is predisposed to infectious diseases or cancer and/or has a family history of predisposition to infectious diseases or cancer.
31 . The method of any one of claims 25 - 30 , wherein the IL-15 agonist is administered within 14 days of administration of a vaccine composition.
32 . The method of any one of claims 25 - 31 , wherein viral activation of a latent virus is suppressed.
33 . The method of claim 32 , wherein the latent virus is a dormant varicella zoster virus or a human papillomavirus.
34 . The method of any one of claims 25 - 33 , wherein the IL-15 agonist is administered prior to administration of an immune compromising therapy.
35 . The method of claim 34 , wherein the immune compromising therapy is radiation therapy or chemotherapy.
36 . The method of any one of claims 25 - 35 , wherein the IL-15 agonist is administered to increase a total T cell count and/or a total NK cell count by at least 10%.
37 . The method of any one of claims 25 - 36 , wherein the step of administering comprises subcutaneous injection of the IL-15 agonist.
38 . The method of claim 37 , wherein the step of administering comprises multiple subcutaneous injections of the IL-15 agonist at a monthly or quarterly schedule.
39 . The method of any one of claims 25 - 38 , wherein the therapeutically effective amount of the IL-15 agonist is about 1-10 μg/kg per dose.
40 . The method of any one of claims 25 - 39 , wherein the therapeutically effective amount of the IL-15 agonist is about 10-25 μg/kg per dose.