IP Library › Patent Application 17638840

Patent Application Utility PCT National Stage

App. No. 17/638,840 · Confirmation No. 7058

CHARACTERIZING METHYLATED DNA, RNA, AND PROTEINS IN SUBJECTS SUSPECTED OF HAVING LUNG NEOPLASIA

Inventors: Scott Morris, David Mallery, Hatim T. Allawi, Graham P. Lidgard, Maria Giakoumopoulos, Michael W. Kaiser, David A. Ahlquist, William R. Taylor, Douglas W. Mahoney

Applicants: Mayo Foundation for Medical Education and Research, Exact Sciences Corporation

Docketed New Case - Ready for Examination View Publication ↗

	Code	Description	Pages	PDF
2026-07-29	`AMSB`	Amendment Submitted/Entered with Filing of Continued Prosecution Application (CPA)/Request for Continued Examination(RCE)	—	View
2026-07-29	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2026-07-29	`AMSB`	Amendment Submitted/Entered with Filing of Continued Prosecution Application (CPA)/Request for Continued Examination(RCE)	1	View
2026-07-29	`CLM`	Claims	5	View
2026-07-29	`REM`	Applicant Arguments/Remarks Made in an Amendment	4	View
2026-07-29	`RCEX`	Request for Continued Examination (RCE)	3	View
2026-07-29	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2026-07-29	`N417.PYMT`	Electronic Fee Payment	2	View
2026-04-29	`CTFR`	Final Rejection	17	View
2026-04-29	`SRFW`	Search information including classification, databases and other search related notes	3	View
2026-04-29	`1449`	List of References cited by applicant and considered by examiner	4	View
2026-04-29	`SRNT`	Examiner's search strategy and results	13	View
2026-04-29	`1449`	List of References cited by applicant and considered by examiner	4	View
2026-02-11	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2026-02-11	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2026-02-11	`CLM`	Claims	5	View
2026-02-11	`REM`	Applicant Arguments/Remarks Made in an Amendment	5	View
2026-02-11	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2026-02-11	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2026-02-11	`N417.PYMT`	Electronic Fee Payment	2	View
2025-11-14	`CTNF`	Non-Final Rejection	15	View
2025-11-14	`892`	List of references cited by examiner	1	View
2025-11-14	`SRFW`	Search information including classification, databases and other search related notes	3	View
2025-11-14	`SRNT`	Examiner's search strategy and results	11	View
2025-11-14	`SRNT`	Examiner's search strategy and results	1	View
2025-11-14	`1449`	List of References cited by applicant and considered by examiner	4	View
2025-11-06	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2025-11-06	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2025-10-23	`AMSB`	Amendment Submitted/Entered with Filing of Continued Prosecution Application (CPA)/Request for Continued Examination(RCE)	—	View
2025-10-23	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2025-10-23	`FOR`	Foreign Reference	36	View
2025-10-23	`RCEX`	Request for Continued Examination (RCE)	3	View
2025-10-23	`A.NE`	Response After Final Action	1	View
2025-10-23	`CLM`	Claims	5	View
2025-10-23	`REM`	Applicant Arguments/Remarks Made in an Amendment	2	View
