SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS
Compounds are provided having the structure of Formula (I) or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R a is as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate receptor, and have utility for treatment of a malcondition for which activation of this receptor is medically indicated.
1 . A compound having the structure of Formula (I):
or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein:
R a is:
alkanediyl-OR a1 ,
alkanediyl-C(═O)OR a2 ,
alkyl or substituted alkyl,
aryl, alkaryl, substituted aryl or substituted alkaryl,
heterocyclyl, substituted heterocyclyl, heterocyclyalkyl or substituted heterocyclylalkyl; and
R a1 and R a2 are independently H or C 1-4 alkyl.
2 . The compound of claim 1 wherein R a is alkanediyl-OR a1 .
3 . The compound of claim 1 wherein R a is alkanediyl-C(═O)OR a2 .
4 . The compound of claim 1 wherein R a is alkyl or substituted alkyl.
5 . The compound of claim 1 wherein R a is substituted alkyl.
6 . The compound of claim 1 wherein R a is aryl, alkaryl, substituted aryl or substituted alkaryl.
7 . The compound of claim 1 wherein R a is heterocyclyl, substituted heterocyclyl, heterocyclyalkyl or substituted heterocyclylalkyl.
8 . The compound of claim 1 wherein the compound has one of the following structures, or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof:
Cpd
No.
Structure
2-1
2-2
2-3
2-4
2-5
2-6
2-7
2-8
2-9
2-10
2-11
2-12
2-13
2-14
2-15
2-16
2-17
2-18
2-19
2-20
2-21
2-22
2-23
2-24
2-25
2-26
2-27
2-28
2-29
2-30
2-31
2-32
2-33
2-34
2-35
2-36
2-37
2-38
2-39
2-40
2-41