POLYKETIDE COMPOUND AND DERIVATIVES THEREOF FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER
A compound, in particular a polyketide compound and derivatives thereof, for use in prevention and/or treatment of a neurological disorder in an individual. The compound can promote lactate secretion. A composition can contain the compound, and a food or food extract can be enriched with said compound or composition.
1 . A compound of general structural formula (Ia)
wherein R1 to R9 are individually selected from H and CH3; and
R10 to R17 are individually selected from H, C═O, and OH;
or a salt thereof for use in the promotion of lactate secretion in an individual.
2 . The compound according to claim 1 , wherein the compound is a macrolide.
3 . The compound according to claim 1 , wherein the compound is further modified by one or more of:
a. Reduction of a carbonyl to a hydroxyl group
b. Dehydration
c. Double bond reduction.
4 . The compound according to claim 1 , wherein the compound is lactonised between the carboxylic acid group at position 19 and the alcoholic group at position 3, creating an 18 atom ring to form compound A:
5 . A composition comprising the compound according to claim 1 , wherein the composition is a pharmaceutical or nutraceutical composition.
6 . A method for prevention or treatment of a neurological disorder and/or improvement of memory function, the method comprising administering a compound of general structural formula (Ia)
wherein R1 to R9 are individually selected from H and CH3; and
R10 to R17 are individually selected from H, C═O, and OH;
or a salt thereof for use in the promotion of lactate secretion in an individual to an individual in need of same.