Removable Film-Forming Gel Compositions Featuring Adhesion Promoters
Film-forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, an amine-rich adhesion promoter, and a volatile solvent. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing. In some cases, the film-forming gel composition can include lidocaine.
1 . A gel composition for use as a conformable film bandage, the gel composition comprising:
a silicone containing, film-forming polymer;
an amine-rich adhesion promoter;
a volatile solvent; and
active ingredient,
wherein a film cast from the gel composition is self-supporting on a biological substrate and can be peeled off the substrate.
2 . The gel composition of claim 1 , further comprising a penetration enhancer.
3 . The gel composition of claim 2 , wherein the penetration enhancer is selected from the group consisting of: diethylene glycol monoethyl ether, diisoproyl adipate, dipropylene glycol, ethyl oleate, glyceryl monooleate, isopropyl myristate, isopropyl palmitate, isostearic acid, lauryl lactate, methyl laurate, octisalate, octyldodecanol, oleic Acid, oleyl alcohol, oleyl oleate, propylene plycol monolaurate, sorbitan monooleate, triacetin, and any combinations thereof.
4 . The gel composition of claim 1 , wherein the active ingredient comprises lidocaine.
5 . The gel composition of claim 2 , wherein the active ingredient comprises lidocaine.
6 . The gel composition of claim 3 , wherein the active ingredient comprises lidocaine.
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8 . The gel composition of claim 4 , wherein the film cast from the gel composition comprises lidocaine in an amount of between about 1% and about 5% by weight.
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10 . A gel composition for use as a conformable film bandage, the gel composition comprising:
a silicone containing, film-forming polymer;
an amine-rich adhesion promoter;
a volatile solvent;
penetration enhancer; and
lidocaine.
11 . A film-forming gel composition for use as a conformable film bandage, the composition
comprising:
a silicone containing polymer;
a tackifier comprising a silicate tackifying resin;
a coagulant comprising a cationic polymer; and
a volatile solvent,
wherein a film cast from the composition is self-supporting on a biological substrate and can be peeled off the substrate without substantially compromising the integrity of the film or the substrate.
12 . A conformable film bandage comprising:
a silicone containing, film-forming polymer;
an amine-rich adhesion promoter;
a volatile solvent;
penetration enhancer; and
lidocaine.
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