Continuous crystallization of cannabinoids in a stirred-tank reactor

1. A method for producing crystalline cannabinoid particles in continuous mode, the method comprising:

preparing a cannabinoid-rich solution that comprises a first cannabinoid;

inducing the cannabinoid-rich solution to a supersaturated state in which the first cannabinoid has a supersaturated concentration that is greater than a corresponding saturation concentration of the first cannabinoid;

flowing the cannabinoid-rich solution into a continuous stirred-tank reactor, CSTR, in a continuous manner;

mixing the cannabinoid-rich solution under turbulent mixing conditions to form a plurality of crystalline cannabinoid particles and a cannabinoid-depleted solution within the CSTR;

discharging the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution from the CSTR in a continuous manner to provide a flow rate through the CSTR; and

separating crystalline cannabinoid particles from the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution in a continuous manner,

wherein the turbulent mixing conditions are defined by a Reynolds number that is greater than a critical Reynolds number for the cannabinoid-rich solution and the CSTR.

2. The method of claim 1 , wherein the critical Reynolds is about equal to a Reynolds number above which a power number for the reactor is about constant.

3. The method of claim 1 , wherein the CSTR comprises a baffle that is shaped, oriented, or positioned to redirect flow within the CSTR.

4. The method of claim 3 , wherein the baffle is one of a plurality of baffles.

5. The method of claim 1 , further comprising cooling the cannabinoid-rich solution, the cannabinoid-depleted solution, or a combination thereof within the CSTR.

6. The method of claim 1 , wherein the first cannabinoid is THC (Δ9-THC), THCA, Δ8-THC, trans-Δ10-THC, cis Δ10-THC, THCV, THCVA, Δ8-THCV, Δ9-THCV, CBD, CBDA, CBDV, CBDVA, CBC, CBCA, CBCV, CBCVA, CBG, CBGA, CBGV, CBGVA, CBN, CBNA, CBNV, CBNVA, CBND, CBNDA, CBNDV, CBNDVA, CBE, CBEA, CBEV, CBEVA CBL, CBLA, CBLV, CBLVA, CBT, CBTA, or cannabicitran.

7. The method of claim 1 , wherein the cannabinoid-rich solution comprises a cannabinoid extract, a cannabinoid resin, a cannabinoid distillate, a cannabinoid isolate, or a combination thereof.

8. The method of claim 1 , wherein the cannabinoid-rich solution comprises THC (Δ9-THC), THCA, Δ8-THC, trans-Δ10-THC, cis Δ10-THC, THCV, THCVA, Δ8-THCV, Δ9-THCV, CBD, CBDA, CBDV, CBDVA, CBC, CBCA, CBCV, CBCVA, CBG, CBGA, CBGV, CBGVA, CBN, CBNA, CBNV, CBNVA, CBND, CBNDA, CBNDV, CBNDVA, CBE, CBEA, CBEV, CBEVA CBL, CBLA, CBLV, CBLVA, CBT, CBTA, cannabicitran, or a combination thereof.

9. The method of claim 1 , wherein the cannabinoid-rich solution comprises a solvent, and wherein the solvent comprises pentane, hexane, heptane, methanol, ethanol, isopropanol, dimethyl sulfoxide, acetone, ethyl acetate, diethyl ether, tert-butyl methyl ether, water, acetic acid, anisole, 1-butanol, 2-butanol, butane, butyl acetate, ethyl formate, formic acid, isobutyl acetate, isopropyl acetate, methyl acetate, 3-methyl-1-butanol, methyl ethyl ketone, 2-methyl-1-propanol, 1-pentanol, 1-propanol, propane, propyl acetate, trimethylamine, or a combination thereof.

10. The method of claim 1 , wherein the cannabinoid-rich solution has a viscosity of between about 0.05 cP and about 250 cP at an inlet to the CSTR.

11. The method of claim 1 , wherein the cannabinoid-rich solution has a fluid density of between about 0.2 g/mL and about 1,700 g/mL at an inlet to the CSTR.

12. The method of claim 1 , wherein the cannabinoid-rich solution has a temperature of between about 0° C. and about 80° C. at an inlet to the CSTR.

13. The method of claim 1 , wherein the inducing of the cannabinoid-rich solution to the supersaturated state precedes the mixing of the cannabinoid-rich solution.

14. The method of claim 1 , wherein the inducing of the cannabinoid-rich solution to the supersaturated state is concurrent with the mixing the cannabinoid-rich solution.

15. The method of claim 1 , wherein the cannabinoid-rich solution further comprises an excipient.

16. The method of claim 1 , further comprising dispersing a plurality of seed crystals into the cannabinoid-rich solution concurrent with the mixing the cannabinoid-rich solution.

17. The method of claim 1 , further comprising:

flowing the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution into an additional CSTR;

mixing the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution to form a plurality of larger crystalline cannabinoid particles within the additional CSTR; and

discharging the plurality of larger crystalline cannabinoid particles and the cannabinoid-depleted solution from the additional CSTR in a continuous manner to provide a flow rate through the additional CSTR,

wherein separating crystalline cannabinoid particles from the plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution comprises separating the larger crystalline cannabinoid particles from plurality of crystalline cannabinoid particles and the cannabinoid-depleted solution.

18. The method of claim 1 , wherein the mixing of the cannabinoid-rich solution under the turbulent mixing conditions comprises mixing the cannabinoid-rich solution with an energy dissipation rate that is sufficient to produce eddies with a Kolmogorov length scale that is larger than the size of the crystalline cannabinoid particles.

19. The method of claim 1 , further comprising evaporating the cannabinoid-rich solution, the cannabinoid-depleted solution, or a combination thereof within the CSTR to reduce the volume of the cannabinoid-rich solution, the cannabinoid-depleted solution, or the combination thereof to between 80% and 20% of the initial volume of the cannabinoid-rich solution, the cannabinoid-depleted solution, or the combination thereof.