Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods
Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable.
1. A prosthetic heart valve device for treating a native valve having a native annulus and native leaflets, the prosthetic heart valve device including a radially compressed configuration and a radially expanded configuration, the prosthetic heart valve device comprising:
a valve support expandable from a low-profile configuration for delivery to an expanded configuration for implantation at the native valve, the valve support including an inflow end and an outflow end;
a prosthetic valve mounted to the valve support and adapted to allow blood flow in a downstream direction and to block blood flow in an upstream direction; and
an anchoring member including a first end attached to the valve support at the inflow end of the valve support and a second end spaced from the valve support with the prosthetic heart valve device in the radially expanded configuration,
wherein the anchoring member includes at least a portion extending radially outward and in a downstream direction relative the first end of the anchoring member.
2. The prosthetic heart valve device of claim 1 , wherein the anchoring member includes a generally longitudinally extending integration region at the first end of the anchoring member, the integration region attached to the inflow end of the valve support, a first portion extending outwardly from the integration region, and a second portion extending generally longitudinally from a distal end of the second portion.
3. The prosthetic heart valve device of claim 2 , wherein the integration region of the anchoring member includes anchoring-member eyelets, the inflow end of the valve support includes valve-support eyelets, and wherein the prosthetic heart valve device further includes connectors attaching the anchoring member to the valve support at the anchoring-member eyelets and the valve-support eyelets.
4. The prosthetic heart valve device of claim 3 , wherein the connectors are selected from the group consisting of sutures, solder, welds, staples, rivets, mechanical interlocks, friction connectors, interference fit, or any combination thereof.
5. The prosthetic heart valve device of claim 4 , wherein the connectors comprise rivets.
6. The prosthetic heart valve device of claim 4 , wherein the connectors comprise sutures.
7. The prosthetic heart valve device of claim 2 , wherein an outer surface of the fixation portion extends generally parallel to a central longitudinal axis of the prosthetic heart valve device.
8. The prosthetic heart valve device of claim 2 , wherein the second portion is inclined inwardly from the first portion toward a central a central longitudinal axis of the prosthetic heart valve device.
9. The prosthetic heart valve device of claim 8 , wherein the second portion is inclined inwardly at an angle of 0 to 30° relative to the central longitudinal axis.
10. The prosthetic heart valve device of claim 2 , wherein the second portion is inclined outwardly from the first portion away from a central longitudinal axis of the prosthetic heart valve device.
11. The prosthetic heart valve device of claim 10 , wherein the second portion is inclined outwardly at an angle of 0 to 45° relative to the central longitudinal axis.
12. The prosthetic heart valve device of claim 2 , wherein the second portion is generally parallel to a surface of the valve support.
13. The prosthetic heart valve device of claim 1 , wherein the anchoring member comprises a plurality of rows of diamond-shaped cells.
14. The prosthetic heart valve device of claim 13 , wherein the anchoring member comprises an additional row of cells, wherein each cell of the additional row of cells is larger than each diamond-shaped cell of the plurality of rows of diamond-shaped cells.
15. The prosthetic heart valve device of claim 13 , wherein the valve support includes hexagonal shaped cells.
16. The prosthetic heart valve device of claim 13 , wherein the valve support includes a plurality of longitudinal struts and a plurality of rows of angled struts, wherein first angled struts of a first row of the plurality of rows angled struts extend from the longitudinal struts in a downstream direction, and wherein second angled struts of a second row of the plurality of rows of angled struts adjacent the first row extend from the longitudinal struts in a downstream direction.
17. The prosthetic heart valve device of claim 1 , wherein the outflow end of the valve support includes a plurality of arms extending radially outward and in an upstream direction relative the anchoring member with the prosthetic heart valve device in the radially expanded configuration, the plurality of arms being configured to extend behind the native leaflets.
18. The prosthetic heart valve device of claim 17 , wherein the arms are configured to engage tissue independently of the anchoring member.
19. The prosthetic heart valve device of claim 17 , wherein the anchoring member includes at least a portion being configured to contact an inner surface of the native leaflets.
20. The prosthetic heart valve device of claim 19 , wherein the anchoring member and valve support arms are configured to sandwich the native leaflets.