2025-10-23	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-10-23	`N417.PYMT`	Electronic Fee Payment	2	View
2025-07-24	`CTFR`	Final Rejection	10	View
2025-07-24	`892`	List of references cited by examiner	1	View
2025-07-24	`SRFW`	Search information including classification, databases and other search related notes	2	View
2025-07-24	`1449`	List of References cited by applicant and considered by examiner	4	View
2025-05-13	`N417.PYMT`	Electronic Fee Payment	2	View
2025-05-13	`FOR`	Foreign Reference	82	View
2025-05-13	`FOR`	Foreign Reference	57	View
2025-05-13	`FOR`	Foreign Reference	59	View
2025-05-13	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2025-05-13	`FOR`	Foreign Reference	28	View
2025-05-13	`FOR`	Foreign Reference	167	View
2025-05-13	`TRAN.LET`	Transmittal Letter	1	View
2025-05-13	`FOR`	Foreign Reference	124	View
2025-05-13	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2025-05-12	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	—	View
2025-05-12	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2025-05-12	`A...`	Amendment/Request for Reconsideration-After Non-Final Rejection	1	View
2025-05-12	`CLM`	Claims	6	View
2025-05-12	`REM`	Applicant Arguments/Remarks Made in an Amendment	8	View
2025-05-12	`WFEE`	Fee Worksheet (SB06)	1	View
2025-02-10	`CTNF`	Non-Final Rejection	14	View
2025-02-10	`892`	List of references cited by examiner	1	View
2025-02-10	`SRFW`	Search information including classification, databases and other search related notes	2	View
2025-02-10	`SRNT`	Examiner's search strategy and results	1	View
2025-02-10	`FOR`	Foreign Reference	29	View
2025-02-10	`1449`	List of References cited by applicant and considered by examiner	4	View
2025-02-10	`FOR`	Foreign Reference	243	View
2025-02-10	`1449`	List of References cited by applicant and considered by examiner	26	View
2025-02-10	`1449`	List of References cited by applicant and considered by examiner	10	View
2025-02-10	`SRNT`	Examiner's search strategy and results	6	View
2025-01-13	`ELC.`	Response to Election / Restriction Filed	—	View
2025-01-13	`FOR`	Foreign Reference	46	View
2025-01-13	`FOR`	Foreign Reference	194	View
2025-01-13	`FOR`	Foreign Reference	225	View
2025-01-13	`FOR`	Foreign Reference	77	View
2025-01-13	`FOR`	Foreign Reference	135	View
2025-01-13	`FOR`	Foreign Reference	122	View
2025-01-13	`N417`	Electronic Filing System Acknowledgment Receipt	11	View
2025-01-13	`FOR`	Foreign Reference	143	View
2025-01-13	`REF.OTHER`	Other reference-Patent/Application/Search Documents	12	View
2025-01-13	`FOR`	Foreign Reference	58	View
2025-01-13	`FOR`	Foreign Reference	132	View
2025-01-13	`FOR`	Foreign Reference	76	View
2025-01-13	`FOR`	Foreign Reference	48	View
2025-01-13	`FOR`	Foreign Reference	34	View
2025-01-13	`FOR`	Foreign Reference	116	View
2025-01-13	`FOR`	Foreign Reference	147	View
2025-01-13	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	10	View
2025-01-13	`FOR`	Foreign Reference	20	View
2025-01-13	`FOR`	Foreign Reference	284	View
2025-01-13	`FOR`	Foreign Reference	91	View
2025-01-13	`FOR`	Foreign Reference	114	View
2025-01-13	`FOR`	Foreign Reference	95	View
