Bioerodible drug delivery devices
This invention relates to a bioerodible drug delivery device that can be implanted in a patient at or near an area in need of treatment. The bioerodible drug delivery device can be used to deliver a wide variety of different pharmaceutically active agents, and can do so at a controlled rate and over an extended period of time. The bioerodible drug delivery device includes a bioerodible polymeric outer housing with one or more delivery ports for delivering the pharmaceutically active agent(s) contained therein. The polymer used as the bioerodible polymeric outer housing is not substantially degraded during the dosing of the pharmaceutically active agent(s) in the bioerodible drug delivery device. The invention also provides methods of making the bioerodible drug delivery device and using it for the treatment of diseases and disorders.
1. A method of treating an eye disease or disorder in a patient, the method comprising
identifying an area of a patient's eye in need of treatment;
implanting a bioerodible drug delivery device in sufficient proximity to the area in need of treatment to provide therapeutic relief, wherein the bioerodible drug delivery device comprises
a bioerodible drug core comprising a pharmaceutically active agent and polyvinyl alcohol,
a bioerodible outer member that substantially surrounds the drug core, wherein the bioerodible outer member comprises poly(lactic-co-glycolic) acid (PLGA) where lactic acid/glycolic acid is present in a molar ratio ranging from and including 82:18 to 85:15; and
at least one delivery port that is permeable to the pharmaceutically active agent;
wherein the device is configured to be injected into the vitreous of the patient's eye; and
wherein the device is configured to provide a substantially constant dosing rate of the pharmaceutically active agent for at least one month.
2. The method of claim 1 , wherein the pharmaceutically active agent is selected from the group consisting of anesthetics, anti-cancer agents, anti-fungal agents, anti-viral agents, cell transport/mobility impeding agents, anti-glaucoma agents, immunological response modifiers, peptides, proteins, steroidal compounds, corticosteroids, antibacterial agents, neuro-protectants, anti-inflammatory agents, anti-allergenic agents, anti-cholinesterases, miotics, and mydriatics.
3. The method of claim 1 , wherein the bioerodible outer member is tubular.
4. The method of claim 3 , wherein each end of the tubular bioerodible outer member comprises a delivery port.
5. The method of claim 1 , wherein the device is configured to provide a substantially constant dosing rate of the pharmaceutically active agent for one month to six months.
6. The method of claim 1 , wherein the device is configured to provide a substantially constant dosing rate of the pharmaceutically active agent for six months to one year.
7. The method of claim 1 , wherein the device is configured to provide a substantially constant dosing rate of the pharmaceutically active agent for one to three years.
8. The method of claim 1 , wherein the pharmaceutically active agent is a corticosteroid.
9. The method of claim 1 , wherein the device is configured to provide a substantially constant dosing rate of the pharmaceutically active agent for at least two months.
10. The method of claim 1 , wherein the device is designed to fit through a needle with a gauge of 25 or larger.
11. The method of claim 4 , wherein at least one delivery port has a polymeric cap.
12. The method of claim 4 , wherein at least one delivery port has a polyvinyl alcohol cap.
13. The method of claim 1 , wherein the polyvinyl alcohol constitutes about 1 to about 20% w/w of the drug core.
14. The method of claim 1 , wherein the drug core was manufactured using a solution of about 5 to about 15% w/w polyvinyl alcohol.
15. The method of claim 1 , wherein the drug core was heat treated during manufacturing.
16. The method of claim 1 , wherein the device was heat treated during manufacturing.
17. The method of claim 1 , wherein the eye disease or disorder is selected from the group consisting of glaucoma, proliferative vitreoretinopathy, macular edema, diabetic macular edema, age-related macular degeneration, diabetic retinopathy, uveitis, ocular neovascularization, retinal vein occlusion, geographic atrophy, and ocular infection.