BONE PUTTY FOR BONE PORE AND VOID FILLING
A bone pore or void filling composition is described. The composition includes a mixture of: a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate; a blend of polyethylene glycol polymers having different molecular weights; a bone growth stimulator; and bioactive glass. A kit for containing the bone pore or void filling composition, and methods for using the composition to fill a bone pore or void are also described.
1 . A bone pore or void filling composition, comprising a mixture of:
a collagen component comprising a type I collagen and/or a type I collagen-glycosaminoglycan coprecipitate;
a polyethylene glycol component comprising a blend of polyethylene glycol polymers having different molecular weights,
a calcium phosphate component comprising tricalcium phosphate; and
a glass component comprising bioactive glass,
wherein the tricalcium phosphate and the bioactive glass in the mixture are configured to fill bone pores of a size less than 600 microns.
2 . The composition of claim 1 , wherein the tricalcium phosphate comprises particles having a size from 50 to 300 microns.
3 . The composition of claim 1 , wherein the bioactive glass comprises particles having a size from 50 to 300 microns.
4 . The composition of claim 1 , wherein the blend of polyethylene glycol polymers consists of a first and a second polyethylene glycol polymer having different molecular weights.
5 . The composition of claim 4 , wherein the first polyethylene glycol polymer has molecular weight within the range of 1350 g/mol to 1650 g/mol and the second polyethylene glycol polymer has a molecular weight within the range of 350 g/mol to 650 g/mol.
6 . The composition of claim 1 , wherein the bone pore filling composition comprises a type I collagen.
7 . The composition of claim 1 , wherein the bone pore filling composition comprises a type I collagen-glycosaminoglycan coprecipitate
8 . The composition of claim 1 , wherein the bioactive glass comprises from 3% to 7.5% by weight.
9 . The composition of claim 1 , wherein the tricalcium phosphate comprises from 15% to 30% by weight.
10 . The composition of claim 1 , wherein the weight percent of the type I collagen or the type I collagen-glycosaminoglycan coprecipitate is from 0.2% to 1.5%.
11 . The composition of claim 1 , wherein the composition further comprises a hemostatic agent.
12 . A method of filling a bone pore or void, comprising administering a composition according to claim 1 to the site of the bone pore or void.
13 . The method of claim 12 , wherein the composition is manually applied to the bone pore or void.
14 . The method of claim 12 , wherein the composition is applied to the bone pore or void using a syringe.
15 . The method of claim 12 , wherein the bone pore has a diameter from 75 microns to 350 microns.
16 . The method of claim 12 , wherein the composition is applied to a bone pore in spongy bone.
17 . The method of claim 12 , wherein the composition is applied to a natural bone void.
18 . A bone pore or void filling kit, comprising:
the bone pore or void filling composition of claim 1 ;
a syringe for administering the composition; and
a sterile package for holding the composition and the syringe.
19 . The kit of claim 18 , further comprising instructions for filling a bone pore.
20 . The kit of claim 18 , wherein the blend of polyethylene glycol polymers consists of a first and a second polyethylene glycol polymer having different molecular weights.