2025-01-13	`FOR`	Foreign Reference	31	View
2025-01-13	`FOR`	Foreign Reference	172	View
2025-01-13	`FOR`	Foreign Reference	55	View
2025-01-13	`FOR`	Foreign Reference	86	View
2025-01-13	`FOR`	Foreign Reference	42	View
2025-01-13	`FOR`	Foreign Reference	63	View
2025-01-13	`FOR`	Foreign Reference	107	View
2025-01-13	`FOR`	Foreign Reference	76	View
2025-01-13	`FOR`	Foreign Reference	121	View
2025-01-13	`FOR`	Foreign Reference	53	View
2025-01-13	`FOR`	Foreign Reference	92	View
2025-01-13	`FOR`	Foreign Reference	335	View
2025-01-13	`FOR`	Foreign Reference	84	View
2025-01-13	`FOR`	Foreign Reference	136	View
2025-01-13	`FOR`	Foreign Reference	217	View
2025-01-13	`FOR`	Foreign Reference	75	View
2025-01-13	`FOR`	Foreign Reference	108	View
2025-01-13	`FOR`	Foreign Reference	74	View
2025-01-13	`ELC.`	Response to Election / Restriction Filed	1	View
2025-01-13	`CLM`	Claims	5	View
2025-01-13	`REM`	Applicant Arguments/Remarks Made in an Amendment	1	View
2025-01-13	`FOR`	Foreign Reference	260	View
2025-01-13	`FOR`	Foreign Reference	84	View
2025-01-13	`FOR`	Foreign Reference	38	View
2025-01-13	`WFEE`	Fee Worksheet (SB06)	1	View
2024-11-13	`CTRS`	Requirement for Restriction/Election	8	View
2023-02-03	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2023-02-03	`OATH`	Oath or Declaration filed	6	View
2022-12-22	`NTC.PUB`	Notice of Publication	1	View
2022-12-19	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	4	View
2022-12-19	`FOR`	Foreign Reference	186	View
2022-12-19	`FOR`	Foreign Reference	51	View
2022-12-19	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2022-11-14	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2022-11-14	`R48.REQ.DIS`	Rejection of Request under Rule 48 to correct inventorship or name	1	View
2022-11-14	`M903`	Notice of Designated Office (DO) / Elected Office (EO) Acceptance Mailed	2	View
2022-11-14	`APP.FILE.REC`	Filing Receipt	4	View
2022-11-14	`WFEE`	Fee Worksheet (SB06)	1	View
2022-11-08	`PA..`	Power of Attorney	2	View
2022-11-08	`N417.PYMT`	Electronic Fee Payment	2	View
2022-11-08	`N417`	Electronic Filing System Acknowledgment Receipt	3	View
2022-11-08	`PEFR`	Applicant Response to Pre-Exam Formalities Notice	1	View
2022-11-08	`CLM`	Claims	5	View
2022-11-08	`REM`	Applicant Arguments/Remarks Made in an Amendment	1	View
2022-11-08	`OATH`	Oath or Declaration filed	8	View
2022-11-08	`PEFR`	Applicant Response to Pre-Exam Formalities Notice	—	View
2022-10-11	`IDS`	Information Disclosure Statement (IDS) Form (SB08)	26	View
2022-10-11	`N417`	Electronic Filing System Acknowledgment Receipt	10	View
2022-10-11	`FOR`	Foreign Reference	84	View
2022-10-11	`FOR`	Foreign Reference	31	View
2022-10-11	`FOR`	Foreign Reference	73	View
2022-10-11	`FOR`	Foreign Reference	48	View
2022-10-11	`FOR`	Foreign Reference	171	View
2022-10-11	`FOR`	Foreign Reference	35	View
2022-10-11	`FOR`	Foreign Reference	130	View
2022-10-11	`FOR`	Foreign Reference	38	View
2022-10-11	`FOR`	Foreign Reference	47	View
2022-10-11	`FOR`	Foreign Reference	72	View
2022-10-11	`FOR`	Foreign Reference	67	View
2022-10-11	`FOR`	Foreign Reference	48	View
