Systems and methods for applying media to skin

1. A method for treating a targeted tissue of a subject, comprising:

applying a negative pressure to a distal tip of an applicator wherein the distal tip comprises a periphery surrounding a negative pressure surface located on at least one rolling member that rotates in the periphery;

contacting the targeted tissue with the distal tip to form a seal around the periphery wherein the negative pressure surface is configured to apply the negative pressure to the targeted tissue at a plurality of discrete locations within the periphery;

applying a treatment media to the targeted tissue; and

moving the distal tip in contact with the targeted tissue while drawing negative pressure such that moving the distal tip causes transient application of negative pressure on the targeted tissue.

2. The method of claim 1 , wherein a portion of the at least one rolling member extends distally to the periphery of the distal tip such that the at least one rolling member can roll against the targeted tissue.

3. The method of claim 2 , wherein the at least one rolling member comprises a plurality of bores extending through the at least one rolling member such that the negative pressure passes to the targeted tissue through the plurality of bores.

4. The method of claim 2 , wherein the at least one rolling member comprises a plurality of surface discontinuities such that the negative pressure passes to the targeted tissue through the plurality of surface discontinuities.

5. The method of claim 2 , wherein applying the negative pressure to the targeted tissue comprises applying the negative pressure at an interface of the at least one rolling member and the periphery.

6. The method of claim 1 , wherein applying the negative pressure comprises pulsing the negative pressure.

7. The method of claim 1 , wherein applying the negative pressure comprises coupling a remote vacuum source to the applicator.

8. The method of claim 1 , wherein applying the treatment media comprises delivering the treatment media from a remote fluid source.

9. The method of claim 1 , wherein the negative pressure surface is located on a receiving space positioned radially inward from the periphery and within the distal tip and where applying the negative pressure occurs in the receiving space.

10. The method of claim 8 , wherein the negative pressure surface comprises a plurality of channels or discontinuities.

11. The method of claim 1 , wherein the periphery comprises a resilient material.

12. The method of claim 1 , further comprising illuminating the targeted tissue with a light energy using the applicator.

13. The method of claim 1 , further comprising delivering ultrasonic energy to the targeted tissue with the applicator.

14. The method of claim 1 , wherein drawing negative pressure results in the treatment media being entrained in outflows through the applicator from the targeted tissue.

15. The method of claim 14 , further comprising capturing entrained treatment media from an outflow.

16. The method of claim 1 , wherein applying the treatment media comprises causing a flow of fluid through at least one opening in the distal tip of the applicator.

17. The method of claim 12 , wherein the applicator carries a reservoir of the treatment media.

18. A device for treatment of a targeted tissue using a liquid media, the device comprising:

an applicator body having a distal applicator tip;

a liquid media source;

a negative pressure source configured to pull a negative pressure in the applicator body; and

at least one rolling member rotatably exposed at the distal applicator tip, the at least one rolling member disposed in a receiving space in the distal applicator tip and having a plurality of bores extending through the at least one rolling member that allow for application of the negative pressure to the targeted tissue through the at least one rolling member.

19. The device of claim 18 , wherein the plurality of bores are spaced to create a plurality of spaced apart negative pressure regions in the targeted tissue within the periphery when the distal applicator tip forms a seal against the targeted tissue.

20. The device of claim 18 , wherein the negative pressure source comprises a pump carried in the applicator body.

21. The device of claim 18 , wherein the negative pressure source comprises a remote pump coupled to the applicator body and an outflow path by flexible tubing.

22. The device of claim 18 , wherein further comprising a collector in an outflow path adapted to capture liquid media from a flow therein.

23. The device of claim 22 , wherein the collector comprises structure selected from a group consisting of a filter, a baffle arrangement, a cyclonic mechanism and a combination thereof.

24. The device of claim 18 , wherein the liquid media source comprises a reservoir carried in the applicator body.

25. The device of claim 18 , wherein the liquid media source comprises a remote reservoir coupled to the applicator body and an inflow path by flexible tubing.

26. The device of claim 18 , further comprising at least one LED configured to apply light energy to the targeted tissue.

27. The device of claim 18 , further comprising at least one ultrasound emitter coupled to the applicator body and configured to apply ultrasound energy to the targeted skin.

28. A method for treating a targeted tissue of a subject, comprising:

applying a negative pressure to a distal tip of an applicator having a plurality of rolling members, wherein the distal tip comprises a periphery surrounding a negative pressure surface;

contacting the targeted tissue with the distal tip to form a seal around the periphery wherein the negative pressure surface is configured to apply the negative pressure to the targeted tissue at a plurality of discrete locations within the periphery;

applying a treatment media to the targeted tissue; and

moving the distal tip in contact with the targeted tissue while drawing negative pressure.