Dressing Employing Features For Protection Against Maceration
Dressings for treating a tissue site with negative pressure are disclosed, which may include a dressing having multiple layers and incorporating a material adapted to neutralize proteolytic enzymes. In one example embodiment, a dressing may include a first layer comprising a hydrophobic gel having a plurality of apertures. A material adapted to neutralize proteolytic enzymes may be applied to a surface of the first layer. The dressing may further include a second layer comprising a fenestrated film and coupled to the first layer. Additionally, the dressing may include a third layer comprising a manifold, which in some instances may be a polymeric foam. The dressing may further include a fourth layer comprising a polymer drape.
1 . A dressing for treating a tissue site, comprising:
a first layer comprising a hydrophobic gel having at least one treatment aperture;
a second layer adjacent to the first layer, the second layer comprising a material adapted to neutralize proteolytic enzymes;
a third layer adjacent to the first layer, the third layer comprising a polymer film having a plurality of fluid restrictions that are configured to expand in response to a pressure gradient;
a fourth layer adjacent to the third layer and on the opposite side of the third layer from the first layer, the fourth layer comprising a manifold; and
a fifth layer adjacent to the fourth layer opposite the third layer, the fifth layer comprising a polymer drape.
2 . The dressing of claim 1 , wherein the material adapted to neutralize proteolytic enzymes comprises a sacrificial substrate.
3 . The dressing of claim 1 , wherein the material adapted to neutralize proteolytic enzymes comprises one or both of an enzyme sequestrator or an enzyme deactivator.
4 . (canceled)
5 . The dressing of claim 1 , wherein the second layer comprises a plurality of perforations.
6 . (canceled)
7 . The dressing of claim 1 , wherein the second layer comprises a biologically-derived polymer.
8 . The dressing of claim 1 , wherein the second layer comprises one or a combination of collagen, gelatin, collagen-like proteins, collagen-like peptides, cellulose, or cellulose derivative.
9 . (canceled)
10 . (canceled)
11 . (canceled)
12 . (canceled)
13 . The dressing of claim 1 , wherein the second layer comprises collagen and oxidized regenerated cellulose.
14 . The dressing of claim 1 , wherein the second layer forms a ring.
15 . (canceled)
16 . The dressing of claim 1 , wherein the second layer comprises an opening aligned with the treatment aperture.
17 . The dressing of claim 1 , wherein the second layer comprises an opening having a width in a range of about 3 centimeters to about 35 centimeters.
18 . The dressing of claim 1 , wherein the second layer has a thickness of between 5 micrometers and 500 micrometers.
19 . (canceled)
20 . The dressing of claim 1 , wherein the second layer comprises approximately 20-80% collagen and 80-20% ORC by weight.
21 . The dressing of claim 1 , wherein the second layer comprises approximately 55% collagen and 45% ORC by weight.
22 . (canceled)
23 . The dressing of claim 1 , wherein the material adapted to neutralize proteolytic enzymes is present at a higher concentration in a perimeter portion than at a center portion of the second layer.
24 . The dressing of claim 1 , wherein the material adapted to neutralize proteolytic enzymes is present in a concentration having a circular gradient increasing from a center portion of the second layer to a perimeter of the second layer.
25 . (canceled)
26 . (canceled)
27 . (canceled)
28 . (canceled)
29 . (canceled)
30 . (canceled)
31 . (canceled)
32 . (canceled)
33 . The dressing of claim 1 , wherein the fluid restrictions of the third layer comprise a plurality of slots, each of the slots having a length of less than 4 mm and a width of less than 2 mm.
34 . (canceled)
35 . (canceled)
36 . (canceled)
37 . (canceled)
38 . A system for treating a tissue site, comprising:
the dressing of claim 1 ; and
a negative-pressure source adapted to be fluidly coupled to the dressing.
39 . (canceled)
40 . A dressing for treating a tissue site with negative pressure, comprising:
a first layer comprising a perforated silicone gel coating;
a second layer coupled to the first layer and comprising an enzyme-modulating material; and
a polymer drape adjacent to the first layer opposite the second layer, the polymer drape comprising an adhesive coating.
