Fibrous constructs with therapeutic material particles
Sheets of material used in medical devices and filters are disclosed. The sheets may include a fibrous mat including a plurality of microfibers. The microfibers may include a polymer matrix and a plurality of additive particles. The additive particles may include carbon material particles, therapeutic micro particles, and any combination thereof. Medical devices and filters that use the sheets are disclosed. Methods of producing the sheets are also disclosed.
1. A fibrous sheet, comprising:
a mat of fibers comprising a plurality of fibers forming a porous microstructure, wherein the plurality of fibers are formulated from a polymer matrix with a plurality of therapeutic micro or nano particles dispersed throughout the polymer matrix,
wherein the plurality of therapeutic micro or nano particles are not eluded into a surrounding environment,
wherein the plurality of therapeutic micro or nano particles comprise a plurality of carbon material particles,
wherein each of the plurality of carbon material particles are larger than a diameter of each fiber of the mat of fibers, and
wherein each of the plurality of carbon material particles are entangled by the plurality of fibers.
2. The fibrous sheet of claim 1 , wherein the plurality of fibers are formed by an extrusion process.
3. The fibrous sheet of claim 2 , wherein the extrusion process includes any one of rotational spinning, electrospinning, and pressure extrusion and stretching.
4. The fibrous sheet of claim 1 , wherein the carbon material particles comprise any one of graphene nanosheets, graphene quantum dots, graphene nanoribbons, graphene nanoparticles, graphene oxide, pyrolytic carbon, carbon nanofibers, carbon nanotubes, fullerenes, and any combination thereof.
5. The fibrous sheet of claim 1 , wherein each one of the plurality of carbon material particles has a maximum dimension of less than 0.159 mm.
6. The fibrous sheet of claim 1 , wherein the therapeutic micro or nano particles comprise any one of elemental metal, metal oxide, metal colloidal, pyrolytic carbon, poly paraphenylene terephthalamide, polyamid, potassium ferrate, and calcium phosphate.
7. The fibrous sheet of claim 1 , wherein the plurality of carbon material particles are exposed at a surface of fibers of the plurality of fibers.
8. The fibrous sheet of claim 1 , wherein the plurality of carbon material particles completely cover a surface of fibers of the plurality of fibers.
9. A fibrous sheet, comprising:
a mat of fibers, wherein the fibers comprise a polymer matrix and a plurality of carbon material particles that are not eluded into a surrounding environment,
wherein each of the plurality of carbon material particles are larger than a diameter of fibers, and
wherein each of the plurality of carbon material particles are entangled by the fibers.
10. The fibrous sheet of claim 9 , wherein the fibers are formed by an extrusion process.
11. The fibrous sheet of claim 10 , wherein the extrusion process includes any one of rotational spinning, electrospinning, and pressure extrusion and stretching.
12. The fibrous sheet of claim 9 , wherein the polymer matrix comprises any one of polytetrafluoroethylene (PTFE), nylon 6-6, poly paraphenylene terephthalamide, polyurethane, polyethylene, polyester, and polypropylene.
13. A method of forming a fibrous sheet, comprising:
obtaining a polymeric mixture comprising a polymer and a plurality of therapeutic micro or nano particles, wherein the plurality of therapeutic micro or nano particles comprise a plurality of carbon material particles;
extruding the polymeric mixture to form a fibrous mat comprising a plurality of fibers; and sintering the fibrous mat,
wherein the plurality of therapeutic micro or nano particles are configured to not elude into a surrounding environment,
wherein each of the plurality of carbon material particles are larger than a diameter of fibers, and
wherein each of the plurality of carbon material particles are entangled by the fibers.
14. The method of claim 13 , wherein each one of the plurality of therapeutic micro or nano particles has a maximum dimension of less than 0.159 mm.
15. The method of claim 13 , wherein the extruding the polymeric mixture comprises rotational spinning.
16. The method of claim 13 , wherein the extruding the polymeric mixture comprises electrospinning.
17. The method of claim 13 , wherein the extruding the polymeric mixture comprises pressure extruding and stretching.
18. The method of claim 13 , wherein the sintering temperature is ranges from 370° C. to 390° C.
19. The method of claim 13 , wherein the sintering temperature ranges from 360° C. to 400° C.
20. The method of claim 13 , wherein the plurality of fibers are any one of microfibers, nanofibers, and a combination of microfibers and nanofibers.