Preservative-free contact lens treating solution comprising hyaluronic acid and erythritol
A preservative-free contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers.
1. A preservative-free contact lens treating solution, comprising consisting of:
(a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof;
(b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol;
(c) one or more nonionic surfactants;
(d) one or more of sodium chloride and potassium chloride;
(e) one or more buffers selected from the group consisting of boric acid, a salt of boric acid and combinations thereof;
(f) one or more lubricants; and
(g) water.
2. The preservative-free contact lens treating solution of claim 1 , consisting of:
(a) about 0.01 to about 0.2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; and
(b) about 0.05 to about 0.5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol.
3. The preservative-free contact lens treating solution of claim 1 , wherein the one or more nonionic surfactants comprise one or more of a poloxamer and a poloxamine.
4. The preservative-free contact lens treating solution of claim 1 , consisting of:
about 0.05 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more nonionic surfactants;
about 0.01 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more of sodium chloride and potassium chloride; and
about 0.1 to about 10% (w/w) of the one or more buffers.
5. The preservative-free contact lens treating solution of claim 1 , wherein the one or more lubricants are glycerol.
6. The preservative-free contact lens treating solution of claim 1 , consisting of about 0.01 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more lubricants.
7. The preservative-free contact lens treating solution of claim 1 , in the form of eye drops.
8. A method of rewetting a contact lens, the method consisting of:
administering a preservative-free contact lens treating solution to a contact lens while worn on the eye, wherein the preservative-free contact lens treating solution consists of (a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) one or more of sodium chloride and potassium chloride; (e) one or more buffers; (f) one or more lubricants; and (g) water.
9. The method of claim 8 , wherein the preservative-free contact lens treating solution consists of:
about 0.05 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more nonionic surfactants;
about 0.01 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more of sodium chloride and potassium chloride; and
about 0.1 to about 10% (w/w) of the one or more buffers.
10. The method of claim 8 , wherein the one or more lubricants are glycerol.
11. The method of claim 9 , wherein the preservative-free contact lens treating solution consists of about 0.01 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more lubricants.
12. The method of claim 8 , wherein the preservative-free contact lens treating solution is in the form of eye drops.
13. A system useful as an artificial tear or for rewetting or lubricating contact lenses while in the eye, the system including at least a drop dispenser capable of holding between about 1 and about 30 ml of a preservative-free contact lens treating solution that consists of (a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) one or more of sodium chloride and potassium chloride; (e) one or more buffers; (f) one or more lubricants; and (g) water.
14. The system of claim 13 , wherein the preservative-free contact lens treating solution consists of:
about 0.05 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more nonionic surfactants;
about 0.01 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more of sodium chloride and potassium chloride; and
about 0.1 to about 10% (w/w) of the one or more buffers.
15. The system of claim 13 , wherein the one or more nonionic surfactants comprise one or more of a poloxamer and a poloxamine.
16. The system of claim 13 , wherein the preservative-free contact lens treating solution consists of:
about 0.05 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more nonionic surfactants;
about 0.01 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more of sodium chloride and potassium chloride;
about 0.1 to about 10% (w/w) of the one or more buffers; and
about 0.01 to about 5 wt. %, based on the total weight of the preservative-free contact lens treating solution, of the one or more lubricants.
17. The system of claim 13 , wherein the preservative-free contact lens treating solution consists of about 0.01 to about 5 wt. %, based on the total weight of the preservative- free contact lens treating solution, of the one or more lubricants.
18. The system of claim 13 , wherein the preservative-free contact lens treating solution is in the form of eye drops.
19. The system of claim 13 , wherein the one or more lubricants are glycerol.