CANNABINOID-COMPRISING COMPOSITIONS FOR MANAGEMENT OF PAIN
There are provided compositions comprising a purified cannabidiol (CBD) or a derivative thereof and an anti-inflammatory botanical extract, and methods of use thereof for the management of pain in a subject.
1 . A composition comprising:
a purified cannabidiol (CBD) or a derivative thereof; and
an anti-inflammatory botanical extract comprising Arnica extract and Boswellia extract.
2 . The composition according to claim 1 , further comprising
at least one purified terpene or a derivative thereof.
3 . The composition according to claim 1 , wherein the composition is in a form suitable for topical administration to a subject.
4 .- 9 . (canceled)
10 . The composition according to claim 2 , wherein the at least one purified terpene or the derivative thereof is one or more of: bisabolol, cadinene, caryophyllene or beta-caryophyllene, camphor, capsaicin, carvacrol, copaene, farnesol, guaia-1 (10),11-diene, humulene, isoborneol, γ-linolenic acid, methyl salicylate, β-sitosterol, brassicasterol, stigmasterol, campesterol and γ-terpinene.
11 . (canceled)
12 . The composition according to claim 2 , wherein the at least one purified terpene or the derivative thereof comprises bisabolol.
13 .- 14 . (canceled)
15 . The composition according to claim 2 , wherein the at least one purified terpene or the derivative thereof comprises capsaicin.
16 . The composition according to claim 2 , wherein the at least one purified terpene or the derivative thereof comprises beta-caryophyllene.
17 . The composition according to claim 1 , wherein the purified cannabidiol or the derivative thereof is present in the composition in an amount between about 2 wt % and about 6 wt % of the total weight of the composition.
18 . (canceled)
19 . The composition according to claim 2 , wherein the at least one purified terpene or the derivative thereof is present in the composition in an amount between about 0.25 wt % and about 20 wt % of the total weight of the composition.
20 . The composition according to claim 2 , wherein the at least one purified terpene or the derivative thereof is present in the composition in an amount between about 0.25 wt % and about 8 wt % of the total weight of the composition.
21 .- 26 . (canceled)
27 . The composition according to claim 1 , wherein the composition comprises one or more of: Coco Caprylate: Polawax™ NF; Isopropyl myristate; MCT Oil; Ethylhexyl glycerin; Phenoxyethanol; Vitamin E; Polysorbate 60; Copaiba Balsam Essential Oil; Angelica Root Extract; Wild Yam Extract; Polysorbate 80; Span™ 60; Aloe Vera juice; EDTA Disodium Dihydrate; Sorbitol; Xanthan Gum; and Tazman Pepper™.
28 . The composition according to claim 1 , wherein the anti-inflammatory botanical extract is present in the composition in an amount of between about 0.5 wt % and about 90 wt % of the total weight of the composition.
29 .- 31 . (canceled)
32 . A method for management of pain in a subject, the method comprising administering the composition as defined in claim 1 to the subject.
33 . A method for alleviating pain in a subject, the method comprising administering the composition as defined in claim 1 to the subject.
34 . A method for treating pain in a subject, the method comprising administering the composition as defined in claim 1 to the subject.
35 .- 38 . (canceled)
39 . The composition according to claim 2 , wherein the at least one purified terpene or the derivative thereof comprises menthol, camphor, or a combination thereof.
40 . The composition according to claim 1 , wherein the purified cannabidiol or the derivative thereof is present in the composition in an amount between about 1 wt % and about 10 wt % of the total weight of the composition.
41 . The composition according to claim 1 , wherein the anti-inflammatory botanical extract is present in the composition in an amount of between about 5 wt % and about 10 wt % of the total weight of the composition.
42 . A composition for topical application comprising:
a purified cannabidiol (CBD) or a derivative thereof in an amount between about 1 wt % and about 10 wt % of the total weight of the composition; and
an anti-inflammatory botanical extract in an amount of between about 0.5 wt % and about 90 wt % of the total weight of the composition, wherein the anti-inflammatory botanical extract comprises Arnica extract and Boswellia extract.
43 . A composition for topical application comprising:
a purified cannabidiol (CBD) or a derivative thereof;
an anti-inflammatory botanical extract in an amount of between about 0.5 wt % and about 90 wt % of the total weight of the composition, wherein the anti-inflammatory botanical extract comprises Arnica extract and Boswellia extract; and
at least one purified terpene or a derivative thereof.