Granted Patent B2

US 12,419,823 · App. 17/600,010 · Granted Sep 23, 2025

Inventors: Ying Zhang (Woodbury, MN); Robert A. Asmus (Hudson, WI); Zhicheng Tian (Woodbury, MN); Kheng Vang (St. Paul, MN); James P. Dizio (St. Paul, MN); Patrick J. Parks (Mendota Heights, MN); Brian E. Spiewak (Inver Grove Heights, MN)

Assignee: Solventum Intellectual Properties Company

A61K8/4926A61K8/342A61K8/345A61K8/375A61Q17/005

Abstract

Claims (24)

1. An antimicrobial composition comprising:

60 wt. % to 99.4 wt. % solubilizer, the solubilizer selected from glyceryl monoisostearate, glyceryl monooleate, decagylcerol hexaoleate, decagylcerol decaoleate, and a combination thereof;

0.1 wt. % to 10 wt. % antimicrobial agent, the antimicrobial agent selected from octenidine dihydrochloride, octenidine gluconate, octenidine sulfate, octenidine acetate, and a combination thereof; and

0.1 wt. % to 15 wt. % cidatrope, the cidatrope selected from diisopropyl adipate, dibutyl sebacate, triethyl citrate, acetyltributyl citrate, trioctyldodecyl citrate, PPG-10 butanediol, and a combination thereof,

wherein the composition is substantially free of water and a C 2 -C 5 alcohol.

2. The antimicrobial composition of claim 1 , wherein the solubilizer is glyceryl monoisostearate.

3. The antimicrobial composition of claim 1 , wherein the cidatrope is diisopropyl adipate, dibutyl sebacate, or a combination thereof.

4. The antimicrobial composition of claim 1 , wherein the cidatrope is selected from diisospropyl adipate, dibutyl sebacate, triethyl citrate, PPG-10 butanediol, and a combination thereof.

5. The antimicrobial composition of claim 1 , wherein the cidatrope is selected from the group consisting of triethyl citrate, acetyltributyl citrate, trioctyldodecyl citrate, and a combination thereof.

6. The antimicrobial composition of claim 1 , wherein the antimicrobial agent is octenidine dihydrochloride.

7. The antimicrobial composition of claim 1 , wherein the cidatrope and antimicrobial agent are present at a weight ratio of 8:1 to 10:1 cidatrope:antimicrobial agent.

8. The antimicrobial composition of claim 7 , wherein the solubilizer is glyceryl monoisostearate.

9. The antimicrobial composition of claim 8 , wherein the cidatrope selected from triethyl citrate, acetyltributyl citrate, trioctyldodecyl citrate, and a combination thereof.

10. The antimicrobial composition of claim 8 , wherein the cidatrope is selected from diisospropyl adipate, dibutyl sebacate, triethyl citrate, PPG-10 butanediol, and a combination thereof.

11. The antimicrobial composition of claim 7 , wherein the solubilizer is glyceryl monoisostearate and the antimicrobial agent is octenidine dihydrochloride.

12. The antimicrobial composition of claim 7 , wherein the cidatrope selected from triethyl citrate, acetyltributyl citrate, trioctyldodecyl citrate, and a combination thereof.

13. The antimicrobial composition of claim 7 , wherein the cidatrope is selected from diisospropyl adipate, dibutyl sebacate, triethyl citrate, PPG-10 butanediol, and a combination thereof.

14. The antimicrobial composition of claim 1 , wherein the solubilizer is glyceryl monoisostearate.

15. The antimicrobial composition of claim 1 , wherein the solubilizer is glyceryl monoisostearate and the antimicrobial agent is octenidine dihydrochloride.

16. A personal care product comprising the antimicrobial composition of claim 1 .

17. The personal care product of claim 16 , wherein the personal care product is selected from the group consisting of an antimicrobial dressing, a skin preparation, a bathing formulation, and a nasal spray.

18. A method of killing or inactivating microorganisms on a mammalian tissue, the method comprising:

contacting the mammalian tissue with an antimicrobial composition of claim 1 .

19. The method of claim 18 , wherein the solubilizer is glyceryl monoisostearate and the antimicrobial agent is octenidine dihydrochloride.

Assignments (2)

Continuity (2)

References Cited (21)