41 . (canceled)
42 . The dressing of claim 40 , further comprising:
a third layer positioned between the first layer and the polymer drape, the third layer comprising a non-porous material and a plurality of fenestrations; and
a manifold layer between the third layer and the polymer drape.
43 . (canceled)
44 . The dressing of claim 40 , wherein the enzyme-modulating material of the second layer comprises a sacrificial substrate, and wherein the sacrificial substrate comprises collagen, gelatin, chemically-modified cellulose, hyaluronic acid, chondroitin sulfate, collagen-mimic peptides, or combinations thereof.
45 . (canceled)
46 . The dressing of claim 40 , wherein the enzyme-modulating material of the second layer comprises an enzyme deactivator, and wherein the enzyme deactivator comprises MMP inhibitors, small-molecule protease inhibitors, or combinations thereof.
47 . (canceled)
48 . The dressing of claim 40 , wherein the enzyme-modulating material of the second layer comprises an enzyme sequestrator.
49 . The dressing of claim 48 , wherein the enzyme sequestrator comprises a chelating agent, and wherein the chelating agent comprises EDTA, EGTA, or a combination thereof.
50 . (canceled)
51 . The dressing of claim 48 , wherein the enzyme sequestrator comprises a metalloprotein inhibitor having at least one zinc-binding group.
52 . (canceled)
53 . (canceled)
54 . (canceled)
55 . (canceled)
56 . (canceled)
57 . (canceled)
58 . (canceled)
59 . The dressing of claim 40 , wherein the enzyme-modulating material of the second layer is present at a higher concentration in a perimeter portion of the second layer than at a center portion of the second layer.
60 . (canceled)
61 . The dressing of claim 40 , further comprising a protease inhibitor comprising TIMPs, thrombospondin-1, thrombospondin-2, elastase inhibitor 2, alpha 1 antitrypsin, pepstatin A, aprotinin, EDTA, leupeptin, and combinations thereof.
62 . (canceled)
63 . A dressing for treating a tissue site with negative pressure, comprising:
a first layer comprising a hydrophobic gel having a plurality of apertures;
a second layer comprising a material adapted to neutralize proteolytic enzymes, the second layer having a plurality of fenestrations; and
a third layer adapted to be positioned adjacent to the first layer opposite the second layer, the third layer comprising a polymer drape.
64 . A dressing for treating a tissue site with negative pressure, comprising:
a first layer comprising a hydrophobic gel having a plurality of apertures;
a second layer adapted to be coupled to the first layer, the second layer comprising a polymer film having a plurality of fenestrations;
a third layer adapted to be positioned adjacent to the second layer opposite the first layer, the third layer comprising a manifold;
a fourth layer adapted to be positioned adjacent the third layer opposite the second layer, the fourth layer having a plurality of openings and comprising a material adapted to neutralize proteolytic enzymes; and
a fifth layer adapted to be coupled to the fourth layer opposite the third layer, the fifth layer comprising a polymer drape.
65 . (canceled)
66 . (canceled)
67 . (canceled)
68 . A dressing for treating a tissue site, comprising:
a first layer comprising a hydrophobic gel adhesive and a material adapted to neutralize proteolytic enzymes, the first layer having a plurality of apertures;
a second layer comprising a manifold; and
a third layer adapted to be disposed between the first layer and the second layer, the third layer comprising a polymer film having a plurality of fenestrations.
69 . (canceled)
70 . (canceled)
71 . A dressing for treating a tissue site, comprising:
a hydrophobic gel layer;
an enzyme-modulating layer adjacent to the hydrophobic gel layer;
a fluid control layer adjacent to the hydrophobic gel layer opposite the enzyme-modulating layer; and
a manifold layer adjacent the fluid control layer opposite the hydrophobic gel layer, the manifold layer comprising a foam.
72 .- 78 . (canceled)