SSTR-TARGETED CONJUGATES AND FORMULATIONS THEREOF
Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, have been designed. Such conjugates can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
1 . A pharmaceutical composition comprising
or a pharmaceutically acceptable salt thereof, acetate buffer, mannitol, and solutol.
2 . The pharmaceutical composition of claim 1 , wherein the acetate buffer has a strength of at least 30 mM.
3 . The pharmaceutical composition of claim 1 , wherein the acetate buffer has a strength of at least 40 mM.
4 . The pharmaceutical composition of claim 1 , wherein the mannitol has a concentration of about 5%.
5 . The pharmaceutical composition of claim 1 , wherein the solutol has a concentration of about 2%.
6 . A method of treating tumor comprising administering Conjugate 57 or a pharmaceutically acceptable salt thereof to a subject in need thereof, wherein the dose of Conjugate 57 is based on the body surface area (BSA) of the subject, and wherein the dose of Conjugate 57 is 8.8 mg/m 2 or less than 8.8 mg/m2.
7 . The method of claim 6 , wherein the tumor is a neuroendocrine tumor (NET).
8 . The method of claim 6 , wherein the tumor selected from the group consisting of gastroenteropancreatic (GEP), gastrointestinal (GI), pancreatic, lung, prostate, and thymus neuroendocrine tumor.
9 . The method of claim 6 , wherein the tumor is small cell lung cancer (SCLC) or large cell neuroendocrine carcinoma (LCNEC) of the lung.