GAS DELIVERY SYSTEM
A gas delivery system is provided. The gas delivery system includes a pump operable to receive blood from a patient. A gas transfer unit is in fluid communication with the pump and operable to receive the blood from the pump and deliver a therapeutic amount of xenon gas to the blood. A patient connector withdraws and/or infuses the blood into the patient.
1 . A gas delivery system for delivering xenon gas to a patient, the gas delivery system comprising:
a pump operable to receive blood from a patient;
a gas transfer unit in fluid communication with the pump and operable to receive the blood from the pump and deliver a therapeutic amount of xenon gas to the blood; and
a patient connector operable to withdraw and/or infuse the blood into the patient.
2 . The gas delivery system of claim 1 , wherein the patient is awake.
3 . The gas delivery system of claim 1 , wherein the patient is non-intubated.
4 . The gas delivery system of claim 1 , further comprising:
a first gas detection sensor located upstream from the gas transfer unit and operable to measure a first concentration of the xenon in the blood prior to passing through the gas transfer unit; and
a second gas detection sensor located downstream from the gas transfer unit and operable to measure a second concentration of xenon in the blood after passing through the gas transfer unit.
5 . The gas delivery system of claim 4 , further comprising: a controller coupled with the gas transfer unit, the first gas detection sensor, and the second gas detection sensor, the controller being operable to:
receive the first concentration of xenon from the first gas detection sensor;
receive the second concentration of xenon from the second gas detection sensor;
compare the first concentration and the second concentration;
determine, when the first concentration is less than the second concentration gas, an additional amount of xenon gas to be delivered to the blood; and
adjust, when the first concentration is less than the second concentration, the gas transfer unit to deliver the additional amount of xenon to the blood such that the blood includes the therapeutic amount of xenon.
6 . The gas delivery system of claim 5 , wherein the controller automatically determines the additional amount of xenon gas to be delivered to the blood.
7 . The gas delivery system of claim 1 , wherein the gas transfer unit is further operable to deliver a predetermined amount of oxygen gas to the blood.
8 . The gas delivery system of claim 1 , wherein the gas transfer unit is included in an extracorporeal membrane oxygenation (ECMO) system.
9 . The gas delivery system of claim 1 , wherein the pump includes a centrifugal pump.
10 . The gas delivery system of claim 1 , wherein the patient connector further includes:
a first conduit in fluidic communication with the pump and the gas transfer unit operable to be inserted into the patient to withdraw the blood;
a second conduit in fluidic communication with the pump and the gas transfer unit operable to be inserted into the patient such that the blood is infused into the patient.
11 . The gas delivery system of claim 10 , wherein the first conduit is operable to be inserted into and be in fluidic communication with a vein of the patient, and the second conduit is operable to be inserted into and be in fluidic communication with an artery of the patient.
12 . The gas delivery system of claim 1 , further comprising:
a temperature unit operable to maintain the blood at a predetermined temperature.
13 . A method of preventing or inhibiting reperfusion injury in a patient with ischemia, the method comprising:
withdrawing blood from a patient;
pumping the withdrawn blood through a gas transfer unit;
delivering, by the gas transfer unit, a therapeutic amount of xenon gas to the withdrawn blood; and
pumping the blood from the gas transfer unit to the patient.
14 . The method of claim 13 , wherein the patient is awake.
15 . The method of claim 13 , wherein the patient is non-intubated.
16 . The method of claim 13 , further comprising:
measuring, by a first gas detection sensor, a first concentration of the xenon in the blood prior to passing through the gas transfer unit; and
measuring, by a second gas detection sensor, a second concentration of xenon in the blood after passing through the gas transfer unit.
17 . The method of claim 16 , further comprising:
comparing, by a controller, the first concentration and the second concentration;
determining, by the controller when the first concentration is less than the second concentration, an additional amount of xenon gas to be delivered to the blood;
adjusting, by the controller when the first concentration is less than the second concentration, the gas transfer unit to deliver the additional amount of xenon to the blood such that the blood includes the therapeutic amount of xenon gas.
18 . The method of claim 17 , further comprising:
wherein the controller automatically determines the additional amount of xenon gas to be delivered to the blood.
19 . The method of claim 13 , further comprising:
delivering a predetermined amount of oxygen gas to the blood.
20 . The method of claim 13 , wherein the gas transfer unit is included in an extracorporeal membrane oxygenation (ECMO) system.
21 . The method of claim 13 , wherein the pump includes a centrifugal pump.
22 . The method of claim 13 , further comprising:
inserting a first conduit into the patient to withdraw the blood; and
inserting a second conduit into the patient to infuse the blood into the patient.
23 . The method of claim 19 , wherein the first conduit is operable to be inserted into and be in fluidic communication with a vein of the patient, and the second conduit is operable to be inserted into and be in fluidic communication with an artery of the patient.