2022-10-11	`FOR`	Foreign Reference	871	View
2022-10-11	`FOR`	Foreign Reference	55	View
2022-10-11	`FOR`	Foreign Reference	146	View
2022-10-11	`FOR`	Foreign Reference	39	View
2022-10-11	`FOR`	Foreign Reference	165	View
2022-10-11	`FOR`	Foreign Reference	46	View
2022-10-11	`FOR`	Foreign Reference	246	View
2022-10-11	`FOR`	Foreign Reference	172	View
2022-10-11	`FOR`	Foreign Reference	9	View
2022-10-11	`FOR`	Foreign Reference	283	View
2022-10-11	`FOR`	Foreign Reference	76	View
2022-10-11	`FOR`	Foreign Reference	47	View
2022-10-11	`FOR`	Foreign Reference	179	View
2022-10-11	`FOR`	Foreign Reference	30	View
2022-10-11	`FOR`	Foreign Reference	76	View
2022-10-11	`FOR`	Foreign Reference	46	View
2022-10-11	`FOR`	Foreign Reference	49	View
2022-10-11	`FOR`	Foreign Reference	136	View
2022-10-11	`FOR`	Foreign Reference	132	View
2022-10-11	`FOR`	Foreign Reference	32	View
2022-10-11	`FOR`	Foreign Reference	57	View
2022-10-11	`FOR`	Foreign Reference	115	View
2022-10-11	`FOR`	Foreign Reference	83	View
2022-10-11	`FOR`	Foreign Reference	118	View
2022-10-11	`FOR`	Foreign Reference	63	View
2022-10-11	`FOR`	Foreign Reference	244	View
2022-10-11	`FOR`	Foreign Reference	132	View
2022-10-11	`FOR`	Foreign Reference	68	View
2022-10-11	`FOR`	Foreign Reference	268	View
2022-10-11	`N417`	Electronic Filing System Acknowledgment Receipt	10	View
2022-10-11	`N417`	Electronic Filing System Acknowledgment Receipt	5	View
2022-10-11	`N417`	Electronic Filing System Acknowledgment Receipt	10	View
2022-10-11	`REF.OTHER`	Other reference-Patent/Application/Search Documents	11	View
2022-10-11	`REF.OTHER`	Other reference-Patent/Application/Search Documents	17	View
2022-10-11	`REF.OTHER`	Other reference-Patent/Application/Search Documents	17	View
2022-10-11	`REF.OTHER`	Other reference-Patent/Application/Search Documents	20	View
2022-10-11	`REF.OTHER`	Other reference-Patent/Application/Search Documents	12	View
2022-10-11	`REF.OTHER`	Other reference-Patent/Application/Search Documents	12	View
2022-10-11	`N417`	Electronic Filing System Acknowledgment Receipt	10	View
2022-09-07	`WCLM`	Claims Worksheet (PTO-2022)	1	View
2022-09-07	`WFEE`	Fee Worksheet (SB06)	1	View
2022-09-07	`371.FEE.M923`	371 (National Stage) Supplemental Fees Missing - Form M923	2	View
2022-09-07	`APP.FILE.REC`	Filing Receipt	4	View
2022-03-02	`CRFE`	Sequence Listing in Computer Readable Format, No errors found	21	View
2022-02-27	`DRW`	Drawings-only black and white line drawings	96	View
2022-02-27	`CLM`	Claims	13	View
2022-02-27	`SPEC`	Specification	146	View
2022-02-27	`ABST`	Abstract	2	View
2022-02-27	`P.N.101.CONV`	PCT/RO/101 - Request form for new International Application - Conventional	6	View
2022-02-27	`FRPR`	Certified Copy of Foreign Priority Application	77	View
2022-02-27	`TRNA`	Transmittal of New Application	4	View
2022-02-27	`ADS`	Application Data Sheet	11	View
2022-02-27	`WFEE`	Fee Worksheet (SB06)	2	View
2022-02-27	`N417`	Electronic Filing System Acknowledgment Receipt	2	View
2022-02-27	`SEQ.TXT`	Sequence Listing (Text File)	1	View
2022-02-27	`P.306`	PCT/IB/306 - Notification of the Recording of a Change	1	View

Inventors

Scott Morris Phoenix, AZ

David Mallery Phoenix, AZ

Hatim T. Allawi Middleton, WI

Graham P. Lidgard Middleton, WI

Maria Giakoumopoulos Middleton, WI

Michael W. Kaiser Stoughton, WI

David A. Ahlquist Rochester, MN

William R. Taylor Lake City, MN

Douglas W. Mahoney Rochester, MN

Attorneys & Agents of Record

BRIAN BRADLEY Reg. 73951 Agent · CASIMIR JONES, S.C.

DAVID STAPLE Reg. 65903 Attorney · CASIMIR JONES SC

JENNIFER DUKE Reg. 52838 Agent · EXACT SCIENCES

MARIANNE FUIERER Reg. 39983 Attorney · CASIMIR JONES S.C.

PETER SCHLUETER Reg. 67792 Attorney · MICHAEL BEST & FRIEDRICH LLP

ASHLEY HAMLETT Reg. 62569 Agent · EXACT SCIENCES

SAROJINI ADUSUMILLI Reg. 76174 Agent

LISA MUELLER Reg. 38978 Attorney · MICHAEL BEST

CARLY CONWAY Reg. 68978 Attorney · EXACT SCIENCES CORPORATION

ANNE REYNOLDS Reg. 65455 Attorney · CASIMIR JONES, S.C.

THOMAS ISENBARGER Reg. 71476 Attorney · CASIMIR JONES S.C.

TANYA ARENSON Reg. 47391 Agent · CASIMIR JONES, S.C.

KIRK HOGAN Reg. 65033 Attorney · CASIMIR JONES S.C.

TRISTAN FUIERER Reg. 52926 Attorney · CASIMIR JONES, S.C.

RICKI ABEGGLEN Reg. 47371 Attorney · RICK ABEGGLEN ATTORNEY

KELLY BARTON Reg. 78227 Agent · CASIMIR JONES, S.C.

THOMAS LYNEIS Reg. 80602 Attorney · GODFREY & KAHN, S.C.

BRADLEY LOREN Reg. 82885 Attorney · MCANDREWS, HELD & MALLOY

RIKKI HULLINGER Reg. 77414 Agent · MICHAEL BEST & FRIEDRICH LLP

JEFFREY CHILDERS Reg. 58126 Attorney · CASIMIR JONES, S.C.

JASON BOND Reg. 45439 Attorney · CASIMIR JONES, S.C.

MARY ANN BROW Reg. 42363 Attorney · CASIMIR JONES, S.C.

DAVID CASIMIR Reg. 42395 Attorney · CASIMIR JONES, S.C.

ROBERT GOETZ Reg. 55210 Attorney · CASIMIR JONES, SC

QIMING DENG Reg. 74051 Attorney · EXACT SCIENCES CORPORATION

JOHN JONES Reg. 44174 Attorney · CASIMIR JONES S.C.

TYLER SISK Reg. 59850 Attorney · CASIMIR JONES S.C.

Classification

USPC 435/6.14

C12Q1/6886 C12Q1/6806 C12Q1/6858 C12Q2600/154 C12Q2600/158 C12Q2600/16

Prosecution

Examiner: BUCHANAN, BAILEY CHEYENNE
Art Unit: 1682
Customer No.: 173254
Docket No.: EXCTD-38699.252
Confirmation No.: 7058

Publication

Pub. No.: US20220403471A1
Pub. Date: 2022-12-22

EXACT SCIENCES CORPORATION

from JPMORGAN CHASE BANK, N.A.

TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENT RIGHTS (REEL/FRAME 69898/0249) Recorded 2026-03-27

075288/0393 →

JPMORGAN CHASE BANK, N.A.

from EXACT SCIENCES CORPORATION

PATENT SECURITY AGREEMENT Recorded 2025-01-14

069898/0249 →

MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

from MAHONEY, DOUGLAS W., TAYLOR, WILLIAM R, ALQUIST, DAVID A

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded 2022-12-06

061998/0826 →

EXACT SCIENCES DEVELOPMENT COMPANY, LLC

from ALLAWI, HATIM T., GIAKOUMOPOULOS, MARIA, LIDGARD, GRAHAM P., KAISER, MICHAEL W., MALLERY, DAVID, MORRIS, SCOTT

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded 2022-12-06

061999/0046 →

EXACT SCIENCES CORPORATION

from EXACT SCIENCES DEVELOPMENT COMPANY, LLC

MERGER Recorded 2022-12-06

061999/0105 →

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this application's details

Quick Facts

App. No.: 17/638,840
Filed: 2022-02-27
Pub. No.: US20220403471A1
Examiner: BUCHANAN, BAILEY CHEYENNE
Art Unit: 1682

External Links

USPTO Patent Center↗ Pre-Grant Publication PDF↗