METHODS OF USING RIFAMYCIN SV FOR THE TREATMENT OF SICKLE CELL DISEASE
Provided herein is the use of rifamycin SV the treatment of sickle cell disease (SCD).
1 . A method of treating sickle cell disease (SCD) in a patient in need thereof comprising administering at least one rifamycin SV composition to the patient.
2 . A method of reducing elevated levels of circulating aged neutrophils (CANs) in a patient in need thereof comprising administering at least one rifamycin SV composition to the patient.
3 . A method of treating vaso-occlusive crises (VOCs) in a patient in need thereof comprising administering at least one rifamycin SV composition to the patient.
4 . The method according to claim 1 , wherein the at least one rifamycin SV composition comprises a solid dosage form.
5 . The method according to claim 1 , wherein the at least one rifamycin SV composition is an oral composition.
6 . The method according to claim 1 , wherein the at least one rifamycin SV composition is formulated for extended release, delayed release, or both extended and delayed release.
7 . The method according to claim 1 , wherein the at least one rifamycin SV composition is formulated to release substantially in the small intestine.
8 . The method according to claim 1 , wherein the at least one rifamycin SV composition is formulated to release the rifamycin SV substantially following passage of the solid dosage form into the pylorus passage in the proximal part of the intestine.
9 . The method according to claim 1 , wherein the at least one rifamycin SV composition further comprises one or more of a lipophilic compound, a hydrophilic compound, and an amphiphilic compound.
10 . The method according to claim 1 , wherein the at least one rifamycin SV composition further comprises a gastro-resistant coating.
11 . The method according to claim 1 , wherein the at least one rifamycin SV composition is released from the solid dosage form when the solid dosage form is placed in an aqueous medium having a pH in the range of about pH 5 to about pH 7.5.
12 . The method according to claim 1 , wherein the solid dosage form comprises a core and a gastro-resistant coating covering the core.
13 . The method according to claim 1 , wherein administration of the at least one rifamycin SV composition produces a t max,0-24 of the rifamycin SV in the plasma of the subject of about 9.50 hours.
14 . The method according to claim 1 , wherein administration of the at least one rifamycin SV composition produces a C max,0-6 of the rifamycin SV in the plasma of the subject of about 2.30±2.14 ng/mL.
15 . The method according to claim 1 , wherein administration of the at least one rifamycin SV composition produces a C max,0-24 of the rifamycin SV in the plasma of the subject of about 6.23±4.52 ng/mL.
16 . The method according to claim 1 , wherein administration of the at least one rifamycin SV composition produces an AUC 0-6 of the rifamycin SV in the plasma of the subject of about 3.34±2.96 (ng)(h)/mL.
17 . The method according to claim 1 , wherein administration of the at least one rifamycin SV composition produces an AUC 0-24 of the rifamycin SV in the plasma of the subject of about 947.92±20.24 (ng)(h)/ml.
18 . The method according to claim 1 , wherein administration comprise a urine elimination rate of the rifamycin SV in a subject to which the composition is administered of not more than 1% of the total amount of rifamycin SV administered to the subject.
19 . (canceled)