SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS
Compounds are provided having the structure of Formula (I), or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R b1 and R b2 are as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate receptor, and have utility for treatment of a malcondition for which activation of this receptor is medically indicated.
1 . A compound having the structure of Formula (I):
or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R b1 and R b2 are independently:
hydrogen, alky or substituted alkyl;
or R b1 and R b2 are taken together with the nitrogen to which they are attached form heterocyclyl or substituted heterocylyl.
2 . The compound of claim 1 wherein R b1 and R b2 are independently hydrogen, alky or substituted alkyl.
3 . The compound of claim 1 wherein R b1 and R b2 taken together with the nitrogen to which they are attached form heterocyclyl or substituted heterocylyl.
4 . The compound of claim 1 wherein the compound has one of the following structures, or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof:
Cpd No.
Structure
3-1
3-2
3-3
3-4
3-5
3-6
3-7