NITRIC OXIDE GENERATION, DILUTION, AND TOPICAL APPLICATION COMPOSITIONS, SYSTEMS, APPARATUS AND METHODS
An apparatus for controlled delivery of nitric oxide. A pump draws air through an activated carbon filter and into a reaction chamber. The generation of nitric oxide occurs in the reaction chamber. A second pump draws the gas in the reaction chamber through a calcium hydroxide filter and delivers the nitric oxide through an orifice, or aperture, that controls the flow of nitric oxide delivered. The nitric oxide is filtered through a calcium hydroxide filter just prior to being made available for various nitric oxide therapies. Topical applications that provide a nitric oxide therapy to a surface are also provided.
1 .- 14 . (canceled)
15 . A method for providing a topical nitric oxide therapy system, comprising:
providing a nitrite medium in a first container, the nitrite medium comprising about 95% water by weight, about 3% of a nitrite component by weight, greater than about 1% hydroxypropyl methylcellulose polymers by weight, and less than about 1% by weight of a combination of additives comprising two or more of methylchloroisothiazolinone, methylisothiazolinone, sodium hydroxide, ethylenediamine tetraacetate tetrasodium salt, and citric acid;
providing an acidic medium in a second container, the acidic medium comprising about 89% water by weight, about 9% by weight of a combination of two or more acidic reactants; greater than about 1% hydroxypropyl methylcellulose polymers by weight, and less than about 1% by weight of a combination of additives comprising two or more of methylchloroisothiazolinone, methylisothiazolinone, sodium hydroxide, and ethylenediamine tetraacetate tetrasodium salt;
combining the nitrite medium and the acidic medium to form a nitric oxide topical medium producing nitric oxide suitable for topical application and suitable for administering nitric oxide therapy; and
applying a therapeutically effective amount of the nitric oxide topical medium to a treatment surface suitable for receiving nitric oxide therapy, whereby the application of the therapeutically effective amount is adapted to deliver a dose of nitric oxide at the treatment surface of a patient.
16 . The method of claim 15 , wherein the water comprises one or more of distilled water and deionized water.
17 . The method of claim 15 , wherein the nitrite component comprises one or more nitrite reactants of sodium nitrite and potassium nitrite.
18 . The method of claim 15 , wherein the combination of the acidic reactants comprises about 3% lactic acid by weight, about 3% ascorbic acid by weight, and about 3% citric acid by weight.
19 . The method of claim 15 , wherein one or more of the first and second containers comprise a pump configured to dispense a medium by a pump action.
20 . The method of claim 15 , wherein the therapeutically effective amount of the topical medium is configured to produce nitric oxide gas having a concentration of between about 500 ppm and about 1000 ppm.
21 . The method of claim 15 , wherein the therapeutically effective amount of the topical medium is configured to produce nitric oxide gas having a concentration of between about 1000 ppm and about 2000 ppm.
22 . The method of claim 15 , wherein the treatment surface is the skin of a patient.
23 . The method of claim 15 , wherein the topical medium is repeatedly applied to an open wound once a day for at least one week.
24 . The method of claim 15 , wherein the topical medium is repeatedly applied to an open wound once a day for up to three weeks.
25 . The method of claim 15 , wherein the topical medium is repeatedly applied to an open wound for up to five weeks.
26 . The method of claim 15 , wherein the dose of nitric oxide provides an antimicrobial treatment to the patient.
27 . The method of claim 15 , wherein the dose of nitric oxide provides an antifungal treatment to the patient.
28 . The method of claim 15 , wherein the dose of nitric oxide provides an antiviral treatment to the patient.
29 . The method of claim 15 , wherein the dose of nitric oxide provides an antibacterial treatment to the patient.
30 . The method of claim 15 , wherein the dose of nitric oxide provides an antiseptic treatment to the patient.
31 . The method of claim 15 , wherein the dose of nitric oxide provides an analgesic treatment to the patient.
32 . The method of claim 15 , wherein the dose of nitric oxide provides an anti-inflammatory treatment to the patient.
33 . The method of claim 15 , wherein the dose of nitric oxide provides a biofilm-dispersion treatment to the patient.
34 . The method of claim 15 , wherein the dose of nitric oxide provides an anti-cancer treatment to the patient.