Adhesive compositions
Adhesive compositions are disclosed that include an octenidine salt, a resin system, a plasticizer, and a cidatrope. The dried adhesive compositions are substantially free of water and C 2 -C 5 alcohols. The adhesive compositions disclosed are formulations that provide rapid and persistent antimicrobial activity and may be useful, for example, in wound dressings, surgical drapes, and medical tapes.
1. An adhesive composition comprising:
40 wt. % to 90 wt. % resin system, wherein the resin system is a pressure-sensitive adhesive comprising a polymer prepared from:
70 wt. % to 95 wt. % of a first monomer, wherein the first monomer is a low Tg acrylate monomer selected from the group consisting of iso-octyl acrylate, 2-ethyl hexyl acrylate, 2-octyl acrylate, and butyl acrylate;
1 wt. % to 25 wt. % of a second monomer, wherein the second monomer is a polar, non-acidic monomer selected from the group consisting of acrylamide, N-vinyl pyrrolidone, and hydroxyl alkyl acrylate; and
0 wt. % to 20 wt. % vinyl acetate or butyl vinyl ether;
0 wt. % to 59.49 wt. % plasticizer,
0.01 wt. % to 10 wt. % octenidine salt, and
0.5 wt. % to 59.99 wt. % cidatrope, the cidatrope selected from a C 8 -C 26 alcohol, a C 8 -C 26 ether, a C 8 -C 26 amide, a C 8 -C 26 ester, or a combination thereof;
water in an amount less than 1 wt %; and
C 2 -C 5 alcohol in an amount less than 1 wt %,
wherein wt % is based on the weight of the adhesive composition.
2. The adhesive composition of claim 1 , wherein the first monomer is iso-octyl acrylate and the second monomer is acrylamide.
3. The adhesive composition of claim 1 , wherein the polymer comprises vinyl acetate or butyl vinyl ether.
4. The adhesive composition of claim 1 , wherein the modulus of the pressure sensitive adhesive is 10,000 to 200,000 Pa at 25° C.
5. The adhesive composition of claim 1 , wherein the resin system is characterized by a modulus of 50,000 to 1,000,000 Pa at 25° C.
6. The adhesive composition of claim 1 , wherein the plasticizer is selected from the group consisting of glyceryl monoisostearate, glyceryl monooleate, decagylcerol hexaoleate, decagylcerol decaoleate, acetyltributyl citrate, and combinations thereof.
7. The adhesive composition of claim 1 , wherein the composition is a dried composition.
8. The adhesive composition of claim 1 , wherein the cidatrope and the octenidine salt are present in a weight percentage ratio of cidatrope:octenidine salt of 0.1:1 to 3000:1.
9. The adhesive composition of claim 1 , wherein the octenidine salt is selected from the group consisting of octenidine dihydrochloride, octenidine gluconate, octenidine sulfate, octenidine acetate, and combinations thereof.
10. The adhesive composition of claim 1 , wherein the plasticizer is glyceryl monoisostearate and the cidatrope is triethyl citrate.
11. The adhesive composition of claim 1 , wherein the cidatrope is a C 8 -C 26 alcohol selected from the group consisting of 1-tetradecanol, hexadecanol, 16-methyl-1-heptadecanol, and combinations thereof.
12. The adhesive composition of claim 1 , wherein the cidatrope is a C 8 -C 26 ether that is a propoxylated C 2 to C 18 alcohol having a degree of propoxylation of 2 to 50 moles per mole of alcohol.
13. The adhesive composition of claim 1 , wherein the cidatrope is a C 8 -C 26 amide is-selected from the group consisting of a coconut fatty acid monoethanol amide, a coconut fatty acid methyl ethanolamide, an alkyl alkanolamide, and a combinations thereof.
14. The adhesive composition of claim 1 , wherein the cidatrope is a C 8 -C 26 ester is selected from the group consisting of diisopropyl adipate, dibutyl sebacate, triethyl citrate, tributyl citrate, octyldodecyl neopentanoate, laureth-2-acetate, isopropyl myristate, trioctyldodecyl citrate, myristyl myristate, cetyl acetate, and a combinations thereof.
15. An article comprising:
a substrate, and
an adhesive composition according to claim 1 ,
wherein the adhesive composition contacts at least a portion of a surface of the substrate.
16. The article according to claim 15 , wherein the article is a medical article.
17. The article according to claim 16 , wherein the medical article is a self-adhesive dressing, a surgical drape, or a medical tape.