IP Library Patent Application 17629853
Patent Application
App. No. 17/629,853

MULTIFUNCTIONAL EXTRACTS OF SUGARCANE STRAW OR BAGASSE AND USES THEREOF

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Patent No.
US None
App. No.
17/629,853
Abstract

Provided herein are extracts of sugarcane straw or bagasse, methods of preparing the extracts, and the use of the extracts in compositions that have antioxidant activity, anti-inflammation activity, and antimicrobial activity that can be used as multifunctional ingredients. Further provided are methods of using the extracts to treat or ameliorate conditions involving oxidation, inflammation, skin and food enzymes inhibition activity capacity and microbial growth.

Claims (31)

1 . A method of preparing an extract from sugarcane bagasse or sugarcane straw comprising:

obtaining a dried sugarcane bagasse or a dried sugarcane straw;

milling the dried bagasse or the dried straw;

mixing the milled bagasse or straw with a solution comprising a solvent to form a mixture;

stirring the mixture;

separating a liquid fraction and a solid fraction of the mixture;

concentrating the liquid fraction to obtain an extract; and

optionally drying the liquid fraction to obtain a dry extract.

2 . The method of claim 1 , wherein the bagasse or the straw are dried at a temperature not less than 30° C.

3 . The method of claim 1 , wherein the dried bagasse or the dried straw is milled to a size ranging from 2 mm to 4 mm.

4 . The method of claim 1 , wherein the solvent is selected from the group consisting of: acetone, dichloromethane, ethanol, methanol, and combinations thereof.

5 . The method of claim 1 , wherein the solution comprising the solvent comprises ethanol.

6 . The method of claim 1 , wherein the mixture is stirred for at least 24 hours.

7 . The method of claim 1 , wherein the mixture is stirred at a temperature ranging from 20° C. to 22° C.

8 . The method of claim 1 , wherein the liquid fraction and the solid fraction are separated by filtration.

9 . An extract obtained by the method of claim 1 .

10 . (canceled)

11 . (canceled)

12 . The extract of claim 9 , wherein the extract inhibits or reduces skin enzymes activity.

13 . The extract of claim 9 , comprising from about 2% (wt/wt) to 8% (wt/wt) cellobiose, from about 2% (wt/wt) to 10% glucose (wt/wt), not more than about 2% (wt/wt) xylose, not more than 1% (wt/wt) galactose, not more than 0.1% (wt/wt) arabinose, not more than 15% (wt/wt) fructose, and not more than 6% (wt/wt) mannitol.

14 . The extract of claim 9 , further comprising not more than 4% (wt/wt) malic acid, not more than 5% (wt/wt) succinic acid, and not more than 3% (wt/wt) formic acid.

15 . The extract of claim 9 , further comprising not more than 1% (wt/wt) chlorogenic acid, not more than 1% (wt/wt) trans-5-caffeoylquinic acid, not more than 10% (wt/wt) trans-3-feruloylquinic acid, not more than 1% (wt/wt) feruylquinic acid, not more than 1% (wt/wt) feruylglucaric acid, not more than 1% (wt/wt) p-coumaric acid, not more than 1% (wt/wt) rans-ferulic acid, not more than 1% (wt/wt) diosmetin-6-C-glucoside, not more than 1% (wt/wt) tricin-7-O-glucuronidesulfate, and not more than 1% (wt/wt) pinellic acid.

16 . The extract of claim 9 , further comprising not more than 2% (wt/wt) cellobiose, from about 1% (wt/wt) to 8% (wt/wt) glucose, not more than about 1% (wt/wt) xylose, not more than 2% (wt/wt) arabinose, not more than 12% (wt/wt) fructose, and not more than 6% (wt/wt) mannitol.

17 . The extract of claim 9 , further comprising about 5% (wt/wt) to 12% (wt/wt) malic acid, from about 3% (wt/wt) to about 20% (wt/wt) succinic acid, and not more than 10% (wt/wt) formic acid.

18 . The extract of claim 9 , further comprising not more than 1% (wt/wt) chlorogenic acid, not more than 1% (wt/wt) trans-5-caffeoylquinic acid, not more than 1% (wt/wt) trans-3-feruloylquinic acid, not more than 1% (wt/wt) feruylquinic acid, not more than 1% (wt/wt) feruylglucaric acid, not more than 1% (wt/wt) p-coumaric acid, not more than 1% (wt/wt) trans-ferulic acid, not more than 1% (wt/wt) diosmetin-6-C-glucoside, not more than 1% (wt/wt) tricin-7-O-glucuronidesulfate, and not more than 1% (wt/wt) pinellic acid.

19 . A pharmaceutical or cosmetic composition comprising an active amount of the extract of claim 9 .

20 . The composition of claim 19 , wherein the concentration of the extract is at least 1.25 mg/mL.

21 . The composition of claim 19 , wherein the composition is suitable for topical administration, and further comprises a penetration enhancer.

22 . The composition of claim 19 , further comprising an active agent.

23 . (canceled)

24 . (canceled)

Assignments (6)
SECURITY INTEREST Recorded Aug 17, 2023
From: AMYRIS, INC.; AMYRIS CLEAN BEAUTY, INC.; AMYRIS FUELS, LLC; AB TECHNOLOGIES LLC; APRINNOVA, LLC; AMYRIS-OLINKA, LLC; ONDA BEAUTY INC.; UPLAND 1 LLC; AMYRIS ECO-FAB LLC; CLEAN BEAUTY 4U HOLDINGS, LLC; AMYRIS CLEAN BEAUTY LATAM LTDA; INTERFACES INDUSTRIA E COMERCIA DE COSMETICOS LTDA; AMYRIS BIOTECHNOLOGIA DO BRASIL LTDA; AMYRIS EUROPE TRADING B.V. (NETHERLANDS); AMYRIS BIO PRODCUTS PORTUGAL, UNIPESSOAL, LDA; BEAUTY LABS INTERNATIONAL LIMITED; AMYRIS UK TRADING LIMITED
To: EUAGORE, LLC
Reel/Frame 064619/0778 →
SECURITY INTEREST Recorded Aug 3, 2023
From: AMYRIS CLEAN BEAUTY, INC.; AMYRIS FUELS, LLC; AB TECHNOLOGIES LLC; AMYRIS, INC.
To: MUIRISC, LLC
Reel/Frame 064492/0518 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2022
From: AMYRIS BIO PRODUCTS PORTUGAL, UNIPESSOAL, LDA.
To: UNIVERSIDADE CATÓLICA PORTUGUESA
Reel/Frame 061854/0582 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2022
From: PINTADO, MARIA MANUELA ESTEVEZ; MADUREIRA, ANA RAQUEL MENDES FERREIRA MONTEIRO; OLIVEIRA, ANA LUCIA DA SILVA
To: AMYRIS BIO PRODUCTS PORTUGAL, UNIPESSOAL, LTDA.
Reel/Frame 061815/0286 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2022
From: ESTEVEZ PINTADO, MARIA MANUELA; MENDES FERREIRA MONTEIRO MADUREIRA, ANA RAQUEL; DA SILVA OLIVEIRA, ANA LÚCIA
To: AMYRIS BIO-PRODUCTS PORTUGAL
Reel/Frame 058758/0367 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2022
From: ESTEVEZ PINTADO, MARIA MANUELA; MENDES FERREIRA MONTEIRO MADUREIRA, ANA RAQUEL; DA SILVA OLIVEIRA, ANA LÚCIA
To: UNIVERSIDADE CATÓLICA PORTUGUESA - UCP
Reel/Frame 058758/0577 →