IP Library Patent Application 17691915
Patent Application
App. No. 17/691,915

STIMULATION SYSTEM

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Quick Facts
Patent No.
US None
App. No.
17/691,915
Abstract

A method for detecting and identifying a patient physiological response includes stimulating, via a stimulating electrode coupled to a patient, one or more nerves of the patient. The method includes recording, via a recording electrode coupled to the patient, a plurality of resultant electrical waveforms. The method includes determining, based on the plurality of resultant electrical waveforms, whether at least a subset of the plurality of resultant electrical waveforms includes a patient physiological response. The determining includes comparing the subset of resultant electrical waveforms of the plurality of resultant electrical waveforms to a model waveform from a database of a plurality of model waveforms. The determining includes determining, based on the comparison, a comparison feature. The comparison feature indicates whether the patient physiological response exists in the subset. The method includes displaying, via a display, an indication that the patient physiological response exists in the subset of resultant electrical waveforms.

Claims (34)

1 . A stimulation system for detecting and identifying a patient physiological response, the stimulation system comprising:

at least one processor; and

at least one memory storing instructions which, when executed by the at least one data processor, result in operations comprising:

stimulating, via a stimulating electrode coupled to a patient, one or more nerves of the patient;

recording, via a recording electrode coupled to the patient, a plurality of resultant electrical waveforms;

determining, based on the plurality of resultant electrical waveforms, whether at least a subset of the plurality of resultant electrical waveforms includes a patient physiological response, the determining comprising:

comparing the subset of resultant electrical waveforms of the plurality of resultant electrical waveforms to a model waveform from a database of a plurality of model waveforms; and

determining, based on the comparison, a comparison feature, the comparison feature indicating whether the patient physiological response exists in the subset of resultant electrical waveforms; and

displaying, via a display, an indication when the patient physiological response exists in the subset of resultant electrical waveforms.

2 . The system of claim 1 , wherein the model waveform comprises a predicted physiological response and an ensemble average of a plurality of artifact signals.

3 . The system of claim 2 , wherein the comparison feature further indicates whether an artifact signal exists in the subset of resultant electrical waveforms, the artifact signal generated by noise.

4 . The system of claim 3 , wherein the operations further comprise: displaying, via the display, an indication that the artifact signal exists in the subset of resultant electrical waveforms.

5 . The system of claim 1 , wherein the determining whether at least the subset of the plurality of resultant electrical waveforms includes the patient physiological response further comprises: labeling, based on the comparison feature, the subset of the plurality of resultant electrical waveforms with a positive label or a negative label, the positive label indicating that the patient physiological response exists, and the negative label indicating that the patient physiological response does not exist.

6 . The system of claim 1 , wherein the determination of whether the plurality of resultant electrical waveforms includes the patient physiological response further comprises: determining that the patient physiological response exists when the comparison feature of the subset of electrical waveforms is within a threshold range of a threshold value of the comparison feature.

7 . The system of claim 6 , wherein the comparison feature comprises one or more of a means squared error between the subset of resultant electrical waveforms and the model waveform, a correlation between the subset of resultant electrical waveforms and the model waveform, a physiological coefficient amplitude, a power of fundamental harmonic noise, a THP of higher harmonic noise, a ratio of a physiological coefficient of the subset of resultant electrical waveforms to a power of the harmonic noise, and a ratio of variance of the patient physiological response of the subset of resultant electrical waveforms to the predicted physiological response of the model.

8 . The system of claim 1 , wherein the determination of whether the plurality of resultant electrical waveforms includes the patient physiological response further comprises: determining that the patient physiological response exists when a polarity of each electrical waveform of the subset of resultant electrical waveforms is the same.

9 . The system of claim 1 , wherein the comparison feature represents a comparison of a morphology of the subset of resultant electrical waveforms to a morphology of the model waveform.

10 . The system of claim 5 , wherein the comparison feature comprises a plurality of comparison features, and wherein the labeling is further based on a mathematical representation of the plurality of comparison features.

11 . The system of claim 5 , wherein the labeling comprises comparing the comparison feature to a plurality of previously generated comparison features.

12 . The system of claim 1 , wherein the subset of the plurality of resultant electrical waveforms are time-locked.

13 . The system of claim 1 , wherein the stimulating comprises transmitting a plurality of electrical stimuli; and wherein the stimulating electrode is in communication with an evoked potential detection device configured to monitor the one or more peripheral nerves of the patient.

14 . The system of claim 13 , wherein the plurality of resultant electrical waveforms is received by the evoked potential detection device, the resultant electrical waveforms generated by the patient in response to the electrical stimuli.

15 . A method for detecting and identifying a patient physiological response, the method comprising:

stimulating, via a stimulating electrode coupled to a patient, one or more nerves of the patient;

recording, via a recording electrode coupled to the patient, a plurality of resultant electrical waveforms;

determining, based on the plurality of resultant electrical waveforms, whether at least a subset of the plurality of resultant electrical waveforms includes a patient physiological response, the determining comprising:

comparing the subset of resultant electrical waveforms of the plurality of resultant electrical waveforms to a model waveform from a database of a plurality of model waveforms; and

determining, based on the comparison, a comparison feature, the comparison feature indicating whether the patient physiological response exists in the subset of resultant electrical waveforms; and

displaying, via a display, an indication that the patient physiological response exists in the subset of resultant electrical waveforms.

16 . The method of claim 15 , wherein the model waveform comprises a predicted physiological response and an ensemble average of a plurality of artifact signals.

17 . The method of claim 16 , wherein the comparison feature further indicates whether an artifact signal exists in the subset of resultant electrical waveforms.

18 . The method of claim 17 , further comprising: displaying, via the display, an indication that the artifact signal exists in the subset of resultant electrical waveforms.

19 . The method of claim 15 , wherein the determining whether at least the subset of the plurality of resultant electrical waveforms includes the patient physiological response further comprises: labeling, based on the comparison feature, the subset of the plurality of resultant electrical waveforms with a positive label or a negative label, the positive label indicating that the patient physiological response exists, and the negative label indicating that the patient physiological response does not exist.

20 . The method of claim 15 , wherein the determination of whether the plurality of resultant electrical waveforms includes the patient physiological response further comprises: determining that the patient physiological response exists when the comparison feature of the subset of electrical waveforms is within a threshold range of a threshold value of the comparison feature.

Assignments (6)
CONFIRMATORY GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded May 12, 2026
From: ALPHATEC SPINE, INC.; SAFEOP SURGICAL, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 075560/0884 →
RELEASE OF PATENT SECURITY INTEREST AT REEL/FRAME NO. 62681/0020 Recorded May 1, 2026
From: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
To: ALPHATEC SPINE, INC.; SAFEOP SURGICAL, INC.
Reel/Frame 075385/0575 →
RELEASE OF SECURITY INTEREST IN PATENT COLLATERAL AT REEL/FRAME NO. 62310/0001 Recorded May 1, 2026
From: MIDCAP FUNDING IV TRUST, AS AGENT
To: ALPHATEC SPINE, INC.; SAFEOP SURGICAL, INC.
Reel/Frame 075316/0001 →
SECURITY INTEREST Recorded Feb 7, 2023
From: ALPHATEC SPINE, INC.; SAFEOP SURGICAL, INC.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION
Reel/Frame 062681/0020 →
SECURITY INTEREST Recorded Jan 6, 2023
From: ALPHATEC SPINE, INC.; SAFEOP SURGICAL, INC.
To: MIDCAP FUNDING IV TRUST
Reel/Frame 062310/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 10, 2022
From: CLEVELAND, DANIEL MILTON; JOHNS, GREGG; O'BRIEN, RICHARD ARTHUR; SNOW, ROBERT GERARD
To: ALPHATEC SPINE, INC.
Reel/Frame 059229/0634 →