IP Library Granted Patent US 12,139,494
Granted Patent B2
US 12,139,494 · App. 17/683,146 · Granted Nov 12, 2024

Morphic forms of G1T38 and methods of manufacture thereof

Inventors: Alexander Smith (Apex, NC); Hannah S. White (Chapel Hill, NC); Patricia Andres (Bend, OR); Xufeng Sun (Albany, NY); Lei Zhu (Schenectady, NY); Petinka I. Vlahova (West Lafayette, IN)
C07D487/14A61K45/06C07B2200/13
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Quick Facts
Patent No.
US 12,139,494
App. No.
17/683,146
Granted
Nov 12, 2024
Kind
B2
Abstract

This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of for advantageous therapeutic pharmaceutical efficacy and dosage form stability.

Claims (2)

1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient for solid dosage delivery and between about 10 mg and about 1,000 mg of an isolated crystalline Form B of the di-HCl salt of structure:

characterized by an X-ray powder diffraction (XRPD) pattern comprising at least three 2θ values selected from 6.5±0.2°, 9.5±0.4°, 14.0±0.2°, 14.4±0.2°, 18.1±0.2°, 19.3±0.2°, 19.9±0.2°, and 22.4±0.2°.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2024
From: G1 THERAPEUTICS, INC.
To: PHARMACOSMOS A/S
Reel/Frame 069502/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 5, 2024
From: PHARMACOSMOS A/S
To: PHARMACOSMOS HOLDING A/S
Reel/Frame 069502/0010 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 12, 2024
From: SMITH, ALEXANDER; WHITE, HANNAH S.
To: G1 THERAPEUTICS, INC.
Reel/Frame 069237/0011 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 12, 2024
From: ANDRES, PATRICIA; SUN, XUFENG; ZHU, LEI; VLAHOVA, PETINKA I.
To: ALBANY MOLECULAR RESEARCH
Reel/Frame 069237/0078 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 12, 2024
From: ALBANY MOLECULAR RESEARCH, INC.
To: G1 THERAPEUTICS, INC.
Reel/Frame 069237/0086 →
Continuity (4)
Continuation 16721631 · Dec 19, 2019
Continuation PCTUS2018040435 · Jun 29, 2018
Provisional Application 62526937 · Jun 29, 2017
Related Publication 20230043305A1 · Feb 9, 2023
Cited By (3)
US 12,479,855 US 12,497,404 US 12,527,798