Granted Patent B2

US 12,560,598 · App. 17/683,694 · Granted Feb 24, 2026

Inventor: Newton Howard (Washington, DC)

Assignee: Genesis Intelligence, LLC

G01N33/54333G01N15/06G01N33/533G01N15/01G01N2015/0681G01N2015/0687G01N15/075G01N2333/165G01N2469/10G01N2469/20

Abstract

Claims (27)

1 . An apparatus comprising:

a loading bay disposed on the apparatus to receive a cartridge comprising a plurality of blister reservoirs;

a door disposed on the apparatus to cover the loading bay;

a plurality of blunt prongs disposed on an interior of the door to provide actuation force to the plurality of hermetically sealed blister reservoirs disposed on the cartridge when the door is closed, to directly depress each of the plurality of blister reservoirs so as dispense contents of the plurality of blister reservoirs into chambers of the cartridge associated with each blister reservoir; and

a device disposed relative to the cartridge to move at least a portion of contents of the cartridge among chambers of the cartridge, including chambers of the cartridge associated with each blister reservoir.

2 . The apparatus of claim 1 , wherein the device disposed relative to the cartridge to move at least a portion of the contents of the cartridge among chambers of the cartridge comprises:

a motor having disposed on a drive shaft thereof a pinion;

a rack meshed with the pinion; and

a magnetic device disposed on the pinion and disposed relative to the cartridge so as to move at least a portion of the contents of the cartridge among chambers of the cartridge when the motor is driven.

3 . The apparatus of claim 2 , wherein the magnetic device comprises a permanent magnet or a magnetic coil.

4 . The apparatus of claim 3 , wherein a portion of the contents of the cartridge comprises magnetic beads.

5 . The apparatus of claim 2 , wherein the apparatus further comprises a computer system comprising a processor, memory to store program instructions and data and accessible by the processor, and program instructions stored in the memory and executable by the processor to control driving of the motor.

6 . The apparatus of claim 5 , wherein the cartridge comprises:

a first chamber configured to receive a test sample including a target substance, the first chamber pre-filled with micromagnetic particles treated so as to bind to the target substance; and

a first reservoir pre-filled with reagent labeled with a fluorescent compound, the reagent adapted to bind to treated micromagnetic particles that are bound to the target substance.

7 . The apparatus of claim 6 , wherein the program instructions comprise program instructions to cause the computer system to drive the motor so as to:

mix the treated micromagnetic particles with the test sample by moving the micromagnetic particles, so as to facilitate binding of the treated micromagnetic particles to the target substance; and

mix the treated micromagnetic particles with the reagent labeled with a fluorescent compound, so as to facilitate binding to the treated micromagnetic particles bound to the target substance.

8 . The apparatus of claim 7 , wherein the cartridge further comprises a detection region.

9 . The apparatus of claim 8 , wherein the program instructions further comprise program instructions to cause the computer system to drive the motor so as to:

move the micromagnetic particles to the detection region after the reagent labeled with a fluorescent compound have bound to the treated micromagnetic particles bound to the target substance.

10 . The apparatus of claim 9 , further comprising circuitry configured to detect fluorescence of the fluorescent compound disposed relative to the detection region of the cartridge.

11 . The apparatus of claim 10 , wherein the circuitry configured to detect fluorescence of the fluorescent compound comprises:

at least one excitation light emitting diode arranged to illuminate the detection region so as to excite fluorescence of the fluorescent compound; and

at least one photodiode arranged to detect the excited fluorescence of the fluorescent compound in the detection region and to output a signal representing the detected fluorescence.

12 . The apparatus of claim 11 , wherein the processor is configured to receive the signal representing the detected fluorescence and the program instructions stored in the memory further include program instructions configured to determine presence of the target substance based on the received signal.

13 . The apparatus of claim 12 , further comprising a display configured to display presence of the target substance, wherein the display is connected to the processor, and the program instructions stored in the memory further include program instructions configured to control the display based on the determined presence of the target substance.

Assignments (1)

Continuity (9)

References Cited (103)