Kits and methods for induction of cardioversion in subjects with atrial arrhythmias
Disclosed herein are methods and kits for treating or preventing a heart condition, e.g., cardiac arrhythmia, e.g., atrial arrhythmia, using potassium channel inhibitors and class I antiarrhythmic agents. Also disclosed herein are methods and kits for treating a heart condition via an intravenously, orally, or inhalationally administered fixed-dose combination of a sodium channel blocker and a class I antiarrhythmic agent.
1. A pharmaceutical composition comprising flecainide or a pharmaceutically acceptable salt thereof, ibutilide or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients, diluents, or carriers.
2. The pharmaceutical composition of claim 1 , wherein said pharmaceutical composition is in a form of a liquid solution.
3. The pharmaceutical composition of claim 2 , comprising about 1 mg/mL to about 2 mg/mL flecainide or a pharmaceutically acceptable salt thereof, and about 0.01 mg/mL to about 0.1 mg/mL ibutilide or a pharmaceutically acceptable salt thereof.
4. The pharmaceutical composition of claim 2 , comprising about 2 mg/mL flecainide or a pharmaceutically acceptable salt thereof, and about 0.014 mg/mL ibutilide or a pharmaceutically acceptable salt thereof.
5. The pharmaceutical composition of claim 2 , comprising about 1 mg/mL flecainide or a pharmaceutically acceptable salt thereof, and about 0.007 mg/mL ibutilide or a pharmaceutically acceptable salt thereof.
6. The pharmaceutical composition of claim 2 , wherein a mass/mass ratio of said flecainide or pharmaceutically acceptable salt thereof to said ibutilide or said pharmaceutically acceptable salt thereof in said pharmaceutical composition is from 60:1 to 240:1.
7. The pharmaceutical composition of claim 2 , wherein a mass/mass ratio of said flecainide or pharmaceutically acceptable salt thereof to said ibutilide or said pharmaceutically acceptable salt thereof in said pharmaceutical composition is about 120:1.
8. The pharmaceutical composition of claim 7 , comprising about 1 mg/mL to about 2 mg/mL flecainide or a pharmaceutically acceptable salt thereof.
9. The pharmaceutical composition of claim 7 , comprising about 1 mg/mL flecainide or a pharmaceutically acceptable salt thereof.
10. The pharmaceutical composition of claim 1 , wherein said flecainide or a pharmaceutically acceptable salt thereof is flecainide acetate.
11. The pharmaceutical composition of claim 1 , wherein said flecainide or a pharmaceutically acceptable salt thereof is flecainide hydrochloride.
12. The pharmaceutical composition of claim 1 , wherein said ibutilide or pharmaceutically acceptable salt thereof is ibutilide hemifumarate.