Coated particles and their uses
Provided are coated particles and methods of their use for providing healthcare benefits. More specifically, the present invention provides amino acid and/or polymer-coated particles, or particles coated with other materials, for binding to, or otherwise associating with, surfaces of the oral cavity.
1. A coated micro/nano-particle comprising:
(a) a substrate consisting of microparticles or nanoparticles made from poly(lactic-co-glycolic acid) (“PLGA”) and
(b) a coating covalently bonded to the substrate comprising one or more materials selected from the group consisting of ethyl lauroyl arginate HCl,
2. The coated micro/nano-particle of claim 1 , wherein the coating comprises the Compound 17, the Compound 18 or the Compound 31.
3. The coated micro/nano-particle according to claim 1 further comprising an active ingredient.
4. A method of providing a benefit to the oral cavity comprising introducing to said oral cavity a coated-micro/nano-particle according to claim 1 .
5. A method of providing a benefit to the oral cavity comprising introducing to said oral cavity a coated micro/nano-particle according to claim 3 .
6. A method of measuring adherence of a coated micro/nano-particle according to claim 1 to a hydroxyapatite surface comprising providing saliva-coated hydroxyapatite particles (HAP) and the coated micro/nano-particles, mixing said saliva-coated HAP and the coated micro/nano-coated particles and incubating the mixture, washing the resulting HAP to remove loose coated micro/nano-particles and collecting the eluent, to determine how much coated micro/nano-particle is sticking to the saliva coated HAP and how much has eluted off.