IP Library Granted Patent US 11,737,699
Granted Patent B2
US 11,737,699 · App. 17/719,866 · Granted Aug 29, 2023

Systems and methods for performing electrophysiology (EP) signal processing

Inventors: Budimir S. Drakulic (Los Angeles, CA); Sina Fakhar (Encino, CA); Thomas G. Foxall (Surrey, CA); Branislav Vlajinic (Los Angeles, CA); Samuel J. Asirvatham (Rochester, MN)
Assignees: BioSig Technologies, Inc.; Mayo Foundation for Medical Education and Research
A61B5/30A61B5/0245A61B5/308A61B5/318A61B5/7203A61B5/7225A61B5/7246A61B5/0006A61B5/0215A61B5/02405A61B5/0538A61B5/352A61B5/361A61B5/363A61B5/366A61B5/4836A61B5/7217A61B5/742A61B5/7435A61B18/1492A61B2018/00351A61B2018/00577A61B2562/18A61B2562/223G16H40/63H01L2924/14335H02H9/04H02H9/045H03F3/45H03F3/45475H03F3/68H03F2200/129H03F2200/171H03F2200/234H03F2200/375H03F2200/451H03F2203/45116H03F2203/45528H03F2203/45601H03K5/125H04L43/02H04L47/50
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Quick Facts
Patent No.
US 11,737,699
App. No.
17/719,866
Granted
Aug 29, 2023
Kind
B2
Abstract

Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.

Claims (33)

1. A system for producing a clean unipolar signal, comprising:

a first circuit board configured to process a first biomedical signal; and

a plurality of second circuit boards, each configured to process a corresponding second biomedical signal,

wherein the first circuit board and the plurality of second circuit boards each comprise a corresponding set of components comprising an input protection circuit, a radio frequency filter circuit, a differential signal amplification stage, and an analog-to-digital (A/D) converter organized in a corresponding processing path, wherein each of the set of components is substantially the same and each of the processing paths is substantially the same,

wherein the first circuit board further comprises a large-signal detection circuit coupled to the differential signal amplification stage of the first circuit board and configured to remove signal saturation from the first biomedical signal being output from the differential signal amplification stage of the first circuit board based on a time constant, wherein the time constant specifies a length of time that the first biomedical signal being output from the differential signal amplification stage of the first circuit board is at a maximum amplitude, and

wherein the first circuit board processes the first biomedical signal using its corresponding processing path and each second circuit board processes its corresponding second biomedical signal using its corresponding processing path.

2. The system of claim 1 , wherein a single Wilson Central Terminal (WCT) signal is used for the first circuit board and the plurality of second circuit boards.

3. The system of claim 1 , wherein the input protection circuit of the first circuit board is configured to shunt a voltage of the first biomedical signal greater than or equal to 300 V.

4. The system of claim 1 , wherein the radio frequency filter circuit of the first circuit board is configured to attenuate an amplitude of the first biomedical signal between about 300 kHz and about 600 kHz.

5. The system of claim 1 , wherein the first circuit board further comprises a low-frequency feedback circuit coupled to the radio frequency filter circuit of the first circuit board, wherein the low-frequency feedback circuit is configured to drive a voltage of a reference node of the radio frequency filter circuit of the first circuit board to increase input impedance of signal frequencies of the first biomedical signal such that the radio frequency filter circuit of the first circuit board is configured to act as an open circuit at the signal frequencies of the first biomedical signal.

6. The system of claim 1 , wherein the first circuit board further comprises a buffer.

7. The system of claim 6 , wherein the differential signal amplification stage of the first circuit board comprises an instrumentation amplifier, a first differential amplifier, and a second differential amplifier, wherein an output of the instrumentation amplifier has a differential gain of about 20, an output of the first differential amplifier has a differential gain of about 1, and an output of the second differential amplifier has a differential gain of about 0.5.

8. The system of claim 7 , wherein the A/D converter of the first circuit board is coupled to an output of the second differential amplifier of the first circuit board, wherein the A/D converter of the first circuit board is configured to convert the first biomedical signal to a digital format.

9. A method producing a clean unipolar signal, comprising:

processing, by a first circuit board, a first biomedical signal; and

processing, by a plurality of second circuit boards, a corresponding second biomedical signal,

wherein the first circuit board and the plurality of second circuit boards each comprise a corresponding set of components comprising an input protection circuit, a radio frequency filter circuit, a differential signal amplification stage, and an analog-to-digital (A/D) converter organized in a corresponding processing path, wherein each of the set of components is substantially the same and each of the processing paths is substantially the same,

wherein the first circuit board further comprises a large-signal detection circuit,

wherein the processing, by the first circuit board, the first biomedical signal further comprises removing, by the large-signal detection circuit of the first circuit board, signal saturation from the first biomedical signal being output from the differential signal amplification stage of the first circuit board based on a time constant, wherein the time constant specifies a length of time that the first biomedical signal being output from the differential signal amplification stage of the first circuit board is at a maximum amplitude, and

wherein the first circuit board processes the first biomedical signal using its corresponding processing path and each second circuit board processes its corresponding second biomedical signal using its corresponding processing path.

10. The method of claim 9 , wherein a single Wilson Central Terminal (WCT) signal is used for the first circuit board and the plurality of second circuit boards.

11. The method of claim 9 , further comprising:

shunting, by the input protection circuit of the first circuit board, a voltage of the first biomedical signal greater than or equal to 300 V.

12. The method of claim 9 , further comprising:

attenuating, by the radio frequency filter circuit of the first circuit board, an amplitude of the first biomedical signal between about 300 kHz and about 600 kHz.

13. The method of claim 12 , further comprising:

driving, by a low-frequency feedback circuit coupled to the radio frequency filter circuit of the first circuit board, a voltage of a reference node of the radio frequency filter circuit of the first circuit board to increase input impedance of signal frequencies of the first biomedical signal such that the radio frequency filter circuit of the first circuit board is configured to act as an open circuit at the signal frequencies of the first biomedical signal.

14. The method of claim 9 , wherein the first circuit board further comprises a buffer and the differential signal amplification stage of the first circuit board comprises an instrumentation amplifier, a first differential amplifier, and a second differential amplifier, and further comprising:

outputting, by the instrumentation amplifier, a differential gain of about 20;

outputting, by the first differential amplifier, a differential gain of about 1; and

outputting, by the second differential amplifier, a differential gain of about 0.5.

15. The method of claim 14 , wherein the A/D converter of the first circuit board is coupled to an output of the second differential amplifier of the first circuit board, and further comprising:

converting, by the A/D converter of the first circuit board, the first biomedical signal to a digital format.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Apr 1, 2026
From: YA II PN, LTD
To: STREAMEX CORP.
Reel/Frame 074249/0365 →
SECURITY INTEREST Recorded Nov 5, 2025
From: STREAMEX CORP.
To: YA II PN, LTD.
Reel/Frame 072796/0591 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 13, 2022
From: DRAKULIC, BUDIMIR S.; FAKHAR, SINA; FOXALL, THOMAS G.; VLAJINIC, BRANISLAV
To: BIOSIG TECHONOLOGIES, INC.
Reel/Frame 059588/0833 →
Continuity (5)
Continuation 16582927 · Sep 25, 2019
Continuation 16543061 · Aug 16, 2019
Continuation PCTUS2019031434 · May 9, 2019
Provisional Application 62669345 · May 9, 2018
Related Publication 20220249006A1 · Aug 11, 2022