Granted Patent
B2
US 11,807,874 · App. 17/672,542 · Granted Nov 7, 2023
P450-BM3 variants with improved activity
Inventors:
Robert Osborne (Raleigh, NC); Vesna Mitchell (Santa Clara, CA); Khin Yu Naing Htwe (Daly City, CA); Xiyun Zhang (Fremont, CA); Erika M. Milczek (New York, NY); Jeffrey C. Moore (Westfield, NJ)
Assignee:
Codexis, Inc.
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Abstract
The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
Claims (3)
1. A recombinant cytochrome P450-BM3 variant comprising the amino acid sequence of SEQ ID NO: 54, wherein said recombinant cytochrome P450-BM3 variant has cytochrome P450-BM3 activity.
2. The recombinant cytochrome P450-BM3 variant of claim 1 , wherein said variant oxidizes at least three organic substrates.
3. The recombinant cytochrome P450-BM3 variant of claim 2 , wherein the at least three organic substrates are selected from the group consisting of nifedipine, propranolol, verapamil, and diclofenac.
Assignments (1)
SECURITY INTEREST
Recorded Feb 15, 2024
From: CODEXIS, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT
Reel/Frame 066600/0650 →
Continuity (6)
Provisional Application
62022442
· Jul 9, 2014
Cited